Audion Therapeutics Trial

[tarmaced]

It sound very positive if they have enough confidence to inject both ears.

Sorry, I have scanned the above posts, where is this? I'm probably being blind lol, today had been bad.

 

[Coleoptere]

Sorry, I have scanned the above posts, where is this? I'm probably being blind lol, today had been bad.

... gel-like medicine injected in his ears,

 

[Mathieulh]

It almost has to be a gel. If it was a low viscosity liquid it would immediately flush out through the eustachian tubes without plugging them first.

It's most likely a gel, because that's what makes sense from a practicality standpoint, although there are a few maneuvers one can do to temporarily close the Eustachian tubes, of course that would rely on the patient performing those, so using a gel would be more efficient.

 

[Mathieulh]

Actually the Trobalt redesigned is being developed by Prof. Tzounopoulos att University of Pittsburgh. He recently secured funding from the US military to go ahead with a trial of his potassium ion channel drug aimed for tinnitus.

Not to sound like a party crasher, but I am definitely not using this unless I am desperate, so many things can go awfully wrong by messing with potassium ion channels, it's not like the drug can target a specific area in the brain, so it has to be broad to some degree, that's enough to cause potential serious (and irreversible) side effects to a lot of people. There is a reason Trobalt was eventually discontinued.

 

[Mathieulh]

@gadsie - UK Trials are held in London

https://www.regainyourhearing.eu/trial/

I don't like how they exclude tinnitus patients from their trial, there are patients with objective hearing loss that have tinnitus, excluding those means we will have no data whatsoever on the impact of thus drug on tinnitus.

Sadly, I don't fit the criteria for this trial as I have no perceivable hearing loss and use no hearing aid.

 

[Mathieulh]

That's the million dollar question! Presumably, if they can grow functioning hair cells, the hope is that tinnitus will also be diminished.

It's not the stereocillia that tinnitus sufferers have to worry about, it's the underlying peripheral neuropathy, this is what causes the tinnitus, whereas damaged/dead stereocillia only cause hearing loss, this is why most people experience some form of hearing loss without tinnitus, it has nothing to do with our brains being different and everything to do with the type of damage sustained.

Of course restoring sterecillia alone isn't going to achieve much if it's not attached to a nerve ending, restoring the nerve would actually get rid of the noise, (without restoring hearing itself) whereas restoring both the nerve and stereocillia would let people get their hearing back and heal tinnitus.

Of course if you don't have tinnitus, this means your nerve is still fine and restoring stereocillia alone would indeed fix your hearing to some degree.

 

[tarmaced]

... gel-like medicine injected in his ears,

I think I am am optimist, but I struggle to envisage them treating both ears in direct contradiction of the stated trial criteria and control? Not arguing with other aspects of statement though.

Can we ask a follow up question?

 

[Enclave]

I think these are irrelevant semantics. There are also products that call themselves "liquid gel". What is that then?

This individual's anecdote is here-say, and this anecdote is supported by an "anonymous source", and within this anecdote there exists inaccurate information.

This is what I'm pointing out. Semantics are important, but go ahead and believe everything that you read.

 

[Coleoptere]

I think I am am optimist, but I struggle to envisage them treating both ears in direct contradiction of the stated trial criteria and control? Not arguing with other aspects of statement though.

Can we ask a follow up question?

Of course, but ask @síocháin, she is the source of the story and can clarify.

 

[Lucifer]

http://www.isrctn.com/ISRCTN59733689

They changed the publish date for Phase 2 results from 31/01/2020 to 30/04/2020. But at this stage it still seems Audion is way ahead compared to Frequency Therapeutics.

 

[Coleoptere]

31-1-2020 was mentioned on the site for a few years. Else they mentioned early 2020.

 

[Coleoptere]

Does somebody know of any results from pre-clinical tests of LY3056480 ?

 

[Lucifer]

Does somebody know of any results from pre-clinical tests of LY3056480 ?

Not that I'm aware of. The only person we know who has success with this drug is through a mutual friend of @síocháin.

