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XEN-496 Phase III trial is supposed to start before the end of 2020 Kv7 potassium channel modulator, is a proprietary pediatric formulation of the active ingredient ezogabine being developed for the treatment of epilepsy XEN1101 currently in Phase 2b “X-TOLE”, topline data is anticipated in...

Xenon Pharmaceuticals Receives FDA Feedback and is on Track to Initiate XEN496 Phase 3 Clinical Trial for the Treatment of KCNQ2-DEE Before Year-End October 8, 2020 Positive Opinion Received Supporting Orphan Medicinal Product Designation in Europe for XEN496 for the Treatment of KCNQ2-DEE

A New Buzz for Tinnitus—It’s in the Genes! Christopher R. Cederroth, PhD; Natalia Trpchevska, MD; Berthold Langguth, MD, PhD Novel Risk Loci in Tinnitus and Causal Inference With Neuropsychiatric Disorders Among Adults of European Ancestry Royce E. Clifford, MD, MPH; Adam X. Maihofer, MS...

BSHAA webinar video - Why is there no cure for tinnitus (with captions) - David Baguley, University of Nottingham

Is anyone taking part in any of these online support sessions by the BTA? An introduction to the solution-focused approach - free of charge, 9th Oct This session is all about the solution-focused approach to tinnitus, an effective and increasingly recognised therapy in psychological circles...

Association between Hyperacusis and Tinnitus Christopher R. Cederroth, Alessandra Lugo, Niklas K. Edvall, Andra Lazar, Jose-Antonio Lopez-Escamez, Jan Bulla, Inger Uhlen, Derek J. Hoare, David M. Baguley, Barbara Canlon, Silvano Gallus Abstract Hyperacusis was associated with any tinnitus...

They're uneducated in regards to hyperacusis and can't imagine a condition that makes normal everyday sounds dangerous to a person. Many ENTs rarely see people with hyperacusis, yet alone severe hyperacusis. Also: "Not many patients would be happy to hear that there’s a lag of about 17 years...

"Clinical advice rarely comprehends setbacks or the risk of making the condition worse. These findings provide key characteristics that need research to understand the underlying mechanisms. Importantly, clinicians should exercise caution at making such ambiguous claims as ‘everyday noise can’t...

A simple PDF file would be great. You can easily download it, skim through it and send it to other people. A video would be nice as well and Tinnitus Hub could share it via their social media accounts. I'd say simple and succinct but not too watered-down. If certain parts can't be shortened...

About the study duration of tinnitus isn't mentioned type of tinnitus isn't mentioned (e.g. chronic or intermittent) type of hyperacusis isn't specified type of hearing loss isn't mentioned didn't use THI or TFI but TQ they don't explain what they mean by "psychoeducation concerning tinnitus...

NIH awards researcher $972,613 for his drug research aimed at treating & preventing tinnitus Jianxin Bao, researcher and professor of anatomy and neurobiology at Northeast Ohio Medical University (NEOMED), received a federal grant to support further research and development of the prevention...

XEN1101 (in Phase 2) Dr. Pimstone continued, “Within our XEN1101 ‘X-TOLE’ Phase 2b clinical trial, as with other trials ongoing in our industry, we are seeing a significant reduction in new patient enrollment for numerous reasons related to the COVID-19 pandemic; therefore, we have adjusted...

I only know about the link I posted above, I'm not sure if they're going to upload the webinar. Yes, she mentioned that other researchers saw a reduction in tinnitus loudness in tDCS trials.

It's supposed to reduce tinnitus distress, not loudness.

Completely agree. Tinnitus subtypes research also seems based on the idea that we already have effective treatments and just have to find out who they work for so that we can sort people into groups. I remember reaching out to the authors saying that I'm worried this paper might harm severe...

Thank you for asking all these great questions! No. There's an overwhelming focus on tinnitus distress which is understandable since we can't reduce it yet but this has lead to misconceptions such as loudness not being important. This is in part due to the Cognitive Model of Tinnitus. There's...

The funny thing is I could apply his statement to my visual snow. When I'm stressed, I usually notice my visual snow more. In the beginning, the VS symptoms even scared me but reminding myself that it's "just" visual snow helped me to calm down and made it less distressing. My brain can now even...

