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  1. NGC891

    Retigabine (Trobalt, Potiga) — General Discussion

    Here is a good example of my eye floater... since my Trobalt Trial. You have to moove your mouse to see them. http://www.anthonyantonellis.com/floaters/ What type are your eye floatere after Trobalt?
  2. NGC891

    Disco with Earplugs a Problem?

    Hi, -15db isn't enough! With my 15th esperiency... I will sat... It's best to avoid loud place if you have already tinnitus... You can do a test at home. If when you listen loud music, tinnitus is higher... be carrefull! I think the best ear plug when put correctly are these: Ear Classic super...
  3. NGC891

    Flying vs. Long-Distance Driving

    Hi, I am agree with @Ecip, the jet plane frequencies (white noise) are easier to protect with earplug than car frequencies (low).
  4. NGC891

    Retigabine (Trobalt, Potiga) — General Discussion

    Hello, I do not write much about the forum because of time. I am dad for 4 months and I rehabilitates a ruined house ... I read a lot of comments lately and wanted to give my views on the use of Trobalt.I have tinnitus about 9/10 almost unbearable and reagents tinnitus after several acoustic...
  5. NGC891

    Brivaracetam — KV3.1 Modulator

    From http://www.jpp.krakow.pl/journal/archive/12_09/pdf/37_12_09_article.pdf Levitiracetam decrease SV2A excitation but also seems to act on KV3.1... "Levetiracetam (LEV) is an S-enantiomer pyrrolidone derivative with established antiepileptic efficacy in generalizedepilepsy and partial...
  6. NGC891

    Gabapentin (Neurontin)

    I have tried Gabapentin at 1200 mg per day ( 2 x 600mg) during one month. No significant change on tinnitus
  7. NGC891

    Autifony Therapeutics Phase II Study for AUT00063, for the Treatment of Hearing Loss and Tinnitus

    For those who wish to know more about the molecule ... AUT00063 patent... http://www.google.com/patents/US8722695
  8. NGC891

    Levetiracetam (Keppra) — Another Possible Potassium Channel Modulator?

    Thank you for this answer @Viking This is a remarkable improvement for you and I'm happy for you. Maybe i should begin a Keppra trial after Trobalt!
  9. NGC891

    Levetiracetam (Keppra) — Another Possible Potassium Channel Modulator?

    @Viking thanks for the updates, Does the effect you described applies only to the subjective perception of noise levels, or can you tell us if you feel that your tinnitus since your Keppra treatment less reactive to external sounds? It's really encouraging your results and I wish you more...
  10. NGC891

    Retigabine (Trobalt, Potiga) — General Discussion

    Be carrefull with cheaper generics from India... http://www.madinamerica.com/2015/01/european-medicines-agency-calls-suspending-four-common-psychiatric-drugs/
  11. NGC891

    Autifony Therapeutics Phase II Study for AUT00063, for the Treatment of Hearing Loss and Tinnitus

    Congratulations for having the chance to access to this trial!!! You say your T varies widely. Is there before the treatment? Can you tell us the dosage of taking the tablets? At what times of the day? On an empty stomach? Finally, can you tell us specify as the origin of your tinnitus and...
  12. NGC891

    Retigabine (Trobalt, Potiga) — User Experiences

    Progress Report Progress Report Date: Jan 12, 2015 Current Retigabine Dosage: 150+150+150 per day/ Weigh 69kg / Start Trobalt 9 weeks ago. I'm alternate between 150 mg TID and 200mg because the effects on Tinnitus fade away Current Side Effects: + Better earing - Hyperacusis was very high...
  13. NGC891

    Levetiracetam (Keppra) — Another Possible Potassium Channel Modulator?

    I am agree with you!!! @benryu What do you think of these previous thread? Levetiracetam (Keppra) — Another Possible Potassium Channel Modulator? I am so happy for you @Viking . My tinnitus behaved exactly as you describe before starting the Trobalt. With @Zimichael, I discovered that this...
  14. NGC891

    Levetiracetam (Keppra) — Another Possible Potassium Channel Modulator?

