AM-101 TACTT1 Results Released

#181
t-man said:
Actually, I do believe the audio nerve can be damaged from noise. The nerve can be physically burned by a large amount of stimulation from the cochlea. It's like running a larger than normal current through a wire; the shielding burns off, but in the nerves case, this shielding will actually grow back. But in many cases the nerve is damaged and that's where the lack of signal from the cochlea can be.
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But then wouldn't my T be super loud? I don't think it's very loud. How can I know if I have cochlear damage or auditory nerve damage?

Edit: I don't think I have to worry about auditory nerve damage...

http://www.deafwebsites.com/hearing-loss/auditory-nerve-damage.html
 
#183
Does anyone know if they will be having more trials at the U of Miami? I also read somewhere that they might have some at the U of Florida. I looked at the links people posted and the only thing I came away with was a date of march 14th. No locations. My T just started this November so I'm still under 3 months.
 
#184
Hudson said:
I would say "don't look a gift horse in the mouth". By all means, go to concerts if you really enjoy doing it. Just wear hearing protection! I went to many multiple live shows, concerts, fireworks shows, days shooting at the range, etc. over the years after I have had tinnitus. The only time my tinnitus has ever been affected was when I was in a a loud bar without protection. If AM-101 does reach market approval and it helps tinnitus sufferers to a good extent, that will be great! What I don't think it will do is be a magical cure-all. It may tame your tinnitus, but the underlying damage to the auditory system that caused tinnitus in the first place may still exist. This is why it is important to continue to use hearing protection. I would suggest that you continue to use ear plugs around any excessive noise levels until the day comes when they can regenerate hair cells. Which is a "few" years off to say the least. :)
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I have an earplugs related question. If I go to a ar and want to have a conversation with friends (which usually means screaming anyway) can i actually hear over earplugs?
 
#185
Stina said:
I have an earplugs related question. If I go to a ar and want to have a conversation with friends (which usually means screaming anyway) can i actually hear over earplugs?
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I would advise you to buy earplugs with a filter in it, I bought a set for 20 euro they keep the ears safe from loud sounds but let through all sound on reasonable levels without affecting the quality of it
 
#187
#188
Just to let people know, earplugs won't necessarily prevent further damage. When I first got tinnitus I still kept going to concerts with earplugs. Earplugs with a 35dB cut and my hearing still got worse. Plugs can only provide so much protection when immersed in a 100-115 dB environment. And they do very little to protect you from lower/mid-range frequencies. You have to remember our skulls act as giant resonant board for our cochleas.

Of course, some of us humans need to be in a worse situation before we develop a clue.
 
#189
Finally read through all 7 pages of this as is up the on the "possible treatments" list (one day).

I searched the Auris site and this forum trying to find out exactly what this AM101 drug/ingredient is in plain English. I have these below three below:

- "I've read that it's based on ketamine but other than that I'd have no idea if it is ketamine or a derivative of it."

- "AM-111, a dextrorotatory peptide that blocks c-Jun N-terminal kinase (JNK) signaling,"

- "Eskatamine"

Does anyone know more than this or can translate this into a more understandable format??? The reason I ask is because I recently tried IV Ketamine (though via nasal inhalation-absorption) c/o my doc, and was wondering if this stuff is similar.

Thanks - I hope... Zimichael
 
#191
Zimichael said:
Finally read through all 7 pages of this as is up the on the "possible treatments" list (one day).

I searched the Auris site and this forum trying to find out exactly what this AM101 drug/ingredient is in plain English. I have these below three below:

- "I've read that it's based on ketamine but other than that I'd have no idea if it is ketamine or a derivative of it."

- "AM-111, a dextrorotatory peptide that blocks c-Jun N-terminal kinase (JNK) signaling,"

- "Eskatamine"

Does anyone know more than this or can translate this into a more understandable format??? The reason I ask is because I recently tried IV Ketamine (though via nasal inhalation-absorption) c/o my doc, and was wondering if this stuff is similar.

Thanks - I hope... Zimichael
Click to expand...

Hi did you find any relieve from the ketamine absorption this way? ... I was gonna try the same experiment actually. Also because I read that Ketamine can change a lot of brain patterns, so I was hoping ... well you know what I hoped for :)

btw IV ketamine means IntraVenous so you just tried Ketamine.
 
#192
nills said:
Hi did you find any relieve from the ketamine absorption this way? ... I was gonna try the same experiment actually. Also because I read that Ketamine can change a lot of brain patterns, so I was hoping ... well you know what I hoped for :)

btw IV ketamine means IntraVenous so you just tried Ketamine.
Click to expand...

Where do I get this stuff? Please keep us updated on your experiments..
 
