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Hey all. Does anyone know the differences between the GABA in XEN1101 and non-GABA in BHV-7000? Does GABA have something to do with tinnitus reduction? Or is it more the Potassium channels? Between XEN1101 and BHV-7000, which would be your best bet?

Hey Kristin! I read about your Tinnitus aggravation after some tests. How have you been lately?

Hi @Carolyn C, unfortunately our hearing is very sensitive as we age. You should visit a very well trained Otologist or ENT. Apart from steroids, which have to be prescribed by a doctor due to weight/height/ background, NAC, Magnesium, and Vitamins ACE can be beneficial as they can help protect...

Hey @BTaylor12. Hubert Lim is Chief Scientist Officer of Neuromod (Lenire) and also Professor of Biomedical Engineering and Otolaryngology at University of Minnesota. So there is a link between both parties.

Did you take any ototoxic medication for your sinus infection? It's important that you check if there is inner ear damage. Additionally, strong sinus infections (as well as otitis media) can change Eustachian tube function (due to inflammation), and can take up to 6 months to work properly...

Congrats @Scrivs007. The forum needs these stories. All the best!

Hi @Jupiterman, tinnitus is a very complex ailment. It is originated in the auditory nerve, but then the brain makes things more complex due to the auditory cortex. It's most important that you protect your ears if the situation calls for it. If you are not exposed to loud noises, and you...

Wearing earplugs 24/7 is not a good idea. I think that you would hear your tinnitus louder, which would hinder your auditory system and brain to habituate and fade the tinnitus volume as much as possible. Earplugs are good for protecting from acute loud noises (concerts, discos, etc), but not...

Hey @DutchMelvin, I am sorry but I am sure you will be fine! I am leaving you some advice (I am talking also from a personal experience): Eustachian tubes take up to 6 months to work properly after strong sinusitis or otitis media (but right now you have two main goals, clear the fluid and...

Does anyone have an update on Dr. Djalilian's work?

Hi! You can do that, and you should do it! Go for a walk in the forest. Paint. Listen to music at a good level. Go to a quiet restaurant. Don't stop doing that. Find nice friends that understand you. Life is about constantly adapting. You will be fine, for sure! All the best.

I doubt it! Quinine causes reversible ototoxicity. But tonic water usually has no more than 80 mg of quinine per liter. So for example 200 ml may have 16.6 mg of quinine. I really doubt that this quantity can affect your ears, it would be very unlikely. You will be fine! You can drink lemon...

Hey @Isaac Ramsay. I am sorry to hear that. Tinnitus is an intriguing symptom, with many causes. It is very important to understand your medical history and the days prior to your tinnitus onset, and also your symptoms. My recommendation would be that you visit a very well trained Otologist or...

Hey @duesseldorf. I am sure you will be fine. It is important to pay attention to what happened when the tinnitus appeared in your case. You are talking about your neck and Aspirin. Aspirin can be ototoxic and cause tinnitus, but in most cases it is reversible. So based on these two events, I...

Hi @WildJello. I am sorry about your spike, but you will be fine, I am sure of it! As @Michael Leigh has suggested, I agree that the first step would be that you visit a very well trained Otologist, Audiologist or ENT. Most important is to understand if your problem is related to any inner ear...

Hey Joanne, have you tried antihistamines? There is a device called Eustachi. It's not available in my country, but I am trying to get it. I am considering Balloon Dilation surgery, still thinking about it. Did your Neti pot spike diminish? Did some fluid get into your ears? Best regards!

Hey looonia! How did your tinnitus spike of the acoustic reflex test evolved? Same story here, an ENT pushed hard and did the test several times. Best regards!

Hey Hamsti, did your acoustic reflex spike subsided in 2021? Best regards!

Hey lolkas! Whoy did your T after acoustic reflex evolved? Best !

Thanos Tzounopoulos is a great guy. I really hope he can find the molecule and is successful in his trials. I would be grateful to think of him as the guy who relieved my tinnitus. Of course, also Dr. Susan Shore. They both represent ethical and the bright side of science.

Same here after my recent ETD issues. I don't know if it has something to do with Swimmer's ear, or if water in the ear drum causes inflammation if you have ETD. Weird!

Hey @EatMoTacos, you can check this PDF document. Most importantly it should be highly absorbable without side effects (headaches, sleepiness, diarrhea... etc). You can try which one works best for you. Hope this helps and best of luck!

My biggest concern is that, after so many failed clinical trials, investors and big pharma shift investment to other ailments. Let's hope not. Good news is that we have alternatives; Dr. Susan Shore, Xenon Pharmaceuticals, Decibel Therapeutics, Neuromod (if they learn and improve Lenire), and...

Hi @AnthonyMcDonald. I have had tinnitus since 2017, due to noise trauma, and have spoken to many people during this time. For example, you can check this paper: Sudden Sensorineural Hearing Loss: Primary Care Update "High dose oral steroids are recommended and should be given as soon as...

Best of luck! You have to know that sinusitis, if not taken care properly, can affect your ears and increase or modify your tinnitus. In my opinion, because Cefdinir is not considered ototoxic, I would take it as soon as possible. If you are still worried, talk to your doctor and let him...

