It's really hard to say because I've been on several prescription meds and so many different supplements. Since the start of this 3 months ago, I always take a multivitamin, Magnesium, Fish Oil, Nicotinamide Riboside, Astaxanthin/Zeaxanthin, and a few other things have come in and out of rotation (Curcumin, Melatonin etc...). The top of my dresser literally cannot fit any additional pill bottles on it. If it is reputed to help, I've probably purchased it. When I first had mild tinnitus that went away over a few years, I swear Chelated Magnesium helped calm it and, I think, helped with recovery. I basically take this until it starts acting as a laxative, and then start taking half doses each day - I would say an average of 300 mg daily.
In terms of meds, the only things which I can point to with a degree of confidence in terms of making a meaningful difference for the tinnitus volume are Pramipexole, Xanax, and Prednisone (I am on Prednisone now following an incident with a fire alarm, but cannot continue that indefinitely obviously, and same with Xanax - I take it as needed). Xanax basically turns the volume down by half or more for me, depending on the day, but I only use it once per week for a tinnitus vacation for fear of tolerance. Benzo analogues seem to have a smoothing effect - Kava Root and Valerian, both of which also act on GABA receptors, can definitely take the edge off of the noise, but I also try to ration their use, because they act on the same systems as Xanax and could lead to tolerance as well (probably not alone, but in concert with Xanax). For sleep, Mirtazapine and Nortriptyline work great to knock me out, but I've also gained the ability to sometimes nap and sleep in in the mornings over time.
At the beginning, most days were agony where literally all I could do was will myself through existence - the tinnitus was extremely loud and powerful. I slept in a tent outside whenever I could because crickets/cicadas helped mask a great deal - our family friends have a large dead patch on their lawn where I spent all of my time. Now I get some good days and some bad days. Good days started at about 2.5 months, when the tinnitus became largely atonal, and more of a buzzing noise. I find this easier to tolerate. Bad days, when the tinnitus becomes louder and/or tonal again, usually follow some ordinarily innocuous, impossible to avoid noise exposure, like when I'm moving around my room and something falls off a shelf, my cat knocks over a vase, etc... the fire alarm going off when cooking briefly pushed me back to interminable suffering levels, but Prednisone seems to have calmed that down by about 80% - I do fear when I finish my course the interminable level will resume. Bad days can also happen for seemingly no reason, but the more excessive noise I avoid, the better off I seem to be.
Overall I would say I started at an 8-9/10 where I intimately understood the rationale for euthanasia, and now range from a 4-7/10 - my hope would be to get back to a 2-3/10 with a higher sound tolerance so that I can go back to work. My greatest fear is another noise event that pushes me back to suicide levels, but I am hopeful regenerative medicine, neuromodulation, and more targeted medications will help bring this condition to a guaranteed manageable level, or a thing of the past, and that as I age, each of those options will mature.
Sorry for the essay but I wanted to be exhaustive.
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