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Now we are talking, TRT, CBT, will help reinforce the state of lessened T through neuroplasticity. Furthermore, the brain is functionally integrated, which means that tinnitus is NOT limited to one specific area of the brain. AUT may work on one area, but psychotherapy will help distribute that...

I am pretty sure suctioning can cause acoustic trauma, which can lead to hearing loss.

@Adam G I think you missed what I wrote you a few posts up: This thread is for AUT, but there are threads on this forums that covers your exact concerns regarding TMJ/Dental.

From my limited understanding it can certainly help if it is due to inflammation, which may be the case for your sister. There is an entire thread dedicated to steroids, I would check it out, very good info there.

@Adam G Also, I am assuming your tinnitus started as of recent; therefore, you should consider steroids such as Prednisone. It might help at the very early stages of tinnitus, and the sooner you do it the better. It is definitely worth talking to your doctor about ASAP.

Impacted wisdom should be extracted regardless of T. In fact, it may very well be attributing to your T. Perhaps extraction should be your first option, and start from there. Proccess of elimination, start with the small things first before jumping into drugs, experiments, and other invasive...

Right? I would take some heartburn anyday over brain piercing high pitched T. At least you can treat the syptomatic issue of heartburn with some otc meds.

So there is definitely a proof of efficacy, and the fact that the T came back after three weeks is extremely insightful. This only further reinforces my belief that TRT type therapies are necessary for effective long term treatment. Neuroplasticity and the integration of neural function is...

@jeannie Your effort is very much appreciated. I'm quite positive that she would completely understand why we are so excited about about a drug that can potentially reduce T by 75% in a little as four weeks. Hopefully she joins us here and offers more insight.

Welcome, and you are definitely not alone in the struggle. Of all the negatives, the positive is that we have T in the age of precision medicine. There are realistic, tangible treatments being researched and developed. If you are losing hope, put faith in science and the brilliance of the men...

Positive news about Autifony...lifted a large burden off my chest; feeling reassured that we won't have to carry this condition our entire lives. @jeannie Thanks for the update Jeannie. Can you ask her one extremely important question please? For how long did she have T before she started...

We are our own God.

That is fine, I think any news about this drug is good news. You would not think it is much, but some people are desperate to hear some news, any news. I have always had hope that AUT is on the right track, but without any solid updates in months some people are losing hope. It is at least...

Welcome to the community. If what you said is indeed true, we are in for a good ride, so strap up the seatbelt everyone...are you currently in contact with this person?? Can you extract more information about his/her positive experience with AUT!?!? How long did he/she take the drug before...

I find your comment extremely ironic, hypocritical, and lacking any sense of critical thought and substance. You even said I called you a racist? When in fact I said you are clearly ethnocentric and xenophobic. Seems like you are projecting. If you do not see why, that is your loss. You just...

@sakrt How are you so ethnocentric and ignorant? You can post all the sources you want but you are completely distorting the information to fit your nefarious world view that Asians are somehow inherently untrustworthy and detrimental to mankind. Which is extremely ironic coming from a Brit or...

@Beowulf Agat @Crazeefiend From my limited knowledge, you might be suffering from eustachian tube dysfunction. Have you had em checked by a competent ENT?

It has been a while since I visited this forum, because personally, constantly lamenting over this whole ordeal was not conducive to habituation. With that said, I am still very much concerned with these research and studies conducted by members of this forum and by pharma. It seems like we...

@jss @Robb To be fair, there's also no evidence from either company which suggests that excess glutamate feedback loop is not possible on a chronic basis. It's completely possible that some T sufferers might actually have slow deteriorating chochlea due to excess glutamate secretion over a...

It's great another similar treatment is being worked on towards the same mechanism as AM-101. Just because "something similar was done before" doesn't make Otonomy's research any less important or useful. They're offering an alternative solution for people that might not respond well to...

This is a very hopeful sign that you as an individual reacts very well to potassium channel modulators for your tinnitus. Hopefully all of us can get the same positive reaction, but the realist in me knows that's probably not likely. There will be an unfortunate number of us that will just have...

I believe that it will vary person to person, perhaps there will be people that meets permanent relief, while others feel temporary relief of their condition so they will have to stay on it for a long time, and for some this drug will have no positive effects. I also believe that the degree of...