@síocháin do you know whether your mutual friend is part of Tinnitus Talk and is willing to tell us about his experience from using the drug?

 

[JohnAdams]

So if these reports are true then this is it. The treatment for hearing loss and tinnitus exists.

 

[JohnAdams]

Seriously, if these anecdotes are true, which they probably are, then our redemption is sitting on shelves in lab supply companies. The barrier to having our lives restored is now government red tape.


Completely unacceptable.

 

[Lucifer]

@JohnAdams I believe the drug works. Who's going to release it first, I reckon Regain.

 

[JohnAdams]

@JohnAdams I believe the drug works. Who's going to release it first, I reckon Regain.

We need to somehow think of a way to make this available sooner. If possible.

 

[Lucifer]

We need to somehow think of a way to make this available sooner. If possible.

I agree. If it works now and has no side effects it should be released as soon as possible.

 

[JohnAdams]

and has no side effects

when they were testing ly411575 on rodents, first they experimented with oral administration at a much higher dose. It caused their hair to fall out, their skin turned green and they got skin tumors.

 

[Lucifer]

when they were testing ly411575 on rodents, first they experimented with oral administration at a much higher dose. It caused their hair to fall out, their skin turned green and they got skin tumors.

It worked better when it was injected in the ear and had fewer side effects. Hopefully results are positive again next year with Phase 2 data so they can speed up the process.

 

[JohnAdams]

It worked better when it was injected in the ear and had fewer side effects. Hopefully results are positive again next year with Phase 2 data so they can speed up the process.

yeah that's the entire point with injecting it into the ear. we should be very thankful that there is a semipermeable membrane to the inner ear.

 

[John Queen]

Well, until they get the drug approved... Meanwhile in Korea, Russia, China and a few other countries after Phase 2 results will be published:

 

[ThomasC]

So, if i understand, they have already cleared phase 2 , and will publish the results next year.
Any idea when they will start the third phase ?

 

[Lucifer]

So, if i understand, they have already cleared phase 2 , and will publish the results next year.
Any idea when they will start the third phase ?

I don't think they are done with Phase 2 yet. Results will be publish end of April 2020, originally it was end of January 2020. I assume once they publish results hopefully they move onto Phase 3. Now there is some good competition between Regain/Audion and Frequency Therapeutics.

 

[JohnAdams]

so here we have the closest hope of a cure for our situations and there is very little excitement. absolutely pathetic.

 

[FGG]

so here we have the closest hope of a cure for our situations and there is very little excitement. absolutely pathetic.

I predict massive excitement in April if phase 2 results are good.

 

[JohnAdams]

Some, like, government people need to feel sorry for us and get them to hurry up.

 

[Auron]

so here we have the closest hope of a cure for our situations and there is very little excitement. absolutely pathetic.

Excitement from whom?Us,here on the forum?

 

[JohnAdams]

Excitement from whom?Us,here on the forum?

in part, yes

 

[FGG]

Not to sound like a party crasher, but I am definitely not using this unless I am desperate, so many things can go awfully wrong by messing with potassium ion channels, it's not like the drug can target a specific area in the brain, so it has to be broad to some degree, that's enough to cause potential serious (and irreversible) side effects to a lot of people. There is a reason Trobalt was eventually discontinued.

Kv3.1 channel drugs would be pretty specific for the auditory system since that type is at a much higher concentration there (including auditory brainstem, which can be affected by some ototoxins). Probably would have less side effects than the broad spectrum channel opening drugs, too.

On its own, KV3.1 drugs could help hearing but is probably less effective for tinnitus on its own based on Autifony's failed tinnitus trial. Different ion channels (or different formulation or drug) may be a different story.

Personally, Kv3.1 drugs have the potential to help my hearing immensely since I likely have both cochlear and brain stem involvement but I'm not sure if I would be the norm there. I do see more mild and more targeted channel drugs as helping a lot of people with various conditions, though.

Edited to add: most tinnitus targeted channel opening drugs are being tested on different channel types than kv3.1.