I assume you are talking about your symptoms from the poisoning. How do you know the amount of MSG that you consumed?
No I'm not. It's called a storm for a reason. It typically happens suddenly in large parts of the brain and results in what could be seen as catastrophic damage. The word storm has been chosen to make the analogy to something that comes in fast and wrecks havoc.
As I understand it Benzo's drive up the production of GABA. Should you suddenly stop to provide the brain with artificial incentive to metabolize that glutamate into GABA, which is the only thing that can save you from all that glutamate, you're going to have a severe problem with elevated levels of intercellular glutamate. I'm pretty sure it says in the pack booklet that you can not stop taking benzo's cold turkey if you've taken them for a longer period.
The acute symptoms of MSG ingestion are well known, both with my academic internist, and in literature. There is a physical lower reaction, and a clear visual upper, limit to the dose. And finally the brain barrier permeability that was taken into account to calculate the systemic dose, and ingested doses.
glutamate excitotoxicity triggered by acoustic trauma?
This is not colloquially known as a storm.
From my understanding acoustic traumas can immediately kill the hairs or nerve connections in extreme cases like an explosion, but more often the connections to the nerves weaken and begin to die off over days to months.
You've mixed up three different things here; Acoustic trauma that kills hair cells, acoustic trauma that does not kill hair cells allowing them to excite the axon to death, and an unspecified form of neuronal degeneration over time. I'm not familiar with a mechanism of action in which acoustic damage could cause neural degeneration over time.
For me, I suffered a short duration acoustic trauma that I knew right away affected my hearing, but the loud ringing did not set in till several days later. In hindsight, I'm pretty sure it affected my ultra high frequency hearing and that's where my tinnitus lies.
Tinnitus does not result because of hearing damage per se. The problem lies in the signal processing of the CNS. The CNS periodically monitors the signal coming from the ears and eyes and cleans it up by setting a threshold of hearing per frequency to mask sounds not coming from the outside world.
When the synapses in the cochlea or anywhere in between the cochlea and other filtering centers go nuts, the signal will no longer be interpreted as internal noise because a sufficient number of synapses are giving the same signal at the same time. This is why we get a relatively high volume of tinnitus suddenly as opposed to gradually increasing.
The mechanism here is not as sophisticated as it may seem, it emerges naturally from the way the circuit is hooked up. The reason I know this is because as an amateur astronomer and neurology hobbyist I had simulated the optical nerves and calculated the thresholds because we wanted to learn about our limits with the naked eye.
According to that presentation the CNS filters signals by proportion, meaning that when 5% of the signal is a high pitched noise you're fine. Until you lose 90% (arbitrary) of the other synapses, in which case 50% of what is left is creating a noise that your CNS no longer interprets as noise to be filtered.
There are multiple ways solve this problem, AM-101 attempts to inhibit the signal being produced at the synapses, it is a targeted non competitive neural inhibitor. The doctor also mentioned that repair of the ribbons would help, the question is whether we can repair them so long after damage. The problem is that the glia clean up the dead cells and you're left with a very clean loss of neurons. The question here is whether BDNGF can cause the synapses that are left to sprout new dendrites to increase the population on which to base the signal filtering. Another way is to change the threshold of noise filtering in the brain stem by means of devices like the mute button, or the vagus nerve stimulator.
That's a very interesting presentation. I believe I can very easily develop a way to do Auditory Brainstem Response Audiometry. I'll look into that.
To summarize, whatever your cause, the end result is the same for all tinnitus sufferers, and so are the solutions. To remain relevant to the thread, if you're expecting a glutamate storm, the best thing you can do, the same that an ambulance would make you do, is to ingest large amounts of vitamin C, anything above 2 grams is fine.
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, that your presence and input on this site is a gift. I enjoy reading your mind (ha ha - I mean: reading the CONTENTS of your mind) and am grateful for your posts.
