Anyone on Erenumab (Aimovig) for Migraine? Have You Noticed Any Effect on Tinnitus?

[Krolo]

So after some looking on the Internet I found this new treatment for migraine which targets Calcitonin gene-related peptide receptors, which by some means seems to be in the cochlea among other areas:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115147/

Calcitonin-gene related peptide (CGRP), a 37 amino acid neuroactive peptide, is expressed in the auditory and vestibular systems (Wackym et al., 1993; Maison et al., 2003a; Ahn et al., 2009; Xiaocheng et al., 2013). In the central auditory system, CGRP-positive neurons can be found in the lateral superior olivary nucleus.
---
In the periphery of both systems, CGRP colocalizes with ChAT, the enzyme that catalyzes the synthesis of acetylcholine (ACh). This colocalization is observed in the varicosities of efferent fibers, suggesting that CGRP and ACh function together to modulate peripheral auditory and vestibular sensory function.
---
GRP loss did not affect cochlear auditory thresholds or distortion-product otoacoustic emissions, yet mice showed a striking ∼20% reduction in suprathreshold cochlear nerve sound-evoked activity. It is not yet known whether or how the loss of CGRP influences vestibular system function.​

Botox seems to have the same effect on CGRP as Erenumab:

https://medicalxpress.com/news/2018-05-germ-flesh-eating-disease-hijacks-neurons.html

Since this is a new drug I wonder if anyone here has tried it for migraines and have had their tinnitus change?

 

[Lane]

Since this is a new drug I wonder if anyone here has tried it for migraines and have had their tinnitus change?

Hi @Krolo -- Thanks for posting this. I too would be interested...

 

[Arseny]

Where can I buy it?

 

[Striveon]

Interesting... @hurtingdream

 

[Codaz]

So after some looking on the Internet I found this new treatment for migraine which targets Calcitonin gene-related peptide receptors, which by some means seems to be in the cochlea among other areas:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115147/

Calcitonin-gene related peptide (CGRP), a 37 amino acid neuroactive peptide, is expressed in the auditory and vestibular systems (Wackym et al., 1993; Maison et al., 2003a; Ahn et al., 2009; Xiaocheng et al., 2013). In the central auditory system, CGRP-positive neurons can be found in the lateral superior olivary nucleus.
---
In the periphery of both systems, CGRP colocalizes with ChAT, the enzyme that catalyzes the synthesis of acetylcholine (ACh). This colocalization is observed in the varicosities of efferent fibers, suggesting that CGRP and ACh function together to modulate peripheral auditory and vestibular sensory function.
---
GRP loss did not affect cochlear auditory thresholds or distortion-product otoacoustic emissions, yet mice showed a striking ∼20% reduction in suprathreshold cochlear nerve sound-evoked activity. It is not yet known whether or how the loss of CGRP influences vestibular system function.​

Botox seems to have the same effect on CGRP as Erenumab:

https://medicalxpress.com/news/2018-05-germ-flesh-eating-disease-hijacks-neurons.html

Since this is a new drug I wonder if anyone here has tried it for migraines and have had their tinnitus change?

Botox is very poorly understood. All doctors that I have visited for my chronic pain from anesthesiologists to gnathologists to jaw surgeons, they all knew about it but never have done it. Also the effects of botox are vastly downplayed. It is toxic. They all say well it dissapears within 3 months. But nobody knows where it flows if they inject it.

 

[Miss Black]

I just received my first Aimovig shot a week ago. My tinnitus spiked the day I received it and it has not returned to normal. CGRP is a potent vasodilator and there are receptors in the cochlea. Inhibiting CGRP results in vasoconstriction, and I believe this is what caused by tinnitus to spike.

 

[Pre55ure]

I just received my first Aimovig shot a week ago. My tinnitus spiked the day I received it and it has not returned to normal. CGRP is a potent vasodilator and there are receptors in the cochlea. Inhibiting CGRP results in vasoconstriction, and I believe this is what caused by tinnitus to spike.

Thank you for this info.
Please update this with your progress and let us know if it goes back to baseline.
I hope you are doing better.

 

[SonnyB]

I joined this forum just to relay my experience on Emgality (another CGRP medication, prescribed for chronic migraine). After 4-5 days, it spiked my tinnitus terribly, gave me really bad joint pain, and have moderate ear pressure also. Given it's long half life (28 days), I'm quite upset that I'm likely in this for the long haul. @Miss Black, would love to know if your tinnitus reverted to baseline after stopping the medication.

 

[debbyw]

I just found this forum and decided it might be worthwhile to comment. I've had mild tinnitus for a number of years, I've also suffered from migraines for decades. I am unable to take any Triptan meds as these increase the headache pain.

I have been taking Aimovig injections for 4 months now. I went from 2-4 migraines a week to have had maybe 4 since beginning the injections. First month zero headaches. Since my most recent injection I've had constant, sometimes two-tone tinnitus. It's so frustrating. If I'm really busy I don't really notice it... but of course with COVID-19 stay at home etc I've been pretty bothered by it. Tinnitus is not listed as a side effect... but I wonder since that is the only big change.

 

[Roxxe68]

I recently started Nurtec for migraines (oral CGRP). I started noticing tinnitus after taking. It would last 2-3 days then go away. Well after my last dose I have had constant tinnitus for 12 days now. I never had tinnitus before Nurtec.

Has anyone else experienced this with CGRPs and had it ever go away?

 

[Violant]

I'm been with Aimovig since last April. I think my tinnitus has gotten worse. I'm not suere if it is due Aimovig.

 

[Julie P]

I used Aimovig for 4 months and my headaches got tremendously worse the fourth month so I switched to Emgality. The first month it was absolutely wonderful. I only had 2 migraines instead of my usual 14/month.

The second month of Emgality my ears started ringing after just a few days. It is constant plus I've already had 5 migraines in the first 10 days.

Please tell me the tinnitus will stop after this injection wears off. I hate the migraines but the ringing is driving me insane.