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Hello fellow tinnitus sufferers, patients and clinicians, I wanted to reach out because I have been AWOL so to speak and I used to be very active on this very lovely forum. I had noticed in my facebook feed the story of Mr. Jones' passing. I decided that I'd log in and see the thread for...

@harleyquinn First of all, your English is very good and you shouldn't apologize for it. Hell, it's probably better written English than my own and English is my first language! :) Second, I have the high pitched sounds and the low rumbling in silence that you describe. I'm not sure what it's...

You can't just do debug.print on tinnitus, sorry lol

I don't think it's a good idea to gleam too much information from really early data. As you have said, he may be getting placebo. It may also take a good deal of time for the active drug to reach high enough concentrations in the blood to have an effect. There are a lot of factors. None of us...

I think you're in a really good position if you have tinnitus that is only intermittent. Mine never goes away no matter what I do. I think you're waaaaaay over thinking things. There is no way that stuff as low as 30 db or 40 db can harm your hearing in any way. Those are incredibly soft...

I don't think using decongestants for a little bit will make your tinnitus permanently worse. If it has any effect at all, it will be clearing up your sinuses a bit so that your ears can pop and drain. I'd be more concerned about that than what taking a decongestant for a little bit will do to...

Never say never. If you say "X will never do Y." In 99% of cases, you're setting yourself up for failure. But as @preslys said, let's stay on topic and discuss Autifony here.

God, I hate this ad. I don't know what it has to do with taxes, or anything. For 90% of us, seeing a doctor (these days still at least) early on in tinnitus is a fruitless endeavor. This has been coming up on tons of my youtube videos I watch.

Quater 3 or Quarter 4 of this year would be my guess. This trial isn't supposed to last that long, and they'll need a little time to do data analysis.

@carlos28 Welcome to our forum. Sorry to hear that you're experiencing tinnitus. It's very difficult to know for sure if it will be permanent or not. It is not uncommon for tinnitus to fade over the course of a couple of weeks. That being said, I acquired tinnitus when I was 17, and it has not...

@2131e Have you had any success initiating the enrollment onto the trial? Also, how's your wombat doing?

I agree! Their interest in this is very encouraging to say the least. Thank you all for the work on submitting what we have so far to the TRI.

I'm sorry if you had a poor experience using the drug, but no one asked you to do this. Everyone has volunteered to do this, and gone to great lengths to discuss using this drug off label with their doctors.

From experience and talking to others, how "loud" your tinnitus is really only matters in the beginning as that will influence how often you're thinking about it. However, there are people with relatively mild tinnitus who concentrate on it constantly. The loudness of tinnitus does not mean you...

I completed college after I had tinnitus. It had no effect on me being able to complete engineering school. If you stay busy with school and don't concentrate on it (easier said than done) you should be just fine! Welcome to our site. Don't saddle yourself with questions like "Now that I have...

@2131e Take that Wombat of yours and see if you can get on the trial then. I think you qualify as long as you are a resident there? I'm not sure though.

Still, the fact that we're sitting here in 2015 talking about drugs which actually have a tangible effect on tinnitus is huge. Back in the day it was "We think maybe lidocaine does? But no one gives a shit because it's a dangerous drug."

Awesome! I hope nothing but the best for you. From the Phase I trial, it sounds like the side effects were pretty mild, so hopefully it will be an easy process. Please update us when you can as we will all be looking forward to hearing about it!

My psychiatrist back in October was supposed to set up an appointment with for me with a Nuerologist (apparently there was a lot of paperwork for the referral to happen between the two) but she never got back to me about their progress. I'm meeting with her on Monday and I'm planning on asking...

Yes, I do. I take clonazepam, a benzodiazepine like Valium. I also take lexapro.

@Larry OT Sounds pretty standard to me actually. I'm on different but equivalent medication myself. Don't feel bad about it. Anxiety and depression are a total pain in the ass, and are unfortunately very common co-morbidities for a tinnitus sufferer. It sounds like your doc is really trying...

@Ilija , I wake up most mornings with the need to pop my ears and a feeling of weird pressure in there too. I think it's due to the fact that you spend most of the night not moving your mouth much, so your ears don't have a chance to change pressure or equalize. The pressure in our environments...

So you're experiencing a definite improvement then? Thanks for taking the time to update us, bud.

@Michael Murray Hey! Welcome to our forum. It sounds like you've been dealing with tinnitus for quite a long time. It also sounds like the usual suspects (ear infections, noise exposure in the military) are probably to blame for your experiences. I've had tinnitus now for over 10 years myself...

Not a problem! I'm actually kind of glad that he's willing to share his experiences with people and I am interested to hear how this all goes for him. Does anyone know if he has accompanying tinnitus with his hearing loss?

This is very exciting and I'm happy that this man is willing to reach out to others with hearing loss. However, in the interest of protecting this man's privacy, let's not put his email address up on a public forum. If he is OK with it and likes to share his experiences, he can post his email or...

In my opinion (and it's just that), you can take a little bit of cold medicine which *may* affect tinnitus if your cold is really bad. What I usually do is reserve it for if my cold is really bad. Then, I try to stick to just decongestants as they aren't so bad on your auditory system. With that...

I am patiently awaiting any updates on this! I am very excited about it!

Many people who have hearing loss and tinnitus feel that by addressing the hearing loss with hearing aids greatly helps in lessening the annoyance and perception of tinnitus. I know that everyone is different, but from the people I've known who have hearing aids, their tinnitus becomes much less...

Life happens. Tinnitus is a result of injury to your auditory system in some way. You can't blame yourself forever and be angry about it. I know that this is all to easier said than done, but it is the truth. If you accidentally injured yourself fixing a car, through carelessness or ignorance...

