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10 years to get to a phase 2, god damn. What a joke Hough is when it comes to actualizing their products. They should have spun their research department off into its own biotech a long time ago, because holy shit, this is just embarrassing. and this is coming from someone who believes in the...

Hey Steph, this could be an endocrine issue. Can you get checked out for things like Cushings? Cataracts and hair loss are sometimes symptoms, and it’s better to treat sooner than later. I’m sorry you have to deal with this on top of the t. Having more medical problems get thrown at you is...

Yes, I still do. Nothing has really changed.

keith you have beautiful eyes.

@Ed209, this is super random but can you pick a number for me between 1 and 15. I promise it’s not for something weird.

Holy shit Zug, you got promoted from evangelist to lawyer, and you didn't tell us? wtf man, we would have thrown you a party.

I’ve been using Discord more and more to distract myself, but there’s only so much I can do before the walls start closing in around me again...

Say what now Lol no. I think you missed 99% of the thread tbh.

For anyone curious, what that guy is describing is the MOC reflex. Basically you have a feedback loop where sound enters the ear, runs through the OHC via mechanism vibration, transmits to the IHC where the signal then becomes chemical along the auditory nerve, and is finally shuffled across...

Interesting. Good to know my dad is in hell. TIL.

This is giving me strong Tynnyfer vibes.

I think too some people, myself included, find solace in research. It makes me feel informed, which by extension makes me feel empowered. Others - like my mom - find it more anxiety inducing. We both have severe tinnitus but seek refuge in vastly different sources. She even knows about the...

It absolutely sucks doesn’t it. Every medical procedure feels like navigating a mine field when you have shitty cochlear problems. The person who received the local didn’t have any hearing problems, hyperacusis or otherwise. But I meant more that they seemed to tolerate the local pretty well...

You said 45 degree angle correct? All four of mine were growing in at 90 degree angle so fully impacted on all sides. For my case, I had to get them removed or face severe occlusion problems later on in life (not just cosmetic) due to my small jaw. I had mild tinnitus and it didn’t affect it at...

Yep, here they be. Relation of focal hair-cell lesions to noise-exposure parameters from a 4- or a 0.5-kHz octave band of noise Distribution of focal lesions in the chinchilla organ of Corti following exposure to a 4-kHz or a 0.5-kHz octave band of noise I believe the researcher wanted to...

Who wants to tell him?

Wow, just wow. Absolutely phenomenal. Thank you for this. I wish something like this would be available in ENT offices. Also might I suggest an addition? PIPE-505 also regenerates OHCs in small, but not completely insignificant amounts (at least per their preclinicals). It was enough for them...

I believe in you Zugzug. I also found leaked footage of you and Diesel purchasing that RV.

It was a cat xD From the CATS musical. I highly recommend the old version. You can find it on YouTube - it is a trip.

Well yeah, no shit. What did you think I meant? That Diesel, Zugzug, FGG, and Aaron91 would be concocting makeshift FX-322 out in a random back shed in the middle of Nowhere, Nevada because Frequency Therapeutics has no desire to improve their drug formulations? I̶ w̶o̶u̶l̶d̶ w̶a̶t̶c̶h̶...

This is silly imo. Science is heavily concerned with minutiae. Imagine if after the flawed launch of the Hubble Space Telescope, the engineers and scientists on the team said “well, the whole thing is busted. Now it’s space trash.” But they didn’t. They diagnosed the issue, and proceeded to fix...

Ah, that makes sense. What I don’t understand then is why they would say they would move forward with single doses for FX-322 specifically following the results of the preliminary readout, and then turn around and give a vague tweet that might imply they are done with FX-322 development. Unless...

Okay, so I could be completely, utterly off base here. But this weirdly enough sounds like a scheduled tweet to me. I used to do social media for a startup and this is the kind of vague, pleasant nothing I would write months in advance for a scheduled release or drop. It’s actually kind of eerie...

If you can (and I don’t pretend this isn’t extremely hard) I would at least wait until they release that new form of CI that uses light. @FGG mentioned it before on this thread, and it sounds like it’s a substantial jump in implant technology. However they plan for clinical trials in 2025...

Byproduct of improved cochlear input at the proper frequency. If you don’t parse out all the permutations of what “improved hearing” actually is, you will likely misread the data. What’s important is to determine what structure is damaged, and how low it is in the cochlea. Unfortunately, none...

It’s important to understand what structure is being fixed and to what extent, so that we don't keep seeing the same erroneous “I knew FX-322 was never a miracle cure!” posts over and over. If you understand what a drug fixes, you can better understand your chances of the drug fixing you.

This is what really, truly hits me. My worst case scenario was that Phase 2 would show the same benefits from Phase 1, with no real additional improvements. And that Frequency would try to move full steam ahead with the efficacy shown from Phase 1/2, get to market, and then go balls to the wall...

I recommend reading this. Keep in mind, as FGG has said, audiograms do not measure IHC loss. The article is mostly focused on synaptopathy, but it has several very important points regarding the function of IHC: “About 95 percent of sound input to the brain comes from the ear's inner hair...

I wonder if needing the IHC to be regenerated first is due to the specifics of the progenitor activation pathway. Perhaps because it works similar to how hair cells develop in-utero. Without the signal from the IHC, the OHC can’t form. I wish it was possible to watch regeneration in real time...