Hi @EatMoTacos. It is safe. You shouldn't worry. You can speak with your doctor. Take NAC and Magnesium, or some vitamins (Vitamin ACE, Zinc), to protect your ears, while you take it. In the literature there is no evidence at all that Cefdinir is ototoxic. I would be more worried about...

Hi @AnthonyMcDonald. It is not bad advice, there is an open window, the soonest, the better. But even at 1 month after onset you can see some benefit, and that is much better than nothing. Steroids have their risks, and should not be taken on your own, but the risk is worth it in case there is...

Hey! Even if the onset was a month ago, I would go and see a good otologist. You may try some treatment, such as Prednisone, or NAC, Magnesium + vitamins ACE. It is worth a shot and you lose nothing by trying. Maybe also do an extended (high frequency) audiogram. Best wishes and stay strong!

Hi @Sugarpuddle, have you done the complete set of ear tests? It would be wise for you to do a high frequency (extended) audiogram, tympanometry and Eustachian tube test, as well as maybe OAE. Let me know your results! Best wishes. Maybe you don't have inner ear damage and that would be great...

Hi @Joanne Philps, I hope you are doing great! How did your tinnitus react to the Neti pot? I also had a very bad spike after using NeilMed Sinus Rinse. After 2 months i am starting to do much better, but my Eustachian tube seems very inflamed after this episode. It would be great to hear from...

You might have a very mild tinnitus, and all the inflammation on the sinuses and Eustachian tubes can make you hear it stronger. Best thing is to have a complete audiogram, checking the high frequencies as ototoxicity usually affects high frequencies, and also have an Eustachian tube test...

I hope so @Diesel. Even if the effects are not that big, but just moderate/slight improvements, if the treatment is safe, I think it should be approved. It would be a pity for Frequency Therapeutics to shut down. Another company with tons of knowledge and research gone.

I think it is a pity, that even with little improvements, these companies may not be able to launch their products into the market. I think of Otonomy. There is a lot of knowledge within these companies, scientists and research. Even if something provides only a small amount of improvement, it...

Thanks DeanD. How long have you had that 70 dB hearing loss? I have both inner ear damage (tinnitus) and ETD. Basically ETD makes the whole ear not function well, so you can hear your tinnitus more, that is why some days are worse than others. That is why the treatment is based on cleaning the...

Hi DeanD. You should have extended audiogram test covering high frequencies, Eustachian tube test, tympanometry test and review the results with an Audiologist and an Otologist. Make sure they understand tinnitus and the auditory cortex well. It is important also to see if you have a retracted...

It is highly improbable that a simple dog bark can damage your hearing. You will be fine! Obviously some people's ears are more sensitive than others'. Two people can be at the same concert, one get tinnitus, the other one not. But it's very unlikely a dog bark damaged your hearing. Some...

I think Lenire works to some extent. The fact that some people who have tried Lenire say their tinnitus doesn't bother them as much anymore, for me, means some amount of success. Probably there are people for whom Lenire has worked but who are not here.

Hello @Fatar760! I hope you are doing fine! I am having a situation like yours after a sinus rinse. Since end of december i did a Sinus Rinse, water got trapped in my eustachian tube and my already existing T has gone crazy. It has gone better now. How did yours evolve? Best regards!

Hello Texana! I hope you are doing fine! I am having a situation like yours after a sinus rinse. Since end of december i did a Sinus Rinse, water got trapped in my eustachian tube and my already existing T has gone crazy. It has gone better now. How did yours evolve? Best regards!

Same here. I definitely think bimodal stimulation will be the way to go. Regenerative medicine is still far away, and for many other diseases as well. I hope to be wrong and FX-322 to be a success. But right now I believe all these devices will be the best shot for us.

Thanks @Sufferer1221 a lot for your answer, and I am so glad you are doing great! Today I had some exams. I had a complete audiometry and otoacoustic emissions. Fortunately, my tests came up all good without any change from the ones I had two years ago. So yes! This is an inflammation /...

Thanks @Keydet19. Unfortunately, for some of us, a sinus rinse can be dangerous, as because of Eustachian Tube Dysfunction, liquid can get trapped, not flow properly and inflame the whole ear, and create a spike, which, in my case, happened after a NeilMed rinse :( So from now on, in my case...

Ambroxol is a mucolytic and antioxidant. If you have ETD, sinus or any mucus buildup, it is a good drug to make the mucus more liquid and easier to clean the respiratory airways.

Thanks a lot for your reply @Sufferer1221. Great news! It seems that you are almost 100% recovered, and congrats for your recovery and progress. How long did it take for all to heal? I agree with all you are saying. I did hearing tests and they came back perfect, but I have been diagnosed with...

Hi @Sufferer1221, another sufferer here. I have had tinnitus since 2017. I've been pretty habituated to it since some years ago. 1 month ago I did a NeilMed sinus rinse and my tinnitus has gone crazy. Some days it is very high, some days very low. When I lie down for some time, it is aggravated...

I still think, apart from Prof. Tzounopoulos, that the best treatment for the mid term will be neuromodulation, and probably long term will be pharma and Frequency Therapeutics. But something is saying me they will need to do more research. But neuromodulation looks promising.