    Dear @Zimichael, The next documents refers to antiepileptic drugs. The following theory considers the hypothesis that the mechanism associated with tinnitus is similar to seizures. 1) From: The mechanism of action of retigabine (ezogabine), a first-in-class K+ channel opener for the treatment...
  15. NGC891

    Retigabine (Trobalt, Potiga) — General Discussion

    This is an average over the last 8 days.
  16. NGC891

    Retigabine (Trobalt, Potiga) — General Discussion

    I only report my impressions that have evolved since I started taking Trobalt. At the beginning of treatment, I felt with 150mg TID that the sounds were more muffled. I then continued and increasing to 200mg TID. It was worse for my tinnitus. So I decided to go down to 150mg TID that gave me...
  17. NGC891

    Retigabine (Trobalt, Potiga) — User Experiences

    Progress Report Progress Report Date: Dec 23, 2014 Current Retigabine Dosage: 200+200+200 per day/ Weigh 69kg / Start Trobalt 6 weeks ago. After 12 days at 200mg TID, I'm back down to 150 mg TID for 5 days because the effects seemed to fade Then I went up to 200mg TID for 10 days. Current...
  18. NGC891

    Retigabine (Trobalt, Potiga) — General Discussion

    Trobalt certainly has a lot of side effects that are probably insufficiently highlighted by the laboratory .... It's still surprising despite the very positive results of clinical trials before. Visual examination is a necessity but it appears that a urinalysis also necessary. Is it done other...
  19. NGC891

    Retigabine (Trobalt, Potiga) — User Experiences

    Progress Report Progress Report Date: Dec 1, 2014 Current Retigabine Dosage: 200+200+200 per day/ Weigh 69kg / Start Trobalt 3 weeks ago Current Side Effects: - When I went from 150 to 200, I have not seen any increase in side effects other than the sledgehammer sensation that occurs...
  20. NGC891

    Retigabine (Trobalt, Potiga) — General Discussion

    I am of the same opinion as @Juan Carlos. Evening dose can reduce tinnitus that increase often throughout the day. . For several nights I hardly sleep because of coughing and my tinnitus returned to their level before I started treatment. In the great evils great remedies! That night I slept...
  21. NGC891

    Retigabine (Trobalt, Potiga) — General Discussion

    @rtwombly, @locoyeti, I started as @rtwombly because my neurologist with little experience on the Trobalt preferred to give me a lower dose to start (150 the first two weeks and 300mg / day the next week). This allows him to verify that you tolerate the drug. I was also worried about not being...
  22. NGC891

    Retigabine (Trobalt, Potiga) — User Experiences

    Progress Report Progress Report Date: Nov 23, 2014 Current Retigabine Dosage: 100+100+100 Current Side Effects: Slight dizziness since I was in total 300mg per day Headaches for several days, but now I have none. Very good apetite. I sleep well and I have some difficulty getting out of bed...
  23. NGC891

    Feedback Info: Cause of Tinnitus

    thank you very much @Markku for this :thankyousign:
  24. NGC891

    Autifony Therapeutics Phase II Study for AUT00063, for the Treatment of Hearing Loss and Tinnitus

    It's a very good news for UK citizen. I can't participate to this trial... :( because: - I am not UK citizen! - My hearing is not bad enough (less than 20 dB loss) on my audiogram. And yet I hear really worse than before my last NIHL. If this inclusion criteria number 4 is respected, I do not...
  25. NGC891

    Retigabine (Trobalt, Potiga) — User Experiences

    Progress Report Progress Report Date: Nov 14, 2014 Current Retigabine Dosage: 50+50+50 Current Side Effects: Current Tinnitus Severity: 9 out of 10 Changes in Tinnitus: After few days at 150mg per day: Today, the hearing activity appears slowed. Sensation of tinnitus less present but...
  26. NGC891

