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  • Users: NikoD
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  1. NikoD

    Akouos — A New Company Focused on Genetic Hearing Loss

    I'm excited about this because, if true, it's the only time any therapy has been able to target hair cells. If they establish a working vehicle, it opens the door to delivering different things. So far, no one has been able to demonstrate a working delivery mechanism in humans, only animal...
  2. NikoD

    New Theory: TMD the Cause of Tinnitus

    This is a fascinating thread. I'm deep-diving into a publication I read about the connection between temporomandibular disorders and hearing/balance issues. To summarize, it suggests TMJ dysfunction may impact the cochlear through various mechanisms because of its proximity - such as sudden...
  3. NikoD

    Audion Therapeutics Trial

    It ruined my day mate. Mice seem to have life easy.
  4. NikoD

    Audion Therapeutics Trial

    Not great news for LY3056480 and hearing regeneration therapy. I hope some of the other trials pull through. → A phase I/IIa safety and efficacy trial of intratympanic gamma-secretase inhibitor as a regenerative drug treatment for sensorineural hearing loss
  5. NikoD

    AudioCure AC102 to Treat Hearing loss and Tinnitus

    Cheers. Looks like I completely misread the ClinicalTrials page. I will do better next time.
  6. NikoD

    Evidence of Cochlear Neural Degeneration in Normal-Hearing Subjects with Tinnitus

    I think we need an activism thread so US / UK / EU members can reach out to their political representative's with a templated letter, something about funding and research, fast tracking. Maybe there's already a thread? It would be good if all politicians were aware of how widespread the issue...
  7. NikoD

    Akouos — A New Company Focused on Genetic Hearing Loss

    They used a viral vector as their delivery mechanism to inner hair cells to change genomic code (gene editing) which restored hearing. The child lacked a specific protein that enables hearing. It was not regeneration of any cells but that's no reason to be disheartened by this. Breaking this...
  8. NikoD

    Akouos — A New Company Focused on Genetic Hearing Loss

    I was just about to post this but you beat me to it. From Lilly's website: This is potentially the BIGGEST news for hearing research in human history... I can't contain my excitement! Amazing if true, we might for the first time have a cure for sensorineural hearing loss... :woot: The bit...
  9. NikoD

    Rosa Canina, Urtica Dioica and Tanacetum Vulgare Herbal Combination in Treatment of Tinnitus

    Many compounds we see in pharmaceuticals are research derived from natural compounds, and/or molecular structure modified to be more potent. I wouldn't exclude herbals completely, however definitely approach with skepticism. NAC, Vitamin Bs and many known otoprotective 'things' are 'natural'.
  10. NikoD

    Rosa Canina, Urtica Dioica and Tanacetum Vulgare Herbal Combination in Treatment of Tinnitus

    This is a good response to give. If it was snake oil, they'd claim it fixes everything. I like the degree of humility here.
  11. NikoD

    GW-201 aka Tetrandrine (TET) by Gateway Biotechnology (NEOMED's Jianxin Bao)

    Thanks for posting this! The data seems very good. There have been many companies that have failed in this space but, given the people behind this + their backgrounds, it inspires a bit of confidence and hope. Let's see how the clinical trials go.
  12. NikoD

    Anida Pharma AP-001 — Age/Noise-Related Hearing Loss

    Very interesting, but I can't see anything hearing loss related on Anida Pharma's website at all.
  13. NikoD

    Sensorion's New Drug: SENS-401

    10 dB is a lot. 3 dB is the doubling of air pressure/sound.
  14. NikoD

    Inner Ear Hair Cell Regeneration — Maybe We Can Know More

    STR001 reached Phase III. If efficacy and endpoints weren't met, they'd have pulled the trial in Phase II. It would be nice if anyone from the clinical trials was around here haha, or if we could get a response from the company which is still showing active and maybe in the late stages of...
  15. NikoD

