JohnK
Member
- Nov 10, 2015
- 311
- Tinnitus Since
- 10/26/2015 (habituated) 5/13/2019
- Cause of Tinnitus
- Doxycycline (2015) Otimize ear drops [neomycin] (2019)
Auris Medical (AM-102)
- Thread starter attheedgeofscience
- Start date
Funny thing: Let's say AM-101 goes into the market being a med for acute T. Let's say AM-102 does well and goes into the market along with AM-101. Let's say the first is used upto 6 months and the later for later. What can a person with T for about 5.9 months take? AM-101 or AM-102? Perhaps start the therapy with one and finish with the other?
This acute consept for meds that we do not yet know if they even work is simply ludicrous...
I say they have to be 2 completely different therapies with completely different objectives: The first (AM-101) being for retaining the inner ear health in acute stage of trauma, meaning a few days and not 6 months (like the alleged corticosteroids being the only thing for acute T). Saving all it can save before permanent damage.
And the other (AM-102) will be for correcting/repairing the damage. So it will have to be a completely different approach. The names are similar only for code naming reasons...
Either that, or we are to face great disappointment. Another factor to take into account is that the science behind inner ear restoration is rapidly advancing forward, stem-cells and gene therapies are being tested, meaning the AM-102 may be obsolete before it even starts trials... Perhaps that is why they don't even know the exact way it will function themselves yet... hence the "undisclosed" sign. Because this med is simply just a project name for chronic tinnitus containing an unknown therapy as of yet! It is not likely they already posses a cure for tinnitus but instead prefer to go on with their acute med trials.
Just my 2 cents...
This acute consept for meds that we do not yet know if they even work is simply ludicrous...
I say they have to be 2 completely different therapies with completely different objectives: The first (AM-101) being for retaining the inner ear health in acute stage of trauma, meaning a few days and not 6 months (like the alleged corticosteroids being the only thing for acute T). Saving all it can save before permanent damage.
And the other (AM-102) will be for correcting/repairing the damage. So it will have to be a completely different approach. The names are similar only for code naming reasons...
Either that, or we are to face great disappointment. Another factor to take into account is that the science behind inner ear restoration is rapidly advancing forward, stem-cells and gene therapies are being tested, meaning the AM-102 may be obsolete before it even starts trials... Perhaps that is why they don't even know the exact way it will function themselves yet... hence the "undisclosed" sign. Because this med is simply just a project name for chronic tinnitus containing an unknown therapy as of yet! It is not likely they already posses a cure for tinnitus but instead prefer to go on with their acute med trials.
Just my 2 cents...
Member
You have seemed intent on seeing Auris fail since the day you joined, not just in posts, but in messaging everyone currently in the trials telling us how you think the drug made us permanently worse. I'm sorry if you had a bad result, but no... the clinical trials were not a 'scam', and things like that can have an influence on data. Drugs have side effects, some times they don't work, that's why you do clinical trials.
As far as AM-102. I have no idea. If it is just another NMDA receptor antagonist I don't see it being much more effective than AM -101 months after tinnitus onset. But the proposed mechanism of action has not been released.
Sebastians
Member
- Jan 12, 2016
- 375
- Tinnitus Since
- 10/2015
- Cause of Tinnitus
- Guitars, loud girls and guns
You sound like a broken record dude. I really sympathise with your situation, but i am also glad there are companies out there putting their ass on the line to find a cure for T. Your worsening has imho nothing to do with am101 but with procedure related risks. If anything, be angry at the doctors who injected you. Perhaps you could also disclose the name of the facility.
U are a joke, if you were at the helm of tinnitus research we'd never get anything.
Ian Mac
Member
- Jun 1, 2016
- 321
- Tinnitus Since
- 2011
- Cause of Tinnitus
- Vestibular Nueritis, loud music (dubstep)
There's no difference between acute and chronic T as we've learned Tinnitus can arise months after the actual trauma. Therefore this drug is more intriguing than am101 because I think trying to treat acute T is a joke. Am102 is aiming to treat chronic T so that's sweet. However I do not have much expectations because it hurts to get let down, Also this would probably not cure my T because I had Labrythitis...
