The AM-101 is intratympanic because it's a localized glutamate blocker, but if the the AM-102 is targetting potassium channels, there is no reason it should be an injection, so most likely pills.
But again we are supposing a lot of stuff here
Let's wait for more info!
There is no reason for a drug company to only produce I.T. drugs. They will produce whatever works. I also think (hope) Auris have seen Autifony are onto something with potassium channel Kv modulators and trying to replicate their own "version" in the race to find a cure. Like what @benryu said, that AM102 could be just that.
There is no reason for a drug company to only produce I.T. drugs. They will produce whatever works. I also think (hope) Auris have seen Autifony are onto something with potassium channel Kv modulators and trying to replicate their own "version" in the race to find a cure. Like what @benryu said, that AM102 could be just that.
Speculation, I know but just maybe?
Maybe they have seen sufficient evidence in human "self-trial", just from looking at this forum (we know the Am101 thread has caught the attention of Auris already), that Retgabine @Mpt has worked, another potassium channel Kv modulators. Chances are, efforts from specific individuals here, have motivated AM102 and for it to go into pre-clinical trials. The guys here should get profit share if it works
Then again, providing the drug companies with any info that would speed up or point them in the direction, I am all for. Even if it is inspired by some very brave individuals on these forums.
They've been in contact with us. As a result, we also added the notification at the top of the AM-101 threads.
Yours is classified as acute.
Hi @benryu - it's the anti-hijacker here!! It's my pet hate so have moved the discussion here to its rightful place via the link below
Yes - they are testing with placebos. See the latest post (page 46) from @locoyeti . He has had some success. There are others too but you would have to scroll through all pages on this thread to see which ones. We need a wall of fame on the new site that Markhu and SteveH are busy with, to see who has had success and who hasn't.
Hi @benryu - it's the anti-hijacker here!! It's my pet hate so have moved the discussion here to its rightful place via the link below
https://www.tinnitustalk.com/threads/retigabine-trobalt-potiga.5074/page-27#post-60719
I refer to your link. Tx re the info on glutamate blocking and hair cell death. Ominous! I guess my question is ... Why do you think AM101 are trialing > 3 months in their TACTT3 study? If hair cell death has already occurred < 3 months. What do they hope to achieve > 3 months?
You said : "During the death process the excess of glutamate is being released but will go back to a normal level when hair cells are back on normal degenerative pace." --> I guess once the damage has been done by the excess glutamate, their is no hope for the already dead hair cell. Returning the glutamate production to normal levels and returning the hair cell back to its normal degenerative pace does not help the T... it is already too late. The hair cell is dead and we wish we were chickens!
However, from the complexity of every individuals inner ear physiology, you could just get some strong hair cells, seemingly impervious to excess glutamate past the 3 month marker, that could be saved. Its just a thought and a hope and maybe the reason AM101 people are trialing 300 people in the 3 - 12 month band.
Hi Jaxx. If you do stumble upon that article, i'd love to see it. Holding out for AM101 being useful in the 3 - 12 month window.I believe damage occurs over a longer period--or so this is argued in at least one research article comparing animal to human models. Last year, I encountered this larger window hypothesis, but, unfortunately, did not include the article in my bibliography. Since I do tend to re-read articles, perhaps I'll stumble upon it again in those sidebar references on pubmed. Anyway, if I do find it, I'll post. It'll be interesting to get your opinion.
@benryu Just wanted to give you a shout out for all the expertise and detailed explanations you're providing to this thread and the one on Retigabine. You're the best! Thank you!
Thanks benryu. I feared as much. I am hoping you are wrong ;-) Yet, i fear you are not as u seem to be gifted with an in-depth understanding of this far beyond myself. I am really hoping to see people benefit from AM101 in the 3 to 12 month window.
If they bothered doing a trial on such a time frame, there's maybe the possibility for some potential effect after a longer period than the 3 months.
Thanks StayPositive. Is it a blocked sensation that you feel like you have water in the ear? Is this the feeling that takes 24hrs before your ears are clear again and can hear properly again?
Eek ! 2nd pet hate besides hijacking threads ... the saying "chin up". I think an ENT said it to me once ;-)Don't fear too much, the literature is very weak on those glutamate excess mechanisms, or at least what I can find
That being said, as I mentionned before, I have much more hope for potassium channels treatment than glutamate blocker, even if I think the combination of the two early on will do very good, as the AM-101 may reduce drastically the period of treatment for the AU00063 as eg, and protect your inner ear. But the potassium channel "fix" will still work great alone for chronic T.
Chin up
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