    AudioCure AC102 to Treat Hearing loss and Tinnitus

    Me too. Phase 2 will prove if their models translate to humans. However, after reading some the literature I'm skeptical as AC102 seems to just be Prednisolone delivered through intratympanic injection (source). And other clinical trials using Dexamethasone (a stronger drug) such as NCT00097448...
  16. NikoD

    AudioCure AC102 to Treat Hearing loss and Tinnitus

    The trials are limited to those with SSNHL that occurred less than 120 hours ago. I still don't know how this compound works. Phase 2 is trying to determine if it works better than corticosteroids in humans. We do see more evidence that those with tinnitus may have had some type of dysfunction /...
  17. NikoD

    AudioCure AC102 to Treat Hearing loss and Tinnitus

    Recruitment of Sudden Hearing Loss Patients for Clinical Trial: Novel Compound AC102 Outperforms Corticosteroids Preclinically AudioCure Pharma Awarded for Therapeutic Small Molecule for Hearing Loss Personally for me it has to be this part: More and more research suggests hair cells aren't...
  18. NikoD

    Evidence of Cochlear Neural Degeneration in Normal-Hearing Subjects with Tinnitus

    Spiral Therapeutics' drug delivery system to the cochlea which lasts a controllable time, in my opinion, will be one of the biggest breakthroughs and progress in hearing therapy. Yes, it's no cure but it's a key step. We could see trials using Spiral Therapeutics' system that delivers drugs in...
  19. NikoD

    Otonomy OTO-413 — Treatment of Hidden Hearing Loss

    I've been following this and other research news for some time and, like others, I am disappointed. Just some thoughts on this for whatever it's worth. Reading the literature suggests there is an issue of maintaining quality drug release into the cochlea. I remember a specific paper that used...
  20. NikoD

    Regeneration of Cochlear Synapses by Systemic Administration of a Bisphosphonate

    Thanks for the article. It seems interesting. I was diagnosed in early 2010 and had a Stapedectomy in 2014. I've had frequent follow-ups since I noticed a big change in hearing. In hindsight I didn't have enough follow-ups before, which may have helped spot the issue earlier. It was really...
  21. NikoD

    Regeneration of Cochlear Synapses by Systemic Administration of a Bisphosphonate

    I recently started taking Risedronate 35 mg weekly. It's been around 8 weeks since I began. I believe it has helped calm my tinnitus somewhat. It has not gone entirely but I no longer get periods where the tinnitus is extremely loud, it's much more stable. I go over and explain some of my...
  22. NikoD

    Steroids: Prednisone / Dexamethasone / Others (Oral and Intratympanic Injections)

    These two steroids can be a saviour for people with sudden hearing loss. However, I believe taking them just because you have tinnitus is a bad idea. These drugs can also increase the risk of osteoporosis which is associated with hearing loss.
  23. NikoD

    Sound Pharmaceuticals (SPI-5557 & SPI-1005)

    It's in the exclusion list for very good reason, 1) so to not complicate the trials, 2) the drug will ultimately be licensed for a specific use, otosclerosis is not its intended use. If the drug is approved and shows a way of reducing bone remodelling in the cochlea, it could be used off-label.
  24. NikoD

    My Unilateral Tinnitus Seems to Go Away When I Spray Olive Oil in Ear

    Do you remember how you acquired the hearing loss apart from the headphones? Does hearing loss run in the family at all? Instead of microsuction, next time you could opt for removal by a specialist who uses medical instruments to remove the wax. I would also recommend going to a specialist...
  25. NikoD

    It's been wild, just keep our minds and bodies healthy for one day when there's a golden cure...

