AM-101 TACTT1 Results Released

[urtica]

Ahm..
Part of the contract is to protect my ears with plugs against loud noise.

I really can't avoid parties and pubs!! no way!! I thought when I protect
my ears properly I can do whatever I did before whitout much restictions. I got 38db earplugs and no party is louder than 100db
so I sould be fine.. At least that's what a doctor said to me. On the other hand after I've been at a club my T had a spike for 2 weeks.. What are your experiences?

 

[Stina]

Ahm..
Part of the contract is to protect my ears with plugs against loud noise.

I really can't avoid parties and pubs!! no way!! I thought when I protect
my ears properly I can do whatever I did before whitout much restictions. I got 38db earplugs and no party is louder than 100db
so I sould be fine.. At least that's what a doctor said to me. On the other hand after I've been at a club my T had a spike for 2 weeks.. What are your experiences?

I think it could interfere with the results of the study (since you said that previously it has had an effect). Thats why Im concerned. Otherwise of course its your life and you can do what you want. But for scientific plausibilty it would probably be better to be more cautious in order to get correct results. I suppose all of us want the drug to come out and stuff like that could mess with it. In addition even plugs are not a 100% guarantee- from what I read on this board sometimes people have T get louder permanently after a night at clubs or bars. Sorry thats just my opinion.

 

[nills]

You mean you don`t want to avoid parties and pubs, has nothing to do with can ... all to do with being a bit responsible for your life. How many people would like to be in your place and you just want to throw away the chance for a night of dancing and a morning of headaches ... It should be fine but than again it could go bad. Just be strong and sit tight. you can manage a couple of weeks without parties man. And than come back and tell us how silent it was sitting at home ... how peaceful it is without that wicked T.

 

[Grace]

I agree with them ^^ dont ruin the chance of yours gettin better by makin it worse when you actually have a chance of it getting better.. The drugs gonna take time and further damage who knows what effect will have.. No ones tellin you what you can and cant do but like they said alot of people would love to be in your place and just wait patiently for the drug to see if it works... After however long that takes then you can push it a lil more knowing you tried but still with protection

 

[Champ]

Yeah man, at least wait until you're done with the study.

 

[Mpt]

I know that Fish and the guy Rusty Shackleford from Reddit had significant volume decreases after am-101 treatment (if they did in fact get the drug)- my question is how often do you think people get significant volume decreases after having t for a few months --- say a volume reduction from the level after 3 months to the level after 6 months? - do you think ths happens 50% of the time, more, less?

 

[Johno]

I know that Fish and the guy Rusty Shackleford from Reddit had significant volume decreases after am-101 treatment (if they did in fact get the drug)- my question is how often do you think people get significant volume decreases after having t for a few months --- say a volume reduction from the level after 3 months to the level after 6 months? - do you think ths happens 50% of the time, more, less?

I personally do not believe in memorization of tinitus (cause it has no point in nature). If is true, that cochlea damage induced T is firing by glutamate inbalance and its excitotoxicity, and AM101 can calm this situation, its highly possible, that it can help even in chronic case.

I believe it can help, because this is only thing i can do. :/

 

[GMac14]

Yes, of course, but shot from pistol takes maybe 1/100 of second and healthy ears can withstand 110 Db for around 1minute before permanent damaging occurs With ear protection you should fire around 6000 shells to damage your hearing

Hard to believe IPods get to 115 db! I was absolutely shocked and appalled when I found out and felt very guilty for ever putting those damn earbuds in my ears.

 

[Stina]

I know that Fish and the guy Rusty Shackleford from Reddit had significant volume decreases after am-101 treatment (if they did in fact get the drug)- my question is how often do you think people get significant volume decreases after having t for a few months --- say a volume reduction from the level after 3 months to the level after 6 months? - do you think ths happens 50% of the time, more, less?

some docs say that it in 80% of the cases the T naturally reduces in a year. But I dont know if it specifies whther it is reduction through habituation (eg. it seems more quiet) or it actually becomes more quiet. Could be either way. Ive had it since mid Nov and I dnt think it has gone down, maybe only occasionally a little bit. But there is no real data about the reduction of volume, so Im just assuming.

 

[Mpt]

My question though is why would am-101 work gradually if that's the case exitoxicity and unregulation happen in a moment wouldn't glutamate receptor inhibition happen spontaneously if the drug were effective?

 

[Johno]

My question though is why would am-101 work gradually if that's the case exitoxicity and unregulation happen in a moment wouldn't glutamate receptor inhibition happen spontaneously if the drug were effective?

From wikipedia:

Microinjection of glutamic acid into neurons produces spontaneous depolarisations around one second apart, and this firing pattern is similar to what is known as paroxysmal depolarizing shift in epileptic attacks. This change in the resting membrane potential at seizure foci could cause spontaneous opening of voltage-activated calcium channels, leading to glutamic acid release and further depolarization.

- looks like it is some sort of chain reaction, that never stops. (it may stop spontaneously, but when? Luckers have concert or loud pub induced T few days and it disappears. We are unluckers. Probably genetic predisposition?)

Looks like Am101 can chemically stop this chain reaction.

 

[Stina]

From wikipedia:

Microinjection of glutamic acid into neurons produces spontaneous depolarisations around one second apart, and this firing pattern is similar to what is known as paroxysmal depolarizing shift in epileptic attacks. This change in the resting membrane potential at seizure foci could cause spontaneous opening of voltage-activated calcium channels, leading to glutamic acid release and further depolarization.

