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I wasn't sure whether to start a new thread or add to this one, as my experience relates to two specific points: At least twice a week, I actually hear my tinnitus during my dreams. It's "wonderful" (ironically) to realize that even in sleep, tinnitus can still bother me. In these dreams, I...

Although I am French, I am committed to keeping Tinnitus Talk in English for the benefit of everyone. However, I wanted to share information specifically for French speakers: Höra, an app that offers a sound level meter and a speech-in-noise test. This app is supported by the French Foundation...

See my ancient post. To be more precise: I had been taking 8 drops of Clonazepam for over a year, following the advice of my oto-neurologist, without any noticeable effect. So, with my oto-neurologist’s approval, I decided to gradually increase the dosage. At 21 drops, I began to experience...

We all agree that finding a cure is essential. The title of this thread could be improved. I might have titled it something like: “Comprehensive Publications to Explore Brain Systems (including the oto-neurologic system) for Understanding the Pathophysiology of Tinnitus.” This title would...

Finally, some researchers revisited this fundamental question and conducted this experiment. Unfortunately, the results indicate that tinnitus may be even more complex than we previously thought: https://www.researchsquare.com/article/rs-5014033/v1

Sorry for my late reply. Just take a look at my investigation: https://www.tinnitustalk.com/threads/caroverine-and-inner-ear-diseases.1352/

Yet another suspicious hint of the Caroverine mystery: https://journals.lww.com/jfmpc/fulltext/2024/13100/effect_of_oral_caroverine_in_the_treatment_of.80.aspx

Hello everyone, I wanted to make a small contribution by (re)highlighting some exciting information. Unfortunately, there’s no English translation provided by the researchers for the link below, so you may need to use a translation tool: World Premiere: The Brain Revealed Like Never Before...

I'm not sure where to share this publication, but I believe it's worth reading (sorry, only the abstract is available) since it studies over 3 million workers. Perhaps the full article will provide information about tinnitus prevalence, as I received it through a research alert with the keyword...

I'm sorry, but I just came across this publication, so I do not have any further information. Feel free to contact them.

It is a pity the article is behind a paywall. Compared to this thread, similar parameters are acute tinnitus, the hypothesis of neuroinflammation, and rodents. Dissimilar parameters are noise-induced tinnitus instead of salicylate-induced tinnitus and Rolipram (an old drug) instead of TNF. →...

→ The Current State of Tinnitus Diagnosis and Treatment: a Multidisciplinary Expert Perspective

→ Efficacy and safety of SENS-401 in sudden sensorineural hearing loss: The AUDIBLE-S randomized placebo-controlled phase IIb trial

Effectiveness of transcutaneous vagus nerve stimulation for the treatment of tinnitus: an interventional prospective controlled study

FYI: I tried Gabapentin (prescribed by my psychiatrist), 2 pills of 100 mg in the evening for 3 months (July, August and September). No effect on tinnitus, no side effects either.

FYI: I took Tegretol 200 mg in the evenings for 3 months (January, February and March 2022). It was prescribed by my psychiatrist. No effect on my tinnitus. No side effects.

"Ablation of Tbx2 in postnatal, largely differentiated IHCs makes them transdifferentiate directly into OHCs, replacing IHC features with those of mature and not embryonic OHCs." I don't get it. Can someone explain to me? Do we keep this TBX2 in our body (postnatal)? Because nothing happens...

I remain skeptical: gene-editing seems to me like the Pandora Box (cancer triggering...)

This news gives me an amusing thought: the possibility, in turn, of virtually torturing my tinnitus avatar, just to get revenge, as a kind of stress relief. But the worst is that it would be able, given the principle of this virtual reality, to shout in the headphones in return and to hurt my...

Hi, sorry for the delay. Looking at my old blood tests (back to 2013/2014), my maximum dosage was 3,040 mUI/L (according to the tests, limits are 0,270 min and 4,200 max).

I will let you judge by yourself: http://www.hebertlab.ca/en/publications/

Same here after exercise. Coffee has no effect.

