Autifony Therapeutics Phase I Study for AUT00063, for the Treatment of Hearing Loss and Tinnitus
- Thread starter Hudson
- Start date
Could I politely suggest that we try not to inundate the doctors at Autifony with emails? It's not going to bring the trials any closer, and the only outcomes I can see are a) they stop responding to emails or b) they take the time to respond, despite the delays it means in actually getting the trial up-and-running.
Just a thought, not trying to pressure anybody.
Just a thought, not trying to pressure anybody.
MemberI think it is there job to answer question and it will resolve certain uncertainties that are arising around these trials that we as people of this world and future payers of this medicin are allowed to question. I think it is good to ask question. Maybe they will discover that a FAQ page would be a good idea on their website.
I agree that an FAQ would be most helpful. Has anyone suggested they do something like this?
But I also agree that we should not flood the doctors' email boxes with our letters. It might discourage them from answering.
Sure tinnitus can be static or change anytime after onset, that's precisely what defines tinnitus! But it's profound variability, apparent diverse etiology and overall indefinable nature may hopefully belie a singular truth, a source generator site. Tinnitus is after all ironically a condition of (auditory) illusion.
The overall elusive and mercurial nature of this condition may be part of the bigger illusion by which this neuronal synchrony survives. Natural selection has a smart way indeed of operating right down to the molecular level. But as many roads lead to Rome, one's 'unique' tinnitus may in fact share a commonality, namely and simply hyper-active auditory neurons. Even if this does not apply to every single case, it will certainly apply to millions of us and more.
True it is that untold sums have been thrown at cancer, ms, etc, and save some advances, there is no front page cure, but the science miracle (HIFU,etc) is gathering pace faster than you might think. You and your loved ones can look forward to longer healthier lives.
Furthermore, tinnitus is not a disease, it is a symptom of a disorder, which may be easier to fix than errant cell behavior within a rebellious immune system. In the near future, tinnitus may be likened to something as eminently fixable as a painful verruca. Wouldn't that be something.
Do not think that just because it can be a very challenging condition that it must be equally challenging to resolve. My optimistic leaning is that tinnitus has led poorly-funded research an un-merry dance around the brain and we have now found something. In fact, the real luck lies in the speed with which AUT00063 has surfaced to address that something.
If University of Leicester have got it right that tinnitus is a product of uncontrolled activity caused by dysfunctional potassium channels and the AUT00063 molecule acts to correct this problem, which it has been shown to do (hence investors climbing aboard the fast-track), there is room for realistic optimism.
The people at Autifony will hopefully be delighted by the deluge of interest in their baby. It's important that they know demand is overwhelming, as demand is a market force which leads to investment. Don't worry, when their inbox is bulging they'll set up a comprehensive FAQ page furnished with wisdom from all your posts!
Being optimistic is not pointless. Optimism is an energy that can change the world.
Yes, none of us are fools. But anything is possible and this may be a good time to be optimistic.
The overall elusive and mercurial nature of this condition may be part of the bigger illusion by which this neuronal synchrony survives. Natural selection has a smart way indeed of operating right down to the molecular level. But as many roads lead to Rome, one's 'unique' tinnitus may in fact share a commonality, namely and simply hyper-active auditory neurons. Even if this does not apply to every single case, it will certainly apply to millions of us and more.
True it is that untold sums have been thrown at cancer, ms, etc, and save some advances, there is no front page cure, but the science miracle (HIFU,etc) is gathering pace faster than you might think. You and your loved ones can look forward to longer healthier lives.
Furthermore, tinnitus is not a disease, it is a symptom of a disorder, which may be easier to fix than errant cell behavior within a rebellious immune system. In the near future, tinnitus may be likened to something as eminently fixable as a painful verruca. Wouldn't that be something.
Do not think that just because it can be a very challenging condition that it must be equally challenging to resolve. My optimistic leaning is that tinnitus has led poorly-funded research an un-merry dance around the brain and we have now found something. In fact, the real luck lies in the speed with which AUT00063 has surfaced to address that something.
If University of Leicester have got it right that tinnitus is a product of uncontrolled activity caused by dysfunctional potassium channels and the AUT00063 molecule acts to correct this problem, which it has been shown to do (hence investors climbing aboard the fast-track), there is room for realistic optimism.
The people at Autifony will hopefully be delighted by the deluge of interest in their baby. It's important that they know demand is overwhelming, as demand is a market force which leads to investment. Don't worry, when their inbox is bulging they'll set up a comprehensive FAQ page furnished with wisdom from all your posts!
Being optimistic is not pointless. Optimism is an energy that can change the world.
Yes, none of us are fools. But anything is possible and this may be a good time to be optimistic.
I hope that they find a way to help us with T and for all the Soldier out there. My Husband was in the Air force for 22 years he has t but manages very well, as for me I'm new at this and having a hard time I have to go back to My Dr Need tricare to aprove going to a ENT. Thank you kind souls for all the information.
I'd like to think most serious researchers would not spend much time, if any, answering random emails. Most receive dozens on various subjects each day. Personally I'd rather they spend more time in the lab. Service is a large time sink.