Dr. Hashir Aazh's new video "Other studies show that when tinnitus-related distress and anxiety is minimised, tinnitus loses its significance and it is more likely for it to fade away to the background" "Our study showed that the amount that people get annoyed by their tinnitus is the key...

From The Visual Snow Initiative: "A NEW #VisualSnowSyndrome study is here! Read more information here and stay tuned for more updates! The first series of introductory videos is available now at here"

While the majority gets better, it's not 99%. I don't know if you meant this literally or more as in "the vast majority is fine"! :D Just wanted to share some information about how many people are affected because numbers-wise, tinnitus isn't a small issue. It's a much bigger issue than many...

I couldn't find a thread specifically about XEN-496 but here's a thread about XEN-1101 which is "a differentiated Kv7 potassium channel modulator, for the treatment of epilepsy and potentially other neurological disorders" and currently in Phase 2 and XEN-496 is also being mentioned. "XEN1101’s...

Unfortunately, that's a question we can't answer for sure yet. Tzounopoulos: "I think our drug would work in cases where there is hyperactivity of the central nervous system. Also, what I believe about our drug, and I cannot predict yet in which category it is going to work, but we are working...

What kind of hyperacusis research would benefit from excluding people with hearing loss? The British Tinnitus Association: Researchers from the University of Nottingham would like to invite you to contribute to an important new research study on hyperacusis! Who can take part? You may be able...

Tinnitus Does Not Interfere with Auditory and Speech Perception After controlling for age, hearing loss and stimulus variables, we discovered that contradictory to the widely-held assumption, tinnitus does not interfere with perception of external sounds in 32 out of the 36 measures. We...

Salzburg Brain Dynamics Lab - Online Experiment (headphone-use required) You suffer from tinnitus or know the complaints it can cause? Then contribute now to the further research of this phenomenon by participating in our online experiment. Who are we looking for? Everyone with or without...

Brainbox Initiative Webinar: tDCS as a Treatment for Chronic Tinnitus We are joined by Dr Laure Jacquemin of the University of Antwerp for this Brainbox Initiative webinar tDCS as a Treatment for Chronic Tinnitus. In this webinar, Dr Jacquemin will explore and detail the results of her research...

By Action on Hearing Loss: We're looking for anyone who is deaf, has hearing loss or tinnitus to take part in research to help shape our ideas and be among the first to try new services. You can take part online, via phone or via a paper-based survey. Get involved...

Online Survey: Hearing loss and Tinnitus from Chemotherapy

85 dB is Not a Safe Noise Level to Prevent Hearing Loss The Hearing Journal; Fink, Daniel MD

We just shouldn’t forget that it doesn’t get better for everyone and that there are many long-term severe sufferers whose quality of life won’t noticeably improve until we find real treatments. Especially people new to tinnitus need support and encouragement but we can help them without ignoring...

Altered Topological Patterns of Gray Matter Networks in Tinnitus: A Graph-Theoretical-Based Study Xiaofeng Lin, Yueyao Chen, Mingxia Wang, Chao Song, Bingling Lin, Xiaoping Yuan, Qingyu Liu, Haidi Yang and Ningyi Jiang Results: Tinnitus was found to have increased global efficiency, local...

Associations Between Subjective Tinnitus and Cognitive Performance: Systematic Review and Meta-Analyses Nathan A. Clarke, Helen Henshaw, Michael A. Akeroyd, Bethany Adams, Derek J. Hoare Analyses showed that tinnitus is associated with poorer executive function, processing speed, general...

That's another problem with CBT, the therapist gets to decide what's rational and irrational. When does catastrophizing start? What is fear and avoidance behaviour and what are common sense precautions? Also, the Cognitive Model of Tinnitus clearly states that it's only the emotional reaction of...

The consequences can be far worse though, such as leaving someone feeling more suicidal. Imagine spending hundreds of hours and months on trying these CBT/TRT/mindfulness approaches, which oftentimes tell you that you have to fully believe that they will work for them to work, only to have to...

Are you saying everyone can cure their tinnitus if they just have the right mindset? That's usually one of the aspects of "mind over matter" that people criticise, so while a certain attitude might help to cope a bit better, tinnitus can nonetheless be severely debilitating. I appreciate the...