Systematic Review on Intra- and Extracochlear Electrical Stimulation for Tinnitus I decided not to create a new thread but to relay this publication under this thread, even if the "electrical stimulation" domain is quite big. My humble opinion is: Paradoxically, it will be easier to evaluate...

I got the answer of my first question: how did they manage to collect inner ear tissue? "To evaluate the expression of SARS-CoV-2 receptors in the human inner ear, fresh inner ear tissue was collected during surgical labyrinthectomies and translabyrinthine resections of vestibular schwannomas...

Prevalence of sleep impairment in patients with tinnitus: a systematic review and single-arm meta-analysis

Another publication from Dirk De Ridder's team: Is the posterior cingulate cortex an on-off switch for tinnitus?: A comparison between hearing loss subjects with and without tinnitus

Genetic predisposition to tinnitus in the UK Biobank population We identified 17 suggestive single nucleotide polymorphisms (p < 1e−5) spanning 13 genes in two sex-separated cohorts reporting chronic, bothersome tinnitus (control males n = 7,315, tinnitus males n = 226, control females...

Genome-wide association study identifies new loci associated with noise-induced tinnitus in Chinese populations Genotyping of 711 noise-exposed male workers of Chinese Ancestry.

@Pete88: to get a biomarker of tinnitus + to predict if a particular treatment will benefit a particular tinnitus patient (before spending money to apply it to the tinnitus patient).

Well I don't get how KCNQ1 can be at the same time a gene and an ion channel. Association Analysis of Candidate Gene Polymorphisms and Tinnitus in Young Musicians

I am little bit surprised this link has not been shared yet since Tinnitus Hub/Tinnitus Talk had heavy involvement in this study. Somatosensory Tinnitus Diagnosis - Diagnostic Value of Existing Criteria

Generalizable Sample-Efficient Siamese Autoencoder for Tinnitus Diagnosis in Listeners With Subjective Tinnitus Electroencephalogram (EEG)-based neurofeedback has been widely studied for tinnitus therapy in recent years. Most existing research relies on experts’ cognitive prediction, and...

Hidden or subclinical cochleopathy in idiopathic subjective tinnitus: extended high frequency audiometry and otoacoustic emission This affection (tinnitus) manifested as elevated EHF audiometry thresholds at 9000, 10,000, 11,200, 14,000 and 16,000 Hz. Most tinnitus patients had pitch matching...

Efficacy of tinnitus retraining therapy in the treatment of tinnitus: A meta-analysis and systematic review

Efficacy of Repetitive Transcranial Magnetic Stimulation (rTMS) for Tinnitus: A Retrospective Study An umpteenth retrospective study about rTMS with a more or less positive conclusion. But this time, some relevant information has been provided: "Repetitive transcranial magnetic stimulation...

I found this publication today using the UK Biobank about tinnitus: Understanding Factors That Cause Tinnitus: A Mendelian Randomization Study in the UK Biobank

For those who are interested/concerned, attached is an article titled: "Inner Ear Disorders in SCUBA Divers: A Review"

Maybe further information about Tzounopoulos research / drug description: The Neuroscience and the Treatment of Tinnitus "We place a special emphasis on mechanism-driven drug development informed by basic research findings.1 Several compounds are under clinical or preclinical investigation for...

Cause of tinnitus is not mentioned though. The Effects of Diet and Physical Activity Induced Weight Loss on the Severity of Tinnitus and Quality of Life: A Randomized Controlled Trial

Hearing loss statistics and forecasts: Hearing loss prevalence and years lived with disability, 1990-2019

It looks like the best dose is 40 µg. However, one person acquired tinnitus at this dose. Study ended at day 600 but published tests were done at week 52 (no published tests at day 600). Still no report from Novartis itself...

Clinical and scientific innovations in auditory brainstem implants For tinnitus sufferers concerned by retrocochlear deafness: "The ABI is also being investigated as a treatment option for other conditions such as intractable tinnitus".

Noises of War and Hearing Care So according to the reference of this publication, tinnitus is still the number one compensated disability: "For veterans returning from World War II (1941-1946), the Korean War (1950-1955), the Vietnam War (1961-1975), the Gulf War (1990 to present), the...

