A Study on the Effect of Cilostazol in Patients With Chronic Tinnitus (CITI-ESR)

[Tinnitus Talk]

Tinnitus Talk submitted a new resource:

A Study on the Effect of Cilostazol in Patients With Chronic Tinnitus (CITI-ESR) (version 1.0) - To validate whether administration of cilostazol can improve tinnitus.

1. Overview of tinnitus Tinnitus is a noisy sound which is perceived without any external sound source. According to the survey of the US, 10-20% of adult have the symptom of tinnitus and 3-5% of tinnitus patients have severe discomfort of daily life. Severe tinnitus can result in psychiatric problems such as depression and anxiety disorders. Enhancement of environmental sound, hearing aids, sound generators, cognitive therapy, transcranial magnetic therapy, and drug therapy have been...

Read more about this resource...

 

[beeeep]

I guess the study finished, at least there's a matching publication:

https://www.ncbi.nlm.nih.gov/pubmed/27716604

RESULTS:
The improvement range in the VAS score was significantly greater in the cilostazol group than in the placebo group after 4 weeks' administration of cilostazol. The SF-36 subscales also showed improvement in quality of life in the physical component summary subscale, the aggregate subscale of the physical category. There were no significant improvements in the cilostazol group compared to the placebo group in the THI subscales and tinnitus characteristics of pitch and loudness matching values. Various degrees of headaches were experienced by 68% of patients in the cilostazol group.

 

[Candy]

Is this good news? Anyone taking these meds?

 

[Neilpk]

This looks really promising but it's showing a completion date in 2013.

What's the latest on this. Anyone have any insight?

 

[The Red Viper]

Improved quality of life but no improvement in THI or frequency matching? Plus headaches in the drug group? Sounds like a huge failure to me. Also, if the study was completed in 2013 and the results are just out now, you know that it was likely a failure. They were probably pressured to release the results after waiting so long.

 

[Neilpk]

Optimist

 

[Oli]

Realistic

 

[Neilpk]

Yep... you are probably right.

 

[ruben ruiz]

Hopeful...

 

[ruben ruiz]

If it works where is it?

 

[Frédéric]

Just to recall the reference of the clinical trial since it is not mentioned in the matching publication:
https://clinicaltrials.gov/ct2/show/NCT01378650
Status: this study has been completed.