Genetic Predisposition for Tinnitus with rs1800795 Gene

[lymebite]

Interesting new research study finds a genetic predisposition for tinnitus among people exposed to occupational noise:

http://www.noiseandhealth.org/artic...me=17;issue=79;spage=406;epage=410;aulast=Doi

If you have had your DNA sequenced with 23andme or another provider, you can look up and see which which variation of the gene analyzed in this study you carry. The gene in question is:

rs1800795

I have genotype GG. For those who have had their DNA sequenced, would be interesting to hear which genotype others have.

 

[Briann]

I have GC. This table provides a good summary:

It seems strange to me that 25% (44/177) of those with the C allele but without a history of noise exposure have tinnitus while only 7% (2/29)of those with the C allele and with a history of noise exposure have tinnitus. I would expect noise exposure to increase the odds of tinnitus. Taken at face value, those with the C allele should expose themselves to more noise. Looks like they need a larger sample size.

 

[Markku]

I have CG.

 

[Aussie Lea]

How much does it cost to get this tested? Worth it?

 

[lymebite]

The price can vary by country and which company you use. I live in the United States and did it with 23andme. It cost US$99. I find the results interesting but so far not life-changing in any way.

 

[Frédéric]

Genetic Susceptibility to Hearing Loss from Noise Exposure
White, Patricia M. PhD

Source: https://journals.lww.com/thehearing...ceptibility_to_Hearing_Loss_from_Noise.3.aspx

From this article:
"No known gene variant is associated with tinnitus in humans or animals."

It seems it is a step back.

 

[Frédéric]

Single nucleotide polymorphisms in tinnitus patients exhibiting severe distress

Abstract
The association between distress caused by tinnitus and psychological factors such as depression and anxiety has been examined and reported. However, prognostic factors remain poorly understood because there are only a few reports on genetic associations. We theorized there might be an association between the grade of tinnitus distress and the genetic background related to psychological factors which might lead us to identify prognostic markers. We enrolled 138 patients who had suffered from tinnitus for over 3 months. Using Tinnitus Handicap Inventory (THI) scores, we examined the association between tinnitus distress and a genetic background related to depression or anxiety. A significant association between single nucleotide polymorphism rs131702 of the Breakpoint Cluster Region (BCR) gene and the severe THI score was identified. In addition, there was an association with the severity of the State-Trait Anxiety Inventory, an index of state anxiety severity. No association was found with the Self-Rating Depression Scale, an index of depression severity. It is reported that rs131702 of BCR in Japanese patients are related to bipolar II depression characterized by fluctuation between abnormal mood states of mania and depression. Our results indicate that rs131702 of BCR is independent of depression in this study and is, therefore, a prognostic factor unique to tinnitus. We conclude that the severity of tinnitus is associated with genes related to depression.

Full article: https://www.nature.com/articles/s41598-020-69467-0

 

[Frédéric]

The rs6265 polymorphism might not affect the secretion of BDNF protein directedly

Tinnitus is an auditory disorder with ringing, buzzing, and hissing of the ears. Tinnitus occurs by perceiving sounds without attribution of external sources and has various risk factors such as loss of hearing, anxiety, depression, and hypertension. While there is a wide range of factors contributing to tinnitus, the precise molecular mechanism is poorly appreciated. Recent studies on tinnitus evoked potential evidence for the contribution of neurological factors in the progress of tinnitus. Here we used PCR-RFLP to assess a single nucleotide polymorphism in Brain-Derived Neurotrophic Factor (BDNF), which substitutes valine 66 to methionine amino acid (known as the rs6265). The BDNF functions in the development of the inner ear and has a crucial role in the central auditory pathway. The rs6265 causes a functional missense mutation that inhibits the secretion of BDNF from the synapses. Here we tested 127 Iranian subjects from the city of Yazd (90 normal subjects and 37 patients) to analyze the rs6265 polymorphism in the BDNF gene. Our analysis found no association between the investigated polymorphism of the BDNF gene and the presence of tinnitus in Iranian patients. Further, we proposed a hypothesis that SORT1 and TRAF6 might facilitate the BDNF secretion, and this process might be independent of the rs6265 polymorphism. Therefore, this study indicates that other genetic factors may be relevant to the development of tinnitus disease.

Full article: https://www.sciencedirect.com/science/article/pii/S2214540020301316

 

[Frédéric]

Well I don't get how KCNQ1 can be at the same time a gene and an ion channel.

Association Analysis of Candidate Gene Polymorphisms and Tinnitus in Young Musicians