The Impact of the COVID-19 Pandemic on Tinnitus What I found interesting is that idea: "further research should be done to determine if it can be directly attributed to the virus or to other factors such as the impact of receiving critical care, ototoxic medications, and/ or the stress of...

I dropped out of this conversation a bit but understood that some were wondering what the role of VPA in the formulation of FX-322 was. By reflex, I did a very quick search on the net with the keywords "valproic acid" and "tinnitus", and I found this link: Valproic Acid-induced Hearing Loss and...

Well, Study start date: January 2011 Actual study completion date: January 2012 Only Novartis as contact (no indication of researchers like Mr. Langguth) + weird reply from Novartis to me 7 years ago. And then only "2 weeks after treatment" (overall duration of the follow up?)

Two hundred and forty-eight cases of visual snow: A review of potential inciting events and contributing comorbidities https://journals.sagepub.com/doi/abs/10.1177/0333102421996355

Sudden Brief Unilateral Tapering Tinnitus: Prevalence and Properties https://www.researchgate.net/publication/51693181_Sudden_Brief_Unilateral_Tapering_Tinnitus_Prevalence_and_Properties

I don't think this has been already posted. It's an updated review. Below is the abstract (I can't get the full text). Development of Ebselen for the Treatment of Sensorineural Hearing Loss and Tinnitus Highlights Ebselen is the first investigational new drug to advance to Phase 3 in...

Three-dimensional exoscope-assisted laser stapedotomy: a preliminary experience Purpose Stapes surgery, despite the introduction of lasers and endoscopes, still represents a challenging procedure. Recently introduced 3-dimensional exoscopes have known advantages in otological surgery. This...

I posted this publication here as it provides information to defining hyperacusis. COMPARISON OF LOUDNESS AND PAIN HYPERACUSIS Purpose Hyperacusis is a complex and poorly understood auditory disorder characterized by decreased tolerance to sound at levels that would not trouble most...

Useful Hearing Preservation Is Improved in Vestibular Schwannoma Patients Who Undergo Stereotactic Radiosurgery Before Further Hearing Deterioration Ensures Introduction The present study evaluates whether hearing deterioration during observation reduces serviceable hearing preservation rates...

Evaluation and comparison of the efficacy of long-acting betamethasone and dexamethasone as injections in the treatment of idiopathic sudden hearing loss Introduction & objective The aim of the present study was to determine the efficacy of long-acting betamethasone, and its comparison with...

Tinnitus and its associations with general health, mental health and hearing loss in a population study Abstract Background A deeper knowledge of tinnitus is essential in order to better manage and treat tinnitus and its effects. Most studies to date are based on small samples and/or conducted...

From the same team, investigation is enhanced via probes placed in the auditory canal. Tinnitus and auditory cortex; Using adapted functional near‐infrared‐spectroscopy to expand brain imaging in humans Objectives Phantom sound perception (tinnitus) may arise from altered brain activity within...

Much more information in the full article: see attached file. Prevalence of tinnitus in a sample of 43,064 children in Warsaw, Poland Objective: Tinnitus affects both adults and children. Children rarely complain spontaneously of tinnitus, and their parents are not aware of the condition. The...

Well, it is a shame that hyperacusis sufferers were not allowed to take part in this survey. A Delphi survey to determine a definition and description of hyperacusis by clinician consensus Objective There is currently no singularly accepted definition of hyperacusis. The aim of this study was...

Interesting article for those with ISSNHL, even if effect on tinnitus is not mentioned. Comparison among Three Different Steroid Therapies for Idiopathic Sudden Sensorineural Hearing Loss Background and Objectives The optimal dose or type of systemic steroid for treating idiopathic sudden...

A Three-arm, Single-blind, Randomized Controlled Trial Examining the Effects of Notched Music Therapy, Conventional Music Therapy, and Counseling on Tinnitus Objective: To compare the efficacy of three common interventions for tinnitus patients: notched music therapy, conventional music...

Cochlear implant and tinnitus–a meta-analysis Abstract Introduction Tinnitus is a frequent symptom in cochlear implant patients, often reported as persistent and disabling in implant candidates. Tinnitus is rarely considered in the preoperative evaluation of patients who are eligible for...