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Can you send us a link about Chen's research?

It DOES make me feel better! You totally read my mind and understood what my concern was! :):):)

I've got a question. To the best of my knowledge, there are four main components in our auditory pathway that carry the sound to our brain. They basically are: 1) outer hair cells; 2) inner hair cells; 3) ribbon synapses; 4) spiral ganglion neurons (that is auditory nerve endings). We know...

Does it mean they would have to go through clinical trials all over again?!?

When do you expect Decibel Therapeutics will start phase I trials? Next year?

And how long will it take to bring the treatment here into the European Union, in your estimation?

I don't know what to think… the author of the article seems to know his stuff…

Yeah, according to this data it takes about 230 days to approve a fast-track designated drug. THAT'S SHOCKING. It means we may get the FX-322 injections by the end of THIS YEAR!!! :woot::love:

Do you think PIPE-505 and OTO-413 will receive fast-track designation by the FDA?

What regenerative drug is addressing nerve fiber degradation?

What are the chances of PIPE-505 and OTO-413 receiving fast-track designation, in your estimation?

Are these synapses the same elements which are said to regrow along with the new hair cells once the regeneration process is triggered by the FX-322 drug? It is believed that the auditory nerve detects the new hair cells and autonomously connects to them (through synapses, I guess) as a result...

What if the problem is in your auditory nerve?

I can't believe how excruciatingly slow the approval process is!!!

They are almost identical!!! So the laser did have a positive effect on your hearing loss and tinnitus but only in the early going?

I'm sorry, I can't find them!

And there's also this on the horizon: https://www.cuimc.columbia.edu/news/3d-printed-microneedles-open-ears-new-treatments

Is Dr. Chen's treatment administered via oral or intratympanic route?

Well, this would explain why some participants at FX-322 phase 1/2 trial had their speech-in-noise parameters improved after the injection!

What ototoxic drug did you have to take?

The audiogram isn't mine. That guy used Dr. Wilden's device (30mW per ear, 650nm)!

So... have you had other audiograms to confirm the improvements, in the meanwhile?

A few years have passed... did your audiogram show any improvements? Would you please post it?

So... what about that audiogram? Will you post it, please?

Yes... here is an example:

Umh... I disagree. Some audiograms I've seen indicate that LLLT is capable of reversing the cochlear damage even when it's acquired through the years...

Why do you think LLLT only works in the acute phase of tinnitus? Why would it be ineffective for chronic sufferers?

A combination of FX-322 and Regain's gamma-secretase inhibitor might do the trick!

That's good to hear! I'm going to take it along with Pterostilbene + Resveratrol, as David Sinclair suggests.

I guess your hearing loss is in the higher frequencies, hence the whistle only when you listen to high-pitched noises... some people here claim they have seen improvements in the high frequency spectrum thanks to a supplement called Nicotinamide Riboside, you should check it out!

So, have you had an audiogram to confirm your improvements?

Thank you! So would you recommend LLLT? What laser did you use?

Etiologies... in my case, I'm pretty sure tinnitus was caused by years of taking a non-steroidal anti-inflammatory drug for my headaches. It must have damaged my hair cells! Now I'm desperate :cry:

If tinnitus is in the brain, why does it get louder when I put my ear on the pillow, as it's a contact thing?? I'm sure I'm not the only one who experiences this while resting!

I've just found out Hansi Cross died of cancer. :cry: Does anybody know if it was brain cancer? I think it's extremely important that we make sure laser therapy is safe and unrelated to cancer!

I don't really trust second-hand stories... do you??

Is Rinri's drug even in pre-clinical phase??

The DL-form is over the counter.

Astaxanthin does cross the blood-brain barrier! Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117702/

Instead of vainly debating, we'd better try out a bottle of L-Methionine and see what happens to our ears... it's a safe drug, after all!

I know it sounds naive, but what keeps us from buying L-Methionine over the counter and just see if it works?

So...has it improved your condition to any extent?

Matrine, derived from the herb Radix Sophorae Flavescent and marketed as "Ku Shen"; Astaxanthin. https://www.tinnitustalk.com/threads/neurotrophin-3-regenerates-cochlear-synapses.31752/

Then you might be interested in some supplements which can increase the concentration of BDNF and NT-3 in your bloodstream...

We all know that the main symptom of synaptopathy is losing the ability to hear clearly when there is a noisy background... According to the results of the Phase 1/2 study, it seems that FX-322 improves speech-in-noise understanding so I guess it regrows both hair cells and their synapses, to...

Can I ask you what laser did you use? Some people claim that after LLLT their audiograms have improved... so it's possible that the treatment doesn't give relief from tinnitus but improves hearing nonetheless.

Do you guys think low-level laser therapy (for example, Dr. Wilden's) could help in this kind of situation?

What do you feel when you listen to music? How long have you been feeling this way?

That's such a long way to go... We'd better cross our fingers and hope the FX-322 treatment works as it is :(

Do you mean the microneedle that's being developed at Columbia University? BTW, does anybody know when they're going to test it in a clinical trial? Is there a schedule?

The thing is I'd like to get the injections in a 3/4 years' time at the very least, whereas you're talking about innovations that might occur in the looong run... :cry:

How could they improve?

What about performing a Phase II study in the European Union? Are you willing to conduct clinical trials in Europe, too?

Take a look at this: https://www.nature.com/articles/s41420-019-0195-1

Take a look at this: https://www.nature.com/articles/s41420-019-0195-1

Is faking a -30 dB audiogram so difficult?

Maybe you could try to get in the ongoing OTO-413 trial... have you got hidden hearing loss?

I don't think he was a member here, nevertheless he was widely known thanks to his blog: http://www.progressrec.com/curing-tinnitus.html

If they did clinical trials in Europe, would they be obliged to go through phase I again?

A strong supporter of Dr. Wilden's low-level laser therapy. Ever heard of it?