#197
cmurem said:
At least ten years but if the problem is from cochlear damage.
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And nobody knows if the hair cell is regenerated, then the T will be cured? Since so many guys said that long term T also got relationship with the brain and memory, so the hair cell regeneration seems to be the root of the hearing loss, but how about T? I don't know, but I personally believe that if the cochlear is perfect, then no T at all:)
 
#200
James White said:
they are supposed to start human clinical trials in 10 years :)
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yeah I also heard smth that if it is reachable for patients in 15 years that optimisic. maybe I got it wrong but I understood that since they don't know what happens when there are too many hair cells it could actually make the condition worse.
 
#201
Aaron said:
And nobody knows if the hair cell is regenerated, then the T will be cured? Since so many guys said that long term T also got relationship with the brain and memory, so the hair cell regeneration seems to be the root of the hearing loss, but how about T? I don't know, but I personally believe that if the cochlear is perfect, then no T at all:)
Click to expand...

I believe yes. I dont believe to memorizing of T.
 
#202
Stina said:
yeah I also heard smth that if it is reachable for patients in 15 years that optimisic. maybe I got it wrong but I understood that since they don't know what happens when there are too many hair cells it could actually make the condition worse.
Click to expand...

Maybe you just get super hearing like a dog
 
#204
I'm not sure I buy the whole "memorization" theory either. If the signal is "jammed" (AM-101?) or the rogue signal is eliminated at the source (Hair cell regeneration), I see no reason why the tinnitus would permanently remain. Sure, I could see it taking a little while for everything calm down up there, but the brain has an amazing ability to adapt and readapt to a stimulus (or lack there of).
 
#206
To get back on track, I found out today that the University of Iowa and KU Med in Kansas City, Kansas are both participating in the Phase III AM-101 trials (which should be starting within a week, according to who I talked to). That's as much info as I have for the midwest region of the US. I'm imagining that the Mayo Clinic will be participating as well, given their size and reputation for being cutting edge with research, but I can't confirm that for sure.
 
#207
Hudson said:
To get back on track, I found out today that the University of Iowa and KU Med in Kansas City, Kansas are both participating in the Phase III AM-101 trials (which should be starting within a week, according to who I talked to). That's as much info as I have for the midwest region of the US. I'm imagining that the Mayo Clinic will be participating as well, given their size and reputation for being cutting edge with research, but I can't confirm that for sure.
Click to expand...

Do you happen to know what the entrance requirements are for the study? I live within 20 minutes of the KU hospital haha
 
#208
This has been posted many times before but I'll repost for any newbies out there:

Criteria
Inclusion Criteria:

  1. Persistent subjective peripheral tinnitus (unilateral or bilateral) following traumatic cochlear injury (acute acoustic trauma, blast trauma, middle ear surgery, inner ear barotrauma, tympanic membrane trauma) or otitis media with onset no longer than 3 months prior to randomization
  2. Age ≥ 18 years and ≤ 75 years;
  3. Negative pregnancy test;
  4. Willing and able to use adequate hearing protection, respectively to refrain from engaging in activities or work involving loud noise exposure where sufficient hearing protection is not possible or ensured;
  5. Willing and able to protect ear canal and middle ear from water exposure as long as tympanic membrane is not fully closed;
Other protocol-defined inclusion criteria may apply.

Exclusion Criteria:

  1. Fluctuating tinnitus;
  2. Intermittent tinnitus;
  3. Tinnitus resulting from traumatic head or neck injury;
  4. Presence of chronic tinnitus;
  5. Meniere's Disease, history of endolymphatic hydrops, or history of fluctuating hearing loss;
  6. History of repeated idiopathic sudden sensorineural hearing loss or history of acoustic neuroma;
  7. Ongoing acute or chronic otitis media or otitis externa;
  8. Other treatment of tinnitus for the study duration;
  9. Known hypersensitivity, allergy or intolerance to the study medication or any history of severe, abnormal drug reaction;
  10. Women who are breast-feeding, pregnant or who are planning to become pregnant during the study;
  11. Women of childbearing potential who are unwilling or unable to practice contraception, such as hormonal contraceptives, double barrier, sexual abstinence or intercourse with a partner who has been vasectomised for at least three months;
  12. Concurrent participation in another clinical study or participation in another clinical study within 30 days prior to randomization.
Other protocol-defined exclusion criteria may apply.
 
#210
on a side note;

Interestingly it should be noted many individuals who use amplification regularly find that tinnitus is suppressed for many hours after the hearing aid has been removed. Practically speaking, amplification is one of the most useful methods of tinnitus control in individuals whose hearing loss is sufficiently severe to benefit from this modality.

which means that if hearing ability is reversed in hearing loss - tinnittus will disappear ... forget all about brain memorizing and that stuff ... it goes :)
 

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