Alzheimer's Drug (Aducanumab) Study Gives 'Tantalising' Results

[Candy]

http://www.bbc.co.uk/news/health-37222863

This is such good news...science is always making progress. Tinnitus won't be too far behind hopefully.

 

[undecided]

I imagine someone on some Alzheimer's forum reads this, gets super excited, parties, goes to bed, same shit in the morning can't remember anything about any drug, goes back to the forum, reads about the drug, gets super excit....

Sorry, bad joke, worth posting though.

 

[Sebastians]

I vaguely remember reading about this stuff ;-)
Maybe if i get alzheimer's i forget about having T!

 

[Vinnitus]

I vaguely remember reading about this stuff ;-)
Maybe if i get alzheimer's i forget about having T!

http://www.webmd.com/healthy-aging/news/20110214/hearing-loss-may-be-linked-to-alzheimers

You might be on to something!

I often see talk about habituation here where people don't notice their tinnitus for months or years on end. I guess it's explained now; it's early onset Alzheimer's. They just forgot they have it (among other things).

I'm not so sure I want to habituate now...

 

[Kane Moffat]

I imagine someone on some Alzheimer's forum reads this, gets super excited, parties, goes to bed, same shit in the morning can't remember anything about any drug, goes back to the forum, reads about the drug, gets super excit....

Sorry, bad joke, worth posting though.

Memory problems are not really that funny to be honest, if you have some kindof hearing loss you know your memory will eventually be effected? It wont be funny then.

 

[undecided]

Memory problems are not really that funny to be honest, if you have some kindof hearing loss you know your memory will eventually be effected? It wont be funny then.

I wrote a small disclaimer in the end for the sensitive ones.
Sorry you were, uh, offended.

 

[Vinnitus]

Going from here and the hypothesized link between hearing loss and Alzheimer's development

• http://neurosciencenews.com/alzheimers-hyperactive-neurons-3416/
• http://www.webmd.com/healthy-aging/news/20110214/hearing-loss-may-be-linked-to-alzheimers
  
• http://www.hopkinsmedicine.org/news...loss_linked_to_accelerated_brain_tissue_loss_

It would be interesting to see the trend regarding prevalence through the ages. As far as I know, the Alzheimer prevalence is steadily increasing.

Life expectancy has increased dramatically over the past century across the globe [1]. This salutary trend unfortunately also has a negative aspect in that common chronic diseases of older people are becoming much more prevalent. The number of people affected by Alzheimer's disease (AD) was 26.6 million worldwide in 2006, and it was estimated that $156 billion is spent annually to care for dementia patients worldwide [2]. By 2050, the prevalence is expected to quadruple, so that 1 in 85 persons will be living with the disease [3], and 43.0% of them are expected to need a high level of care (e.g., a nursing home).

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026476/

Our society has become increasingly noisier the last few centuries and people on average reach a higher age, meaning they accumulate more hearing loss throughout their lifetime. Maybe this could (partly) explain the increase in Alzheimer's prevalence as a cause of death when it is indeed linked to hearing loss.

Maybe Tinnitus in turn is some kind of chronic brain inflammation which causes our neurons to become hyperactive (inflammatory reaction) leading to earlier cell death. Cell death in turn releases free-radicals which attack other healthy cells (upon which they become hyper-excited) and may cause an ongoing chain reaction which might last for decades. This might potentially explain the worsening of Tinnitus as the inflammatory response spreads in time.

We know noise-exposure leads to cell damage or death in the inner ear, upon which a free-radical (glutamate) is released. Maybe that's where it all starts...

It's just me speculating of course, but it kind of makes sense to me.