    Retigabine (Trobalt, Potiga) — General Discussion

    Yes! Here in France, these 3 boxes cost 23,93€
  27. NGC891

    Retigabine (Trobalt, Potiga) — General Discussion

    hello, @Mpt This is very encouraging to hear that your T is not here! :rolleyes: I'm very happy for you. Could you remember if you have definitively stop Trobalt today? since how many times? Could you confirm to us that your T have continued to decrease after cessation of Trobalt ? Can you tell...
  28. NGC891

    Retigabine (Trobalt, Potiga) — General Discussion

    Hi, Thank you Zimichael for your answer. I have add tinnitus detail in my profile. If you want another information, you can ask me. Below, somes pictures of Trobalt box that I have bought in a Pharmacy (France).
  29. NGC891

    2014/11/12: Left ear: hissing 11kHz Right ear: hissing 11kHz + low pulsatile 2,8kHz

    2014/11/12: Left ear: hissing 11kHz Right ear: hissing 11kHz + low pulsatile 2,8kHz
  30. NGC891

    Retigabine (Trobalt, Potiga) — User Experiences

    New User Information Gender: Male Age: 35 How Long Have You Suffered From Tinnitus? (Date of Onset): Nov 11, 1998 How Did You Get Tinnitus?: Acoustic Trauma Explain How You Got Tinnitus: Is Your Tinnitus in Which of the Following?: Both Ears, Head What Kind of Tinnitus Do You...
  31. NGC891

    Retigabine (Trobalt, Potiga) — General Discussion

    Hi, I have found this. It's could be important to take the pill at the good time for having the best absorption. It also could reduce side effects? "...Pharmacokinetics Retigabine when orally administered is rapidly absorbed and has a bioavailability of 60%. Food delays its absorption by 2...
  32. NGC891

    Retigabine (Trobalt, Potiga) — General Discussion

    @Christian78 Hello Christian, Thank you for your return because currently you are the only one on the forum to describe all that you feel with Trobalt. You are very courageous and I hope that your side-effects will be arranged as fast as possible . I hope your tinnitus will remain slower than...
  33. NGC891

    Hi, I'm 24 and New to Tinnitus. Would Really Appreciate Some Help or Advice Please.

    List of drugs could make(or increase?) tinnitus: http://hearinglosshelp.com/articles/pdf/TinnitusDrugList2013.pdf
  34. NGC891

    Retigabine (Trobalt, Potiga) — General Discussion

    @ Christian78 We all support you . I hope you will get better quickly. We all have ups and downs. It could be an interaction between Trobalt and Diazepam you take. How long you take Diazepam an trobalt at the same time? 1) Diazepam appears to be part of the drug could generate tinnitus (see p11...
  35. NGC891

    Autifony Therapeutics Phase II Study for AUT00063, for the Treatment of Hearing Loss and Tinnitus

    If it's possible, it's should be a very good point. (y) Thanks to the administrators for your work. :thankyousign:
  36. NGC891

    Retigabine (Trobalt, Potiga) — General Discussion

    Hi everyone, @SteveToHeal: thank you for these questions! Here are some questions I ask myself on Trobalt to complet STH. 8. I wonder if and how Trobalt can induce a change in the long therm KV7 channel function by restoring a normal level of activity. @Mpt Informed us of its effectiveness...
  37. NGC891

    Tinnitus Loudness When Listening To Other Things

    This is the first time I hear a audiologist mention that. Yet it is so true in my case! I was told just the opposite there 18 years ... From experience, the noise immediately strengthens the intensity of my T (definition of hyperacusis?) The use of earplugs in low noise environments allows me...
  38. NGC891

    Efficacy of Amitriptyline in the Treatment of Subjective Tinnitus

    Hi, I've been also on a low dose (25mg) for the last month. It didn't improve my T but it helps me to sleep. Ma T was caused by acoustic trauma.