omeprazole and all the other acid reflux medications that fall under the catagory of "proton pump inhibitors" have a nearly identical method of action...they stop the cells in the stomach from producing acid (parietal cells) by halting the ADP_ATP (adenosine tri phosphate) energy reaction
ATP is whats behind much of what ever happens in the body...the power supply...its what moves muscles for example
many years ago johns hopkins univesity performed some startling experiments
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"Brain scientists at Johns Hopkins have discovered how cells in the developing ear make their own noise, long before the ear is able to detect sound around them. The finding, reported in this week's
Nature, helps to explain how the developing auditory system generates brain activity in the absence of sound. It also may explain why people sometimes experience
tinnitus and hear sounds that seem to come from nowhere.
The research team made their discovery while studying the properties of non-nerve cells in the ears of young rats. These so-called support cells were thought to be silent bystanders not directly involved in nerve communication. However, to the researchers' surprise, these cells showed robust electrical activity, similar to nerve cells. Further, this activity occurred spontaneously, without sound or any external stimulus.
"It's long been thought that nerve cells that connect auditory organs to the brain need to experience sound or other nerve activity to find their way to the part of the brain responsible for processing sound," says the study's lead author, Dwight Bergles, Ph.D., an associate professor of
neuroscience at Hopkins. "So when we saw that these supporting cells could generate their own electrical activity, we suspected they might somehow be involved in triggering the activity required for proper nerve wiring."
To figure out how these cells were generating electrical pulses, Bergles' team suspected that a chemical might be involved; so they applied a number of different candidate drugs and chemicals to the developing cochlea -- the small, hollow and liquid-filled chamber in the inner ear that converts sound waves to electrical signals -- hoping to block the mystery trigger. The few drugs that altered the electrical output all disabled ATP (adenosine triphosphate), a chemical most often used as a cell's energy currency but also, as in this case, as a signal to communicate with other cells.
According to Bergles, a breakthrough came when it was discovered that ATP also caused the supporting cells to change their shape. By simply videotaping the developing cochlea, the team was able to monitor where and when ATP was released. After studying these movies, they found that ATP was being released near hair cells, the cells that are responsible for transferring sound information to auditory nerves. It was known that hair cells have receptors for ATP, so they might also be affected by the ATP released from the supporting cells. Indeed, the team found that hair cells also showed spontaneous electrical activity, which occurred at the same time as the responses in neighboring support cells and was blocked by drugs that block ATP receptors.
In a domino-like effect, ATP then signals the hair cells to release another chemical, glutamate, which then activates the nerve cells that project into the brain. "It is as if ATP substitutes for sound when the ear is still immature and physically incapable of detecting sound," says Bergles, adding that "the cells we have been studying seem to be warming up the machinery that will later be used to transmit sound signals to the brain."
http://www.medicalnewstoday.com/releases/87377.php
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i found the ATP glutamate connection fascinating, when i first read this article, and it was one of the inputs to my thinking that shifted me from a GABA to a glutamate solution
whats amazing about the PPIs (proton pump inhibitors used for curbing stomach acid) is that as one withdraws from taking PPIs or as the body gets "used" to PPIs, like lots of other drugs you gotta take more to get the same effect...AND when you stop, if abruptly, things go into over drive
so one could see how the use of PPIs might b related to tinnitus
plus
did you read the part above about how as the ear is developing the nerves produce ATP next to the developing hair cells and cause the sence of sound in the embrionic ear, even tho there is no sound...hmmmm seems similar to tinnitus where hair cells have been wiped out to me...maybe
again as erik and others have pointed out, how do we get the treatment to the problem spot and not affect the entire brain nor the entire body
one wonders if insted of pumping AM-101 into the ear, if instead a very small dose of omeprazole trickled thru the round window might do the trick
very interesting stuff
i continue to think the fix is to be had in the cochlea which is not to say that lots of people dont use the filtering and processing centers in the auditory cortex or dorsal cochlear nucleus or other more central parts of the brain (limbic system etc) to wed out or mute tinnitus..no im not saying that...yes there may be some brain entered adjustments or remediation that can alleviate the sense of tinnitus
but i still believe the part that is really broken and is subject to repair in the cochlea and specifically the hair cells an th organ of corti
of course im way out on a limb here...not a doctor nor a biologist or a scientists so take what i say with huge grains of salt...im a rank amateur at best
best of good luck to all
mt
its all so complicated it hurts my head just to think about it so maybe the just learn to ignore it and habituate is still the best medicine...i... just... dont.... know
i guess my compulsivity drives my continued search or greater understanding and an effective treatment