@Robb Please do keep us all updated on your progress, it will help yourself and others. Thanks and I truly wish you the best.

@Robb It's too early for regrets, anecdotal evidence suggests what you're experiencing so far is relatively normal, an increase in tinnitus up to weeks following the injections before it goes back to base level, or a decrease in T volume. You have more reason to feel positive that your current...

@Robb This has been discussed in the previous posts in this thread, no one on here can be exactly sure, but there are some logical hypothesis. Simply put, glutamate is released for whatever conditions preceding it, and the neurons memorizes the "hyper-glutamate" state, basically creating a...

Anecdotally speaking your spike should be temporary by all means, I know it is stressing but statistically your T should be going back down to base levels or there should be some improvement.

@cdog I also forgot to comment on the mechanisms which regulates plasticity, do you know if deafferation inhibits the neural functions from doing its job? In this case the regulation of adverse plasticity. After all the death, or disruption of neurons can ruin the ability for them to maintain...

@Robb I really couldn't say based on my limited understanding, but my guess is maybe but probably not, because once the LTP sets in for a long duration and a positive feedback loop is created, and the damage is already done; furthermore, at a certain point the brains plasticity will hold onto...

@111 I still stand behind my point, not only for this instance but for future instances too. I will always wait for clarification before jumping to assumptions, especially if a comment is stated in such a way that it can be interpreted in multiple ways. If Rhea was indeed implying a genuine...

Because it is a big BUT. She has had tinnitus for 11 years, BUT what if it it also comes and goes, would it include or exclude her? For someone so concerned with grammar and semantics, your spelling doesn't do you any justice...just saying, if you want to get on that level...you can think what...

To be honest that doesn't seem to say much. She might be asking what if she has had tinnitus for 11 years but it comes and goes, would that be grounds to exclude her? Let's not make assumptions based on interpretation, perhaps she should make herself more clear. For all we know it might be a...

Well I completely missed that part, in any case, I am quite confident with extended use of a drug like this tinnitus is hypothetically curable. Now for lying to get into a clinical trial...that stuff can ruin the chance for the rest of us.

I completely agree, now I am beginning to believe that with long enough reversal to the point in which the absence of tinnitus becomes ingrained through neuroplasticity, tinnitus can be cured. The only question I have is how long will that take? If I had the opportunity with AUT00063 or even...

@SteveToHeal From what I am studying, neurons are vulnerable to synaptic plasticity, which basically means the ability for synapses of the neurons to strengthen due to repeated stimulation. The longer the pre-synaptic neuron is used to giving off neurotransmitters in our case glutamate to the...

Nope, I emailed them Friday, and they're closed on Saturdays and Sundays. I have to wait until Monday for his response.

No problem, and don't be sorry cause unexpected shit happens to anyone under any circumstance. Hope your treatment works out, and make sure you get documentations for everything your study doctor says. He might forget what he said two weeks ago when he himself didn't note everything for himself.

Tinnitus isn't believed to be solely due to the brain, AM-101 is targeting the NMDA receptors in your ear, preventing the overreaction of the immediate byproduct (glutamate) of whatever dysfunction that you may have. The damaging of the cells in your ear due to glutamate might be causing all...

@Marius T From my limited understanding from psych studies and Google, there is a connection between stress and increased glucocorticoid secretion which in turn raises extracelluar glutamate levels, glutamate is considered to be a naturally occurring neurotoxin at concentrated levels, this is...

@attheedgeofscience I have just mailed them about further details regarding my case, and that I would like to remain as a candidate for AM-101. All I thought of while I was writing the email was, "why did I NOT get everything on paper or recording" such a shame, because without these...

I am extremely sorry for what the Chinese clinic put you through, I would steer clear of China, but I do understand they're leading the world in many aspects of future medicine. From what I remember, the doctor did mention the fact that it is usually recommended for his patient going through an...

@Rube With AM-101 out of the question, I am going back to the drawing board - tinnitus is not a disease it is a symptom. I will slowly but surely tackle every possible root of my symptom. Through deduction hopefully I can reach a probable conclusion, my recent MRI shows no abnormalities in my...

