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I suspect this comment won't age well, but as always, time will tell. When it comes to Susan Shore, history is on the side of "hurry up and wait." -

The Moller Skycar approach.

Anyone remember when the descriptions of its effect said it rewired your brain and hence this would be a one shot treatment??? Pepperidge Farm remembers.

It's always an experience to go cold-turkey on Tinnitus Talk for 6+ months and then pop back in this thread. I do think when it comes to Susan Shore, the best approach is not to follow her progress so closely that you go through the emotional see-saw of ETAs slipping and slipping into the...

IMHO, your post comes across as victim-blaming.

Especially since the FDA approval takes Neuromod's word for it that it won't make tinnitus worse. Very disappointed in the FDA. I never thought we'd rubber stamp this. I'd like to believe that even if this barely works above placebo that it's been improved enough not to worsen your tinnitus but...

These announcements remind me of the cavalcade of battery tech breakthroughs. There is a huge gap between lab results and the real world, unfortunately.

This. Given enough time someone usually chimes in on this thread to try to defend or root for Lenire a little bit but it doesn't change the underlying (at best) wishy washy testimonials. The only device worth tracking of this sort is Susan Shore's and even there I'm not sure the testimonials...

I can't imagine Gates, Bezos, and Musk in the same room together. The three are arch enemies.

Only took almost 5 years.

The dreaded "disimprovement" ala Lenire? I certainly hope not.

Yep. It's mostly an attempt to put a positive spin on results that are, at best, mild.

I'd like to believe something could come from this but a lot of Musk's projects are driven more by arrogance than the scientific principles he says he stands for, with the usual failed results. The one true achievement I'd credit to Musk is the Falcon 9 rocket and that's about it. Throwing the...

Yep, like the seemingly superior device THEY ALREADY HAD which they abandoned.

Tell me about it. There is no justice in this world.

15 dB is still classified as no relief? This report of permanent alteration is why it's so maddening the mixed messaging on whether neuromodulation lasts or requires lifetime treatments.

That's one good way to avoid disappointment. I bet you'll get what you hope to get.

When I read "magical thinking" articles all I can think of is this. (the first prediction is sadly topical)... The second, actually came to pass.

Which is the path of the tinnitus sufferer.

Anytime the results are inconsistent from what's been claimed earlier, it raises red-flags.

Meaning the improvements wear off?

But given the well-established intractability of tinnitus how likely is it that those outside the acceptance criteria will benefit? I mean, we already have studies suggesting it will work (i.e. Neuromod's) which turn out to not even be trustworthy. Is it reasonable to leave a huge percentage...

There's no proof that standing on your head might not cure cancer yet, so why not try it? Point being that the prove-a-negative approach is a backwards one. Those evaluating treatments want evidence that it will work for them, not go on a wing and a prayer.

They must belong to the Susan Shore school of R&D timelines.

I'm sure this will generate a ton of discussion but this is the table I am most interested in: https://www.nature.com/articles/s41598-022-13875-x/tables/3 Around a quarter to a third of trial participants report worsening within the first half of the treatment. This then somehow drops to 5-10%...

What a surprise.

I mean this with all due sympathy but this is the very sort of thing that questions the legitimacy of Lenire as a treatment. What I see here is no clear cause and effect and a see-saw that could very well be driven by rather than mediated by the use of Lenire. Eliminating variables seems to be...

I'll take that seriously when it's accompanied by the entrance of a trial participant into a Tinnitus Talk discussion or interview with Tinnitus Talk staffers.

After the seemingly credible trial data from Neuromod turned out to be BS I'm not sure any trial data can be trusted. I want to hear from real people some unequivocal stories that the loudness of their tinnitus has gone down, not that they subjectively "feel better" or they are "managing better".

As far as my own level of hope on neuromodulation, I feel the burden of proof is to show that ANY of them work in a meaningful way (including Shore's). I got excited about this on the basis of only a couple testimonials from Tinnitus Talk members. The fact one of them was treated (and claimed...

And as we've learned from Lenire, even that is dubious.

LOL. Another treatment I know, but when reading this I suddenly have images of Susan Shore's head in a Futurama glass jar.

This thread needs a healthy dose of...

I agree with that. Not to engage in FUD, but the regulatory agencies are really naive about the harm this class of device could potentially do. I would hope the FDA is more on the ball than Europe where this is concerned.

Given Susan Shore's age, she might think of picking up the pace or at least finding an heir apparent.

Or IF. The story of so many treatments in development resemble this: I'm not happy about Lenire either, but at least it entered the market.

Sure, damage can be immediate, but are people with already damaged hearing, presumably cautious about their ears, let's say, rushing out to the gun-range right after taking FX-322?

The term was used by those pioneering it, though, which understandably hurt credibility.

I apologize for not reading the entire thread but I can't help but feel a sense of dejavu with the South Korean plasma injection therapy that one prominent member was evangelizing for a while. There seems to be a cottage industry of treatments available in South Korea due to what looks like a...

We will watch your research with much anticipation.

IMHO, I think maybe the time has come for Tinnitus Talk to conduct a follow-up interview with Neuromod and be a bit bolder in confronting them with the disconnect between the results gathered here and their marketing spin/hype. I don't think much would be lost if bridges are burned over it.

I'm avoiding MRIs if at all possible so that's a nope for me.

I work in Boston and could easily participate but I am wondering what benefit this research will make... If it were an actual treatment then it would be worth it to me.

Similar for me. There is a biochemical thing involved in sleep that mediates tinnitus which I wish could be bottled and sold.

I remember similar sentiments about team-Neuromod vs. team-Shore prior to Lenire's release with many jumping on the Neuromod bandwagon based on them seeming to move at lightspeed vs. Shore's snail's pace and we saw how that one turned out. I understand the emotions involved in but just...

Yeah, kind of like fusion where no matter what year it is, it's always going to roll out 20 years in the future.

Tell that to Lenire "disimprovers", assuming they are still alive.

I've come to expect regular attempts to tone-police from Tinnitus Talk threads such as this. Critical posts are always followed by tone-policers and the cycle just swirls around endlessly.

Seems like FREQ is spending more time on marketing than R&D these days.

The sad thing is the most encouraging personal anecdotes shared here related to this kind of treatment originate from the University of Minnesota device, a research project which has since wound down. While I think this kind of treatment has potential, effectiveness seems to be wholly dependent...

That MIT article about hearing regeneration is circulating around on Google news in one shape or form or another almost like the algorithm has been gamed into viral status.

So I assume when it shifts to 2024 you will be the first to tell us all to stop being upset once again? Maybe an annual ritual?

(deep cut here) She kind of reminds me of Jimmy Page's constant teasing of new solo projects (which has gone on for over 20 years now).

A lot of it seems to be driven by the anxieties of those with a vested stock position in the company.

The real question is why is Susan Shore the only one making overly-qualifying statements about the efficacy of her treatment if most tinnitus sufferers qualify anyway? That is what is causing people to question whether this treatment will work for them, not us being "dumb".

There was also a member by the name of @Clare B.