Ian Mac
Member
- Jun 1, 2016
- 321
- Tinnitus Since
- 2011
- Cause of Tinnitus
- Vestibular Nueritis, loud music (dubstep)
Guess it just popped into my brain because people have said that.
When you look at their spreadsheet it shows am101 is for "Acute Tinnitus" yet next to Am 102 it just says "Tinnitus"
Seems more promising since acute at is a joke.
When you look at their spreadsheet it shows am101 is for "Acute Tinnitus" yet next to Am 102 it just says "Tinnitus"
Seems more promising since acute at is a joke.
Seems like that way. Who know whats going on but im praying every single day for a breakthrough from something that will quiet these insane noises! Up most of the night last night hissing away. No rest. Hard to function next day. on and on and on.....
I'm sure I read it somewhere (AM102 targeted at chronic T), in an interview I think. I'll find the link.
- May 8, 2012
- 1,601
- Tinnitus Since
- 04/15/2012 or earlier?
- Cause of Tinnitus
- Most likely hearing loss
If the TRI determined in 2015 that tinnitus was a brain issue
We will not know till the end of the year
Erik,
Thank for your reply,
i read some where that auris had success with AM-111
and also that patients with sudden hear loss and tinnitus had total remission of both symptoms.
but then again... if they had remission and success with am-111
why might have wrong with am-102
sorry maybe im asking questions that can not be answered lol
Do you mean went wrong with am-101? AM-111 has a different mechanism of action. Quoting form their website:
http://www.aurismedical.com/product-candidates/am-111
Thank Alue,
i dont understand if AM-111 did great, why it isnt out in the market?!
this could have helped me... in the first place.
He|ix
Member
I founf this agreement with auris which goes all the way back to 2003.
https://www.sec.gov/Archives/edgar/data/1601936/000119312514253454/d684505dex101.htm
https://www.sec.gov/Archives/edgar/data/1601936/000119312514253454/d684505dex101.htm
Mario martz, could you post the thread about the definite effect of AM-111, and it means total remission or totally cured?
Perhaps he was talking about
http://www.ncbi.nlm.nih.gov/pubmed/24979398
AM-111 0.4 mg/ml showed statistically significant, clinically relevant, and persistent improvements in hearing and speech discrimination and higher tinnitus remission compared with placebo. The study drug and the intratympanic injections were well tolerated.
Ian Mac
Member
- Jun 1, 2016
- 321
- Tinnitus Since
- 2011
- Cause of Tinnitus
- Vestibular Nueritis, loud music (dubstep)
The mice they experiment on, I pray for their souls.
The humans they experiment on, I pray for their souls.
Because we have no idea what's going on! The problem can be in the brain but in another person in the nerves of the ears and another person can have T from body posture, and another thousands of people have toxic fungus virus and bacterial sources that really fuck yo auditory system. "TINNITUS" is not even a real thing, like they say it's a symptom of one of the above causes, which sucks because it makes it impossible to diagnose the CAUSE and treat. In theory Once we know the cause we can start treatment to remedy the damage, but as of now we don't have any treatments even if you could identify the source.
The humans they experiment on, I pray for their souls.
Because we have no idea what's going on! The problem can be in the brain but in another person in the nerves of the ears and another person can have T from body posture, and another thousands of people have toxic fungus virus and bacterial sources that really fuck yo auditory system. "TINNITUS" is not even a real thing, like they say it's a symptom of one of the above causes, which sucks because it makes it impossible to diagnose the CAUSE and treat. In theory Once we know the cause we can start treatment to remedy the damage, but as of now we don't have any treatments even if you could identify the source.
To me...
the problem is in the ear!! of course, and then its a connection to the brain that must be damaged.
there is nothing wrong with the brain in the first place.
my noise get bad when eating sugar, salt or msg.
because it some hows excites this "connection"
thats why i think of it...
like its a wire from the ear to the brain.
that why we need cellular repair.
the problem is in the ear!! of course, and then its a connection to the brain that must be damaged.
there is nothing wrong with the brain in the first place.
my noise get bad when eating sugar, salt or msg.
because it some hows excites this "connection"
thats why i think of it...
like its a wire from the ear to the brain.
that why we need cellular repair.
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