    It's been wild, just keep our minds and bodies healthy for one day when there's a golden cure we'll have the rest of our health to enjoy it with
  26. NikoD

    Sound Pharmaceuticals (SPI-5557 & SPI-1005)

    There's evidence Ebselen is a potent anti-osteoporosis agent. Cochlear otosclerosis is the demineralization of the cochlear bone and bony structures near the spiral ganglion cells, and hyper vascularization inside the cochlear (potential angiogenesis induced by the bone remodelling processes -...
  27. NikoD

    Sound Pharmaceuticals (SPI-5557 & SPI-1005)

    Thanks for posting this. I've looked at the literature and it seems extremely interesting. It could possibly even help with slowing cochlear otosclerosis too.
  28. NikoD

    Regeneration of Cochlear Synapses by Systemic Administration of a Bisphosphonate

    @paul mclean, do you have any update on your progress with Zolendronate?
  29. NikoD

    Can a Chicken Cure Hearing Loss and Tinnitus?

    Yes. The research shows greater success in regenerating IHC in young mice I believe. However I think there are now some variations in the methods used to cause regrowth of IHC. One of which if I recall correctly was the inhibition of the Notch signalling path way (I don't claim to have the...
  30. NikoD

    Can a Chicken Cure Hearing Loss and Tinnitus?

    Well yes. Scientists / Researchers are focusing their efforts to supporting cells inside the Cochlear. OHC (Outer Hair Cells) support the Inner hair cells needed for hearing. And amazingly they've shown us Mammals can regenerate Hair cells, Read this publication (Feb 2014)...
  31. NikoD

    AM-101 TACTT1 Results Released

    Good on you. I myself would love to participate in curing my own T and Otosclerosis using non-surgical methods.
  32. NikoD

    Can a Chicken Cure Hearing Loss and Tinnitus?

    I've been reading "In 10 Years" often for many projects. The goal for some of these initiatives is to set-up some short to long term funding, I don't want to question the intentions for some of these initiatives but its hard not to. Recently it looks like drug companies and perhaps other...
  33. NikoD

    Can a Chicken Cure Hearing Loss and Tinnitus?

    Looks like trials have already started! http://www.newscientist.com/article/mg22229662.400-deaf-people-get-gene-tweak-to-restore-natural-hearing.html#.U1rWlvldV8F I posted a few months ago of potential delivery methods to the Coclear and seems like Gene therapy is being used! Will be...
  34. NikoD

    Deaf People Get Gene Tweak to Restore Natural Hearing

    Deafness is broad. This news is exciting and I have every hope something positive comes out of it and other work like it by other researchers and Scientists.
  35. NikoD

    Can a Chicken Cure Hearing Loss and Tinnitus?

    Two members of HHF's Hearing Restoration Project (HRP) discuss how a chicken can help us understand how to a cure for hearing loss and tinnitus in people.
  36. NikoD

    Stanford Researchers Develop New Technology to Study Hearing

    December 3, 2013, Source: Stanford Bio-X researchers develop new technology to study hearing Interesting and comforting to see new developments. This probe may be used to aid hearing cell regeneration and better understand how the cochlear hair cells work in their normal functioning state.
  37. NikoD

    New Funding Opportunity for Tinnitus Research / Investing in Tinnitus Research

    Finally. A crowd sourced project to treat an ear related defect! Have been hoping to see or start something like this for a while. I hope this will spread to other fields and ear related diseases like Mineres disease, Sensor neural hearing loss. This way, the funders (us!) can have an...
  38. NikoD

    Nanomedicine to Treat "Hard to Reach" Deafness

    Source: No Cookies | Herald Sun I am delighted to see progress in this field. Hopefully opens new doors on how we treat NIHL and Conductive hearing loss. This could mean treating hearing loss without the need for surgery and preventing hearing loss in many cases . Once scientists learn how...
  39. NikoD

    Otosclerosis and Tinnitus

    After reading how MIT are researching the use of nanotechnology and bone-repair surgery. I began searching to see if I could find any papers or research on using Nanotech for Ostosclerosis. Nanotech is currently in its early stage. Ostosclerosis is a condition which causes hearing loss and is...
  40. NikoD

    Inner Ear Hair Cell Regeneration — Maybe We Can Know More

    I like HHR foundations approach to hearing loss and tinnitus. Make it sexy as the stigma surrounding it seems to be - "it only occurs at old age". Obviously not the case any more as it seems to be happening more and more at a younger age (Like many on this forum!). Looks like they had a little...
  41. NikoD