That makes sense. When they tested above 16 kHz for me it sounded like “shhh shhh”. It wasn’t a pure sine wave. I wonder if that’s part of the calibration procedure. It was a very stark difference too. At first I thought the headphones I was wearing were shorting out.

I wouldn’t use the audiogram as a means of assessing tinnitus improvement. I have substantial notches that match my tinnitus tones. But they don’t show up on an audiogram because they are at very random frequencies. I even have a complete flat line in my EHF at 0 dB, but sweep testing up in...

Interesting question... I suppose it would depend on how afraid you would be about getting “caught” should any discrepancies surface and how aware you are of the blinding process. If you’re unfamiliar with the extent of blinding, you might think that the trialing center (or the researchers)...

Don’t tempt me, I will waste money on this.

After all this (and having read the various - and extremely informative - breakdowns from @Aaron91, @Diesel, @Zugzug and others) I’m still more or less Team Goop. One question of mine is how this might affect the ability to apply for expanded use in the upcoming years. Due to the poor initial...

This is darkly hilarious to me because it’s like they never stop and think “hm, maybe it’s so variable, because I don’t know, maybe some have very loud and unmaskable tinnitus. And those people suffer more than the “oh I turn on a fan and I’m fine” people. What a strange hypothesis right?” As...

Eh? I’m confused about this, not sure why I gave you this impression. I was only speaking from my own experience that waiting for a HL drug to hit market (in any form) is what helps keep me going. This shit is unfathomably hard to deal with. As for FX-322 I posted this before their Phase 2a...

Can we like, maybe not call the drug dead until we have the full readout, and can parse through all the data? Just a thought. I swear this forum sometimes gives me whiplash. If the drug shows some efficacy it’s the greatest Cure in the world!!! And if it hits difficulties, well then it’s...

I actually fear I might have been unknowingly complicit in the whole fraud thing, if that turns out to be truly legitimate. Most people were not given the reason for their rejection from the Phase 2a trial, but I was. They point blank told me that although my audiogram qualified me, my WR...

Columbia is actually working on this. 3D-Printed Microneedles Create Precise Perforations in Human Round Window Membrane in Situ 3D-Printed Microneedles Open Ears to New Treatments

I hope this isn’t coming across as me making light of the situation... I, like several others, did not have high hopes for greater penetrance (although a part of me was really hoping they’d push to 5 kHz or so with repeat dosing), but I truly thought there would be 30-40 dB gains in the EHF and...

The only data point I can think of off-hand is Ebselen, which becomes far less effective for ear inflammation at higher doses. But that drug is unfortunately not specifically targeted to the inner ear nor injected into the middle ear (it just has very high penetrance systemically) so the...

Not in vivo. If we had that kind of diagnostic tool we wouldn’t be working solely around audiograms.

I’m still trying to square away these results with the phase 1 data, because this is all very confusing. I didn’t expect phase 2a data to be astounding (I was almost certain penetrance would still be a problem) but to show no difference from placebo is so vastly different from the statistical...

Yes, correct.

I should clarify. My audiologist didn’t know that this would be submitted as consideration for the FX-322 trial. It wasn’t a deliberate withholding on my part - I was (and still am) in a really terrible mental state and just wanted to get in and out of that office as quickly as possible. So I...

Not necessarily. When I did my word score testing I said “I’m not sure” at several points and then my audiologist increased the decibel level so that I could hear it more clearly. I didn’t have to actually come up with a different word. This was for qualifying though, I’m not sure how they...

Wow... this just breaks my heart... I don’t really know what to say. I wish he could have held out for a bit longer for some of the drugs that are hitting market in the next few years, but severe tinnitus just beats you down so hard I know why he thought there was no other way out.

I unironically do not want him to leave this thread. He is low key brightening my day every time he posts, due to the sheer amount of meme potential he wields.

OMG... I didn’t even realize it was misspelled. My brain straight up auto corrected it...

FX-322 2.0. But in all seriousness, I believe vibrational resonance is being looked in to by a few other companies as a means of drug delivery. It’s been discussed in the past, but this was quite a while ago and my memory is fuzzy. One method was supposed to hit market in 2022... I’ll try and...

Did I miss the meme party?

I believe this quote here is also kind of concerning, and part of the reason why others are giving you a hard time and claiming you have a fundamental misunderstanding of both the drug itself, and the stock market as a whole. FX-322 is not going to be a cure for “capital T” tinnitus. It is one...

@FGG is obviously the most sinister and Machiavellian of our rag-tag crew.

I would also like to know when my beautiful and lonely 7 GME shares will finally land on Pluto, plz and thank you.

To be fair, if you read tinnitus research papers from the 80s and 90s it’s interesting to see quite a few of them say one of the main causes of tinnitus is cochlear damage (i.e. hearing loss), and then in the next sentence go on to describe how unfortunate it is that there is no way to...

Distortions truly do suck...I have them too, the worst ones now being within my own voice and it’s just... god there are no words... I know exactly how you feel. If your thudding is ETD it will clear, but it could be a very slow process. I tried to speed it up with Flonase but had an allergic...