Although AM-101 is no longer viable for me, I am definitely going to try other routes for treatment. Giving up is for people that has met their conclusion with death. Quite frankly, I am no where near that stage yet. If you're not dead, you keep moving, that's the property of life.

I just want to make one thing clear, my objective isn't to dissuade anyone from going through with their own AM-101 treatments. I am just reporting my experiences in order to educate myself and perhaps others that goes through a similar situation. The lesson I am offering based on my experience...

@SteveToHeal To be honest, it wasn't as graceful as it seems, when I first got the phone call from Auris this morning with their blurred explanation for why I was exactly disqualified I was quite frantic, because the doctor made me seem to them like some kind of disingenuous human since I...

@Rube Due to the complexity of your issue perhaps you should speak with those ENT doctors and get some opinions from them after your MRI, you have two weeks from now to make your decision so that should be enough time to get everything checked before you make the decision to go ahead with the...

@attheedgeofscience Auris is not at fault here in any way, they're just working off the information this doctor is providing them. It is only natural for them to take the word of their study doctor with the utmost certainty. The only thing I regret was not recording the initial conversation at...

Thank you for the feedback; however, the conversation we had only raises more questions. Now I am being told the reason was not solely due to the driving issue apparently, so now I am wondering what were the other issues for the denial of treatment? Although you do not know conclusively, your...

I do agree with your sentiment; however, I am willing to receive anything I can get at this point, old doc or new...I'd also like to believe a doctor wouldn't intentionally harm their patient over some exchange of points, maybe that's just me though.

Thanks, I appreciate your feedback, also I have mentioned in a post a few pages back that this doctor is the only doctor in the entire state of Colorado offering this particular study treatment at the Colorado ENT & Allergy center. Perhaps I will put more details on here if things don't go the...

@earsnothappy Unfortunately the research coordinator at this particular hospital worked closely alongside this doctor that was supposed to give me the treatment for many years. I understand the position she is in, she didn't want to tarnish her professional relationship with the head doctor of...

Thanks for the encouragement, I'm just shocked because the last time we spoke at the preliminary exam he made it seem like the whole "you shouldn't drive" thing was a mere recommendation and not a requirement. I even told him, I probably won't have a driver with me, and he was nonchalant about...

Unfortunately I was rejected at the last minute, this incompetent doctor asked me at the last moment if I came with somebody to drive me home, and I said no, because the agreement was I will be staying at the hotel and using cab rides for the time being...so he said, "I'm not giving you any...

I'm currently studying psych as an undergraduate, like any other pyschoactive substance Benzodiazepene needs to be carefully weighed with the benefit/risk factor. Perhaps the patient and the doctor reached a conclusion that the benefits of taking this CNS depressant far outweighs the risk of...

Benzodiazapene should make you indifferent to your tinnitus as well as most other things in your life. It will surely take the edge off the frustration and anxiety that tinnitus may bring on; however, this drug in itself wouldn't "cure" tinnitus. I think it would psychologically "mask" your...

@earsnothappy Quite frankly my ENT isn't giving me any more information than what I already know. In fact it seems like I know more than he does when it comes to AM-101 since I've been reading anecdotal reports from users like yourself on this forum. I am also on this trip alone since I am a...

@Christian78 You have no reason to apologize for anything. Everybody on this forum should maintain a level of sympathy since we are all going through the same struggle of tinnitus. Only a psychopathic antisocial asshole would disregard the feelings of frustration, hopelessness, desperation, and...

@aarondowns22 I'm 90% sure that I will, it is scheduled for Wednesday. Now I'm just hoping that I get the real thing and not the placebo since I'm still only 5 weeks into tinnitus like you are. It would be a shame for anyone that gets the placebo while they're still well within the acute...

@Eric Fridley Unfortunately Aut00063 will take years for it to be obtainable for most of us. Have you considered partaking in the AM-101 trials? If you've already exhausted all the other basic treatments to no avail, AM-101 might be something to at least consider. Personally, if I go through...

@Rube I would definitely schedule an appointment for the preliminary exam so they can help you identify your current severity of tinnitus from a medical aspect, and your degree of hearing loss, if any. They will also clarify any questions you might have, although they won't really tell you any...