I wanted to weigh in on the CBD Oil. It has become legal in Maine and is all the rage being sold in many luring forms. In my research of it, it has been tested as an anticonvulsive and for psychotic behavior. Other than that, no.
There's some reports on cannabis receptors that were named according to the neurons and g proteins it affects that were mostly studied in response to cannabis use as an anti-vomiting agent for chemo therapy. Oddly, too much cannabis use can cause vomiting and research shows that capsaicin will as a neurotoxin to the responsible Substance P, help cure the problem.
CBD Oil won't exactly lead to this problem although it is not because the oil lacks THC.
However, the one BIG thing this little diversion lead to was identifying that it is well known by the scientific community that it affects as in induces production of the cytochrome enzyme CYP3A4. This specific enzyme is the one that grapefruit inhibits which is why grapefruit is great for cancer. And, it is because of this enzyme certain medications stress not to eat grapefruit. This enzyme, CYP3A4 is also responsible for reducing testosterone and involved in prostate cancer. It is elevated in breast cancer. The fetus does not have this enzyme until after several months of life and exposure to it is not good. CYP3A4 is targeted to increase in chemical castration drugs used on heinous criminals and can lead to sterility by increasing the enzyme.
I encourage all the CBD Oil enthusiasts to research this. You can read about CYP3A4 on Wikipedia - there's a page and about half way down there's a chart that shows drugs that induce or inhibit and drugs that induce the enzyme.There's articles you can access on PubMed (one is An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies Kerstin Iffland, and Franjo Grotenhermen) that doesn't condemn CBD Oil nor specify that it increases CYP3A4 enzymes. But, because CYP3A4 is part of a group of cytochromes of the collective family P450, this statement has particular implications: "Studies in mice have shown that CBD inactivates cytochrome P450 isozymes in the short term, but can induce them after repeated administration." This could be interpreted that at first, you might notice benefits but long term use is going to increase this family of enzymes that includes CYP3A4 that causes breast cancer, decreases testosterone, plays a key role in prostate cancer and is purposely targeted to increase in drugs that are designed to cause chemical castration.
Having never tried CBD oil myself, I became suspicious that suddenly we were allowed to have it. Or maybe it was the bright candy gummy bear forms being sold like on the store counters. CBD oil was legalized and also cannabis here. The latter was by referendum. The state also just legalized right to "death with dignity" if you have been deemed to have 6 months or less to live by a doctor - they will prescribe drugs so the person can commit suicide. The State expanded legalized abortion by allowing all doctors, nurses, physician's assistants and the like in any medical office to perform them, which will likely reduce birthrates. And, vaccination was made mandatory for all, as they decided to include certain religious and conscientious objections that few knew about. The population in my state is the oldest in the nation and the birth rate the lowest. Despite this, with all kinds of vacated homes from the elderly dying off and going to assisted living, there is the worst housing shortage in the history of the state because outside investors, and I do mean outsiders as in foreigner are buying the property and sitting on it.
None of these things alone seem a huge issue but together -- and with the legalization of a drug - CBD oil that will cause cancer likely to be used by childbearing and middle age folks having pain... and tinnitus, you gotta wonder what is going on.
Why on earth would the FDA allow CBD oil on the market? Recently there were comments that it was approved without testing it properly and needs to undergo further study but it was not pulled like certain vitamins and herbs have been. FDA had stated CBD was GRAS - generally recognized as safe. But, if you understand the biology of how it works... I think you'd be better off chewing on poppies. I am sure if a person has chronic untreated pain it is a better alternative to prescription pain killers or street drugs.
But, considering, I personally would not want to put this in my body, not in my ears and not for tinnitus unless I was absolutely positive I was at my bitter end and could accept the consequences. It is a slyly marketed drug that will in the future show its ugly head.
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