AM-101 Clinical Trial — Participants Updates and Discussion

[Elgringo32]

When I look at the figures in the presentation, in overall, the placebo group shows better improvement that in AM101 group....LOL
How can they continue this trial knowing that many people have been aggravated (and this seems to be AM101 related not the procedure) ?

 

[erik]

When I look at the figures in the presentation, in overall, the placebo group shows better improvement that in AM101 group....LOL
How can they continue this trial knowing that many people have been aggravated (and this seems to be AM101 related not the procedure) ?

http://www.fiercebiotech.com/biotec...l-re-jigs-new-phiii-for-tinnitus-med-keyzilen

 

[Candy]

Anyone signing up for the next trial in Europe?

 

[Hopeful1]

No one should do it....it does not work

 

[Alue]

No one should do it....it does not work

It seems it helps a small subset of people. My guess is the window of opportunity is very short also. In mice it was 2 days. Well no one from the trial got it before at least two to three weeks had passed and most people got it a month or two after onset.

I was wondering this the whole time I was in the trial, but I get the feeling tinnitus becomes centralized or chronic in a matter of days to weeks not months.

 

[Candy]

Mine has felt like it does now pretty quickly, wouldn't be surprised if it was a couple of days too. Did you get any benefit or negative reaction?

 

[Elgringo32]

AM-101 may help people with Otitis media only (according to their figure it seems that it is the most significant) . For traumatic, in overall, it does not help and it is worse.
For severe / extreme tinnitus group : does it include people from otitis media group which have severe/extreme T ?
I have some doubt regarding this minor improvement (4 points more) compared to the placebo.

 

[Ricardo1991]

Honestly, I think that's still some great news that at least someone somewhere is working to help us.

 

[Ian Mac]

It's not for us but they are helping that special subgroup

 

[ruben ruiz]

They are trying to make a buck...

 

[Foncky]

The positive thing is that it may allow Auris to find money to go on and create better treatments. If AM-101 is a total failure, I can only imagine it will compromise the company's short-term future.

 

[gotyoubynuts]

AURIS MEDICAL, LISTEN WHAT I HAVE TO SAY

AM 101 CAN work if you administer it to patients within 24 - 72 hours after they notice tinnitus!! TEST THAT HYPOTHESIS!!

 

[Vinnitus]

I was wondering this the whole time I was in the trial, but I get the feeling tinnitus becomes centralized or chronic in a matter of days to weeks not months.

But then how would one explain the various cases where Tinnitus leaves in the course of a few months or even years?

I agree on the short window of time to act on activity in the inner ear, hence most currently available ear-targeted treatments are only effective during the first few hours to days (steroids, Vitamin ACE+Mg supplementation, perhaps AM-101 etc.). I'm holding out hope though that "hidden" hearing loss (or "synaptic" hearing loss) has something to do with Tinnitus generation. Liberman mentioned that the opportunity to reverse synaptic hearing loss might possibly have a window of "months to years". Perhaps an ear-treatment that targets these synapses (like neurotrophins or something else) might still be able to do something after the initial short time window has passed or where this treatment does not work.

 

[Candy]

Would you participate in the trial @Vinnitus given that they are recruiting more people? Thinking about it, taking on board the negative experiences.

 

[Alue]

They are trying to make a buck...

No shit. I mean they spend millions in research and clinical trials and you're telling me they hope to recoup some of that investment? Somebody stop the press.

 

[Pleasure_Paulie]

No shit. I mean they spend millions in research and clinical trials and you're telling me they hope to recoup some of that investment? Somebody stop the press.

The normal cost of R&D for a new compound with the big pharma companies is often into the billions of dollars and normally over 10 years to get to the market... So yes, I agree Pharma companies are businesses just like all the others out there.. They exist for profit.

 

[Ian Mac]

And pharma can't fix your ears! Never gonna happen. Pharma is not a cure. If they ever found inhibiting something stopped T I guarantee the side effects would be so appalling you would never take the pill. So in the interest of our sanity please just abandon all hope in Pharma, you'll thank yourself later.

 

[Kazue]

The last 2 response above me are true. Sorry to say it but the pharma is there to prevent your complaint, but cause more problems so you can come back for even more medicine. For example, I usually take Advil for headaches. I took the maximum dosage and here I am with T. So I'm over scrambling for a cure for this ringing all because of some stupid pills.

 

[Pleasure_Paulie]

And pharma can't fix your ears! Never gonna happen. Pharma is not a cure. If they ever found inhibiting something stopped T I guarantee the side effects would be so appalling you would never take the pill. So in the interest of our sanity please just abandon all hope in Pharma, you'll thank yourself later.