- looks like it is some sort of chain reaction, that never stops. (it may stop spontaneously, but when? Luckers have concert or loud pub induced T few days and it disappears. We are unluckers. Probably genetic predisposition?)

Looks like Am101 can chemically stop this chain reaction.

shouldnt tinnitus be progressive then if its a chain reaction?

 

[Grace]

Hard to believe IPods get to 115 db! I was absolutely shocked and appalled when I found out and felt very guilty for ever putting those damn earbuds in my ears.

Lol yeah i never EVER knew that either... Would say my ears are pretty damn strong cause i remember practically all my life from school to goin on long car trips havin my ipod on full blast and never had ringing ears from it.. But ya know it only took about 135 db blasting in my ear for 45 mins to get T but after two days practically went away almost But i am never ever blastin my ipod like that again.. Actually havent touched mine since T and i really dont want too those things are too scary now even if they are turned down low.. Not riskin it in my ear.. Our generation and our kids are in extreme risk with those things... I wouldnt doubt if everyone we know in 20 years has some form of T... :-/

 

[Johno]

shouldnt tinnitus be progressive then if its a chain reaction?

Good question Yes, it can be. Maybe. I read study about Finland soldiers, who received T from gunfire. After a year, 50 percent of them had T. After 10 years only 12% of them still had T. It was in 80s-90s. I dont know if they was(and how) treated. But i am not this case

 

[Mpt]

why would the effect be permanent.... Ketamine wears off

 

[Stina]

Good question Yes, it can be. Maybe. I read study about Finland soldiers, who received T from gunfire. After a year, 50 percent of them had T. After 10 years only 12% of them still had T. It was in 80s-90s. I dont know if they was(and how) treated. But i am not this case

I actually meant by progressive that it will get worse and worse in time if its a chain reaction

 

[Stina]

why would the effect be permanent.... Ketamine wears off

No one has said that it is permanent they are still in the trial phase.

 

[Mpt]

Johno... let me know if you have a link to that article, that would be interesting

 

[Mpt]

On the disclosure document I got from Auris medical regarding the trial it sys that it produces an irreversible diminishing of tinnitus.... irreversible seems permanent to me

 

[Stina]

On the disclosure document I got from Auris medical regarding the trial it sys that it produces an irreversible diminishing of tinnitus.... irreversible seems permanent to me

well probably ketamin does the job amd then wears off I suppose unless you are a doctor there is no way we can actuallu understand how it really works. needs to much background information.

 

[Johno]

I actually meant by progressive that it will get worse and worse in time if its a chain reaction

Aha Sorry, i dont understand question Ok. It can be better, but yes, unfortunately it can be worse. And i am scared. We are living in noisy world. I was today out, walking in streets of my town and - a lot of motorcycles without mufflers. A lot of cars with old rusty exhaust. A lot of workers, working on new constructions. My hands cover my ears permanently Our hearing is like wall. If it is healthy, you can put on it heavy weight. But if the wall bursts, much less weight can do more damage. Cumulative effect. Presbycus and noises, ototoxic drugs or food, our ears are in damaging mode permanently and this is fuel for chain reaction. We can say, glutamate chain reaction can calm down (like in atomic reactor), but we are giving new fuel to it.

- Even if is AM101 functional, this doesn't mean than we can't receive T again.

 

[pug]

Are trials for this currently running or soon to be running in the UK at all?

 

[Hudson]

Are trials for this currently running or soon to be running in the UK at all?

http://www.tinnitus-study.info/uk-home

Yes, they are.

 

[Johno]

Johno... let me know if you have a link to that article, that would be interesting

I read it somewhere in 2012, i try find it, but can not guarantee sucess.

 

[Brian32]

Something I meant to ask before but forgot, How big is the needle they use to inject the drug? Is it a small hypodermic needle or a larger one?

 

[Johno]

Johno... let me know if you have a link to that article, that would be interesting

I found it: http://www.ncbi.nlm.nih.gov/pubmed/12006740

 

[Hudson]

Something I meant to ask before but forgot, How big is the needle they use to inject the drug? Is it a small hypodermic needle or a larger one?

It is reportedly very small. The hole made for this procedure is much smaller than the holes made in someone's ear drum for tubes due to chronic ear infections, for example.

 

[GMac14]

Has anyone else had a hard time logging into the tinnitus-study.info website? Trying to look up the trial locations in Canada.

 

[Hudson]

Has anyone else had a hard time logging into the tinnitus-study.info website? Trying to look up the trial locations in Canada.

You can always email them auris-trials@medpace.com. They'll get back to you pretty quickly and inform you if there is a participating site near you.

 

[urtica]

You guys put me in a relly hard time lately. I'm really ditroyed the last days, because a lot of you guys advice to let down parties, concerts, bars, and clubs forever.
I've read all kinds of experiences, where even with plugs, concerts or clubs made T worse. And I think that's also what happened to me in january, where I've benn out on 4 days in a row. In mind i could do whatever I used to, just with plugs.. The end was a 2 weeks spike horror.
The point is: Organising parties and concerts and going to parties, bars and so are basicaly what my life is centered around. I live and work in a cultural center! Avoiding that all my life, would put my life upside down! Also this is where all my friends and social contacts meet. That put me in a real depression.

I don't understand why our ears are that sensitive, that even earplugs (37db) cant protect them. I'm thinking about having some molded ones done, just to try if they are better.

I'll have to find a way!! Anyway I'll not go to the party tonight, you cinvinced me. I'll wait more time and then little by little try to go into loud enviroments again. I'll have a dj-gig in two weeks, where i can adjust the volume knob. I have to go to that kind of venues again, otherwise my life is ruined.