Thank you for the suggestion but I've already tried these approaches. I'd encourage anyone to try out CBT, mindfulness or other strategies as they might help someone (as long as "mind over matter" isn't being used to downplay how debilitating this condition can be).

TRT is based on many misconceptions that are incredibly harmful to severe sufferers such as: everyone can learn to tune out their tinnitus tinnitus distress is purely due to someone's emotional reaction tinnitus loudness doesn't matter at all Pawel Jastreboff, the creator of TRT, has literally...

Clinical Implications of Chloroquine and Hydroxychloroquine Ototoxicity for COVID-19 Treatment: A Mini-Review Pattarawadee Prayuenyong, Anand V. Kasbekar and David M. Baguley

Suicide, Self-harm Considerations in Holistic Audiological Care Schwartzer, Sarah BA; Parker, Mark PhD This result suggests a statistically significant link between how loud individuals perceived their tinnitus and how likely they were to have had ideations of suicide and/or self-harm in the...

Nothing but respect for Bryan Pollard.

End of 2021? So I'm guessing it's unlikely that it'll be launched in 2022. Maybe 2023, 2024? So at least another three years of no improvements. I don't think I'll be able to endure that.

Gender-Specific Differences in Patients With Chronic Tinnitus—Baseline Characteristics and Treatment Effects Uli Niemann, Benjamin Boecking, Petra Brueggemann, Birgit Mazurek and Myra Spiliopoulou

People like her will say whatever they can to protect themselves, validate their logic and continue to make more money. But she isn't actually basing her views on science. She will say whatever she can to lure desperate people into spending money on her "treatments". On an emotional level what...

Why doesn't this surprise me at all? This is what TRT does - it spreads harmful misconceptions and further harms severe sufferers. It's horrifying to know that he is a consultant surgeon at London's Royal National ENT Hospital. But thank you for finding it! "There are people who say they have...

How I beat my own tinnitus, by the specialist who treated himself People with tinnitus miss out on help as their doctors think it can’t be overcome Vik Veer, consultant surgeon at London's Royal National ENT Hospital, disagrees As his experience shows, it is possible to out-smart the constant...

Jastreboff really isn't the best source of information when it comes to treating tinnitus. (at least imo) :D But I agree that this is how we would treat it and try to help someone.

Relationship between headaches and tinnitus in a Swedish study Published: 22 May 2020 - Alessandra Lugo, Niklas K. Edvall, Andra Lazar, Golbarg Mehraei, Jose-Antonio Lopez-Escamez, Jan Bulla, Inger Uhlen, Barbara Canlon, Silvano Gallus & Christopher R. Cederroth When focusing on subjects with...

"Although some treatments are available, such as counseling (to accept tinnitus symptoms) and noise-generating devices (to help tune out tinnitus), these treatments don’t work for everybody." :thankyousign:

Dr. Gans said people who are bothered by tinnitus have a certain type of personality, they’re just needlessly “holding onto something”. She goes on to say it can be pushed in the background - which just isn’t possible for everyone. Throughout the video, she implies that everyone can reach a...

What would you want from a pill for tinnitus? Researchers at @UCLEarInstitute want to know what your expectations would be. Find out more about the study and link to the survey here. Please note that the team are NOT developing a drug themselves.

Done! :D (Seems like the link is working now)

Sex Differences in the Response to Different Tinnitus Treatment Introduction: Tinnitus is a complex symptom requiring a thorough multidisciplinary assessment to construct an individual’s tinnitus profile. The Antwerp University Hospital hosts a tertiary tinnitus clinic providing intensive...

There's still a difference between rating a post as funny that you find ridiculous or heavily disagree with and rating a post as funny even though it's just about someone's personal struggles or their hopes for future research and treatments.

How convenient for you to say and we're just supposed to believe it. What matters is that there are people who have genuinely tried TRT and didn't benefit from it or even got worse. You call people negative for far less. Also, calling out organisations that are supposed to represent all...

That's just not the case for everyone, there are people who didn't think treatments would help them, such as TRT or CBT, but then they did benefit from them. Many people also aren't as one-sided as that, a part of them might be sceptical of a certain treatment whereas another part might be open...

This is much more reasonable but usually you write stuff like this:

That's not how you're selling it to people who are new to tinnitus.