Hello @thesaint Welcome to TinnitusTalk. I'm glad you've found your way to this place, as it is a great community. I'm sorry to hear about your tinnitus coming back. Tinnitus can be a difficult nut to crack in terms of nailing down what causes it. It sounds like you've had some definite noise...

Truth. Intellectual property theft is common in academia and especially common in industry. If you have a novel mode of treatment, it is to your benefit to hoard that knowledge and be the first to discover.

I would be very surprised if the birth control took 5 years to cause your tinnitus. If it was the cause I imagine it would have happened a lot sooner than that. Have you had any sickness, major stress events or noise traumas recently?

I can give you my quick one-off summary: In 2014, more late stage clinical trials for tinnitus treatments were either in operation or being prepared to start than ever before. There are clinical trials for multiple modes of treatment, from vagus nerve stimulation, to intratympanic injection of...

Feel free to hit me up for money or time if it is needed.

@Christian78 so it sounds like you're winding down your personal experiment with trobalt. I've always had a little bit of a difficult time extracting exactly what you mean from your posts. Has your tinnitus improved with trobalt? Has it returned to the original baseline as you've discontinued...

I don't think it's "safe to say" that AUT00063 will work if Retigabine does. Just because it's in the same class of drugs does not mean it's identical in any way. There are a whole host of factors that go into making a medication successful. I think it's promising, but ATEOS has a very good...

And this right here, ladies and gentlemen, demonstrates the power of this collective community. Thank you for your efforts and contribution ATEOS, and everyone involved.

Is Autifony listed on any stock exchanges? I don't think it's a publicly offered company yet. Auris Medical and GenVec are, however.

You presented this to the ATA already? Thanks

Potassium channels do control heart function. However, the potassium channels that retigabine works on are not supposed to be the same ones that control heart function. It is unfortunate that you've had this side effect.

Well, the good thing about this trial is that it's slated to be completed by June of 2015. We'll probably get results a few months after that. If they start ramping up for a phase IIb trial right before the end of the trial or immediately after, that will be a good indictation that preliminary...

@mcgregor does that mean you're participating in the trial in the UK then?

@T-Bach Your contribution to the forum is greatly appreciated. I did not know that Otonomy is going to be starting a trial in the near future. Thank you for the information. It seems like you know a good deal about them. We encourage debate here at TT, but we will not tolerate aggressive...

They decided to try and save money by requiring that participants in the UK Tinnitus trial have some sort of measurable hearing loss. If they can show that hearing is improved as well, they might get more funding. Kind of like killing two birds with one stone. If they were concerned that they...

Those brits are always ruining a good time I tell you! :) Only kidding of course, I wish the best for all those involved in this study.

Can we get some more updates from you all? I'm going to be having my appointment with the neurologist soon, and I'd like to go in with some ammunition, as far as user experiences go.

@Marius T , Please don't use my opinions as your only source for information. Proper consultation of the risks vs. the benefits with a professional is always the best route. However, if you could find the people running the trial, they will be able to give you a lot better information about...

It's a shame that your ENT could care less about clinical trials that are taking place to treat tinnitus. I suppose that is just a reflection of the old attitude that "nothing can be done about tinnitus, and will ever be". However, I think people are seriously blowing the possibility of side...

Was Craig a member here on TT? I'm so sorry to hear about the loss of your friend. My heart breaks at the loss of anyone because of damned tinnitus.

I highly doubt that AUT00063 will be a cure. A cure implies that if you take it for a certain amount of time, your tinnitus is gone. I would bet my next paycheck that if AUT00063 is approved, you will have to take it for the rest of your life, and it most likely will diminish or greatly diminish...

Thank you gentlemen. I must have missed that. I'm so used to checking the clinicaltrials.gov site of the US that I didn't even think about checking the NHS site for the UK. Pity they have that hearing loss requirement. I'm wondering if they are trying to see in the same stroke if AUT00063 has an...

Can anyone link me to some specific proof regarding this hearing loss requirement for eligibility in the autifony phase IIA trial? It certainly is not listed on their website. Regarding their QUIET-1 study, the Autifony site specifically says that people who have had tinnitus for at least six...

No, as far as we know you don't have to have a measurable hearing loss. I don't think it's a disqualifying factor either. You just have to have medically documented tinnitus. What that means is that they will want records from whatever medical provider you have seen (ENT, GP, Audiologist) who...

@Zimichael Maybe I didn't catch it in there. How's your tinnitus today? Is it doing better?

It depends. Were you taking the anti-depressant before you started having tinnitus? If your AD therapy is due to a condition unrelated to your tinnitus, they will allow you to be on the trial. If you are taking the AD because of anxiety/depression induced by the tinnitus... well they won't like...

No, most don't... lol. Although I must admit 58 pages is a bit intimidating. @Johno Thanks for updating your progress form today. I was especially glad to hear your hissing tinnitus has gone down considerably. That's what my tinnitus is like... a hissing sound. Hopefully similar improvements...

I agree with @Zechariah . If you want to do a clinical trial now, I would start with the AM-101 trial. You're a perfect candidate. Autifony's compound AUT00063 is meant for more chronic cases, which you don't have for certain yet. If AM-101 doesn't work out, then you can always try Autifony...

Hey, I thought I would stop in to remind everyone to stay on track with this thread regarding the Retigabine. I know we're all excited about Autifony, but I think there's a lot that can be learned from Retigabine here and the user experiences. I'm SUPPOSED to be getting a call from the...

@Rhea, I figured I'd pop in to clear up the air on why most likely Autifony has a narrowed scope for their clinical trial. The window of time that they make available to people who have had tinnitus, greater than six months but less than eighteen speaks volumes IMO. First of all, they want...