Pharma is probably our best bet for an efficacious Tinnitus treatment into the future The partnership with Allergen is an example of this.
http://www.bizjournals.com/pittsbur...inks-research-partnership-with-drugmaker.html

Please don't spread misinformation as people should have hope. Research in Otology is already starting to spread with "hearing loss" targeted as a hugely profitable and untapped market. This is all many years away, but there a reason to have hope.

PS. Not all drugs have a side effect profile that of Trobalt

 

[Ian Mac]

No chance. Need to fix the damage not mask the tinnitus with a drug. The body won't allow it. You can trick the body for a while but in it's never ending quest for homeostasis the drug has tolerance and side effects, you can trick it, You can but in the end you get tricked worse!

 

[Pleasure_Paulie]

No chance. Need to fix the damage not mask the tinnitus with a drug. The body won't allow it. You can trick the body for a while but in it's never ending quest for homeostasis the drug has tolerance and side effects, you can trick it, You can but in the end you get tricked worse!

I'm not going to argue with you, but I don't think you understand how medications CAN work Pharmacology oneday will be able to fix the damage through gene therapy as regenerative medicines moves forward. An example is Otonomy's OTO-4xx project which is currently under development which aims to help the body restore afferent input to hair cells.

 

[Ricardo1991]

AURIS MEDICAL, LISTEN WHAT I HAVE TO SAY

AM 101 CAN work if you administer it to patients within 24 - 72 hours after they notice tinnitus!! TEST THAT HYPOTHESIS!!

Well, that would leave all of us hopeless then

 

[Pleasure_Paulie]

Well, that would leave all of us hopeless then

Don't feel hopeless. AM101 was always in development after onset of tinnitus. All research is important as we get closer

 

[Leon909]

Auris Medical published a new patent for tinnitus... not sure if this was posted before. I haven't read it yet. Maybe someone wants to have a go at it. Cheers!

https://www.google.com/patents/US20160271098

 

[Pleasure_Paulie]

Auris Medical published a new patent for tinnitus... not sure if this was posted before. I haven't read it yet. Maybe someone wants to have a go at it. Cheers!

https://www.google.com/patents/US20160271098

It for treatment of tinnitus using compound modulating chloride co-transporter NKCC1

 

[Ian Mac]

Ge

I'm not going to argue with you, but I don't think you understand how medications CAN work Pharmacology oneday will be able to fix the damage through gene therapy as regenerative medicines moves forward. An example is Otonomy's OTO-4xx project which is currently under development which aims to help the body restore afferent input to hair cells.

Gene therapy isn't Pharma. Yes gene therapy is our best chance, not Pharma I don't think you understand what Pharma is.

 

[Codaz]

Statements like this are absurd. This isn't how capitalism works. The people who make the breakthrough of solving tinnitus will be rich beyond their wildest dreams.

The reading glasses industry wasn't able to suppress lasik surgery. Don't be an idiot.

Lasik is far from safe. Yes there are wild stories about failure but also a lot has to be done in order to be super safe. Since 10 years the eye laser industry has opted for all sorts of techniques. All of them with pro's and cons.

I hope the ear doc's will make this tech leap. But a lot needs to be done first. Might be 30 yrs away.

I don't agree that "thousands" of studies are coming for T. Maybe in 200 years but not in the next 5.

 

[Pleasure_Paulie]

Gene therapy isn't Pharma. Yes gene therapy is our best chance, not Pharma I don't think you understand what Pharma is.

I think you're just trolling now as gene therapy can be delivered via medicine (see CFG166 by Novartis) to help stimulate new growth of cells. Not to mention even Trobalt showed long term effects in some members here; perhaps reversing the Neuroplasticity changes of tinnitus onset.

Regardless please don't spread misinformation; especially when we have new members coming and going here regularly looking for some type of hope over this dreaded condition! I won't be continuing this futile discussion as the topic is clearly AM101 and pointless trolling does not benefit anybody.

 

[Ricardo1991]

Don't feel hopeless. AM101 was always in development after onset of tinnitus. All research is important as we get closer

Aw, thank you! that did make me feel better.

 

[Ian Mac]

I think you're just trolling now as gene therapy can be delivered via medicine (see CFG166 by Novartis) to help stimulate new growth of cells. Not to mention even Trobalt showed long term effects in some members here; perhaps reversing the Neuroplasticity changes of tinnitus onset.

Regardless please don't spread misinformation; especially when we have new members coming and going here regularly looking for some type of hope over this dreaded condition! I won't be continuing this futile discussion as the topic is clearly AM101 and pointless trolling does not benefit anybody.

Please don't spread misinformation. Pharma cant bring lasting relief, it has no chance, trobalt doesn't work it's being discontinued. Gene therapy isn't a pharmacuetical. Yes gene therapy could work I agree thank you.