    Inner Ear Hair Cell Regeneration — Maybe We Can Know More

    The 10 Year plan to understand some of the blocks in place preventing inner hair cells from regenerating by themselves.
  42. NikoD

    Inner Ear Hair Cell Regeneration — Maybe We Can Know More

    Excellent . Thanks for posting that clip, I don't think I have come across it. It would be nice to know if Dr Andrew K. Groves has made any progress, with the time that has elapsed from when the conference was done (2011) till now, one would believe there has been some major discoveries. Maybe...
  43. NikoD

    Is There a Monopoly on Hearing Related Health Issues?

    A well informed individual is capable of knowing the obligation that exists between the stakeholder and shareholder. I have no interest in maintaining any discussion about this as it diverts attention about the topic. Any person who feels it requires a 'leap of faith' to believe these principles...
  44. NikoD

    Is There a Monopoly on Hearing Related Health Issues?

    Stem cells could work, useful for areas in the body where normal regeneration is impossible. Stem cells could be some distance away with the current state of funding etc. Scientists / specialists think there is a better therapeutic method to regrow cells for our cochlear: The cochlear has...
  45. NikoD

    Is There a Monopoly on Hearing Related Health Issues?

    I often come across articles highlighting this. Last I read, over 40% of veterans came back with some types of hearing related problem, majority noise induced. I'd hoped with the large number of veterans returning, we'd have a bigger reason to try and develop a better solution for those...
  46. NikoD

    Is There a Monopoly on Hearing Related Health Issues?

    You have overlooked that this industry may want to continue or "survive" the next 5-10 years - just like any other. If IHC cell regeneration was impossible, there would be no discussion. But thankfully it is and the question changed from if to when. The recent research which surfaced has the...
  47. NikoD

    Inner Ear Hair Cell Regeneration — Maybe We Can Know More

    The Genetics of Hair Cell Development and Regeneration Andrew K. Groves,1,2 Kaidi D. Zhang,3 and Donna M. Fekete3,4 / (Volume publication date July 2013) Sensory hair cells are exquisitely sensitive vertebrate mechanoreceptors that mediate the senses of hearing and balance. Understanding the...
  48. NikoD

    Inner Ear Hair Cell Regeneration — Maybe We Can Know More

    Here is a lecture done in 2011 - Touches on hair cell regeneration.
  49. NikoD

    Is There a Monopoly on Hearing Related Health Issues?

    On the contrary, research has been done on smaller mammals (mice) to regrow inner hair cells (IHC's) with some success. Shortly after researchers exposed the mice to drugs or prolonged exposure to loud noise to purposely damage hair cells in these mammals, much like how hair cell damage occurs...
  50. NikoD

    Inner Ear Hair Cell Regeneration — Maybe We Can Know More

    Notch signalling pathway inhibitor
  51. NikoD

    The Search for a Cure (Responses from Dr. Roland Schaette)

    I believe this is the case. Stretched funding. The longer these people have jobs.
  52. NikoD

    Inner Ear Hair Cell Regeneration — Maybe We Can Know More

    In relation to Inner ear hair cell regeneration specifically Targeted Delivery Methods: - Nanotechnology Using nano drug delivery to the inner ear. I believe this has been done recently (I will try and find the article) - Gene Therapy (Viral vector) Payloads - Notch Inhibitor (e.g. A...
  53. NikoD

    Inner Ear Hair Cell Regeneration — Maybe We Can Know More

    Thank you for this, was just about to post a thread on all the recent findings on this topic.
  54. NikoD

    Is There a Monopoly on Hearing Related Health Issues?

    I would love some second opinions on this. I have been suffering from Tinnitus and Hearing loss for almost a year now. My Tinnitus affects my left ear and is very loud, I have also lost 80-90% in my left ear. I am in my early twenties. The industry which specialises in selling solutions related...