- Aug 14, 2013
- 2,455
- Tinnitus Since
- Resolved since 2016
- Cause of Tinnitus
- Unknown (medication, head injury)
These are all small companies. By "these", I mean Auris Medical, Autifony, GenVec, etc.
Number Of Employees
1) Auris Medical = 8
2) Autifony = 9
3) GenVec = 11
It's unclear whether the above employees only include people officially working at headquarter entities (ie. there could be other background personnel). But generally, these are small companies - for sure they would not have a customer service unit. This can also be seen by their raised capital - which is quite modest given that they don't make a turnover (yet); admittedly, Auris Medical was listed as having M$ 3 in revenue sales, but I don't know where that would come from since they don't have a finished product yet and therefore nothing "to sell" (not sure the info is accurate; haven't had time to double check it).
Raised Capital
1) Auris Medical = CHF 75M (as per official company financial information, data release of AM101 Phase III is scheduled for completion by EOY 2015; I would assume this means that the finished product cannot be released to market before 2016 - at the earliest - but I could be wrong; phase II and III could be run separately).
2) Autifony = $ 25,4M (officially Autifony has two products listed (both named AUT00063) - one for tinnitus and one for hearing loss, but I believe it is the same product listed twice over; startup for Phase IIa is officially scheduled for 2014 as per financial information).
3) GenVec = $ ?M (this raised capital would probably also be used for other purposes than hearing loss R&D; GenVec has two products listed - both being preclinical; clinical trial for CGF166 hearing loss is scheduled for startup in 2014 as per financially listed information).
As I work in finance, I have often used financial information as a source of indirect company information. I don't normally track down information on medical companies, but the above information is at least "roughly accurate".
So I agree with some of the earlier posts; stop contacting them unless absolutely necessary - they don't have the manpower. Often it is the CEO him- or her-self responding to phone calls and e-mails. My advice.
- Jul 21, 2013
- 842
- Tinnitus Since
- 01/2013
- Cause of Tinnitus
- Acoustic trauma from headphones
You deserve an MVP rating for how informative you can be.
With a different viewpoint, as a company founder, I actually enjoy responding to questions from people about my company. A lot of them are excited about what they're doing since it's potentially groundbreaking. Just don't spam them and expect all the answers, since they're still learning themselves.
interesting power point presentation from them.......
http://www.anglonordicbiotech.com/img/File/Comp Pres 2014/Autifony-session 1.pdf
http://www.anglonordicbiotech.com/img/File/Comp Pres 2014/Autifony-session 1.pdf
A good point. Many of these people are inundated with calls and emails from tinnitus patients. They are fully aware that people are suffering, and they are pursuing what they can with the science they have as quickly as regulatory agencies in the various countries are allowing them to. It is encouraging to see real money put in to startups these days though, 10 years ago none of this really existed.
- Jul 21, 2013
- 842
- Tinnitus Since
- 01/2013
- Cause of Tinnitus
- Acoustic trauma from headphones
Reducing the perception and annoyance.. Meaning lowering the T volume making it less annoying?
- Jul 21, 2013
- 842
- Tinnitus Since
- 01/2013
- Cause of Tinnitus
- Acoustic trauma from headphones
Yep.
Like they mention in the presentation, the only way to hear tinnitus is if your brain perceives it. For most people, even with damaged hair cells, the signal never reaches the brain, thus, they never perceive the sound. The drug targets the mechanism that isn't functioning up to snuff, and will lower the volume of the tinnitus perceived by regulating the Kv3 ion channels that "control the activity of key neural elements." Apparently, these guys are supposed to prevent you from hearing signals if you damage your hearing, but in some of us, they're not as strong. This drug is supposed to amp them up so they catch the signal and prevent it from getting to the brain. That would stop the tinnitus.
Oh shit i get it!!!! Now im more excited too!!! Thanks for explainin that to mee! 
Yep.
Like they mention in the presentation, the only way to hear tinnitus is if your brain perceives it. For most people, even with damaged hair cells, the signal never reaches the brain, thus, they never perceive the sound. The drug targets the mechanism that isn't functioning up to snuff, and will lower the volume of the tinnitus perceived by regulating the Kv3 ion channels that "control the activity of key neural elements." Apparently, these guys are supposed to prevent you from hearing signals if you damage your hearing, but in some of us, they're not as strong. This drug is supposed to amp them up so they catch the signal and prevent it from getting to the brain. That would stop the tinnitus.
Know what i mean though? What do you think? You think its really like concrete stuck in our brain and no way to escape? Just sounds ridiculous.. Theres always a way to figure shit out and it seems like there thinkin this may break the "chronic" cycle rather then acute cause there soo "different" bs.Now you're catching on folks
In my opinion the memory thing is total bullshit. If Autifony works, it will work on any chronicity.
There was a poster on the other forum who brought up an old post from 2002.
It was a post by Ron Harner. An American church minister who was featured in the tinnitus movie - The Devil's Symphony - its on Youtube I think.
Anyways here is the post- I bolded an important fact.
Re: Neurotologist (aka otoneurologist )
09/03/02 4:57 PM
May God's Grace and Peace be with each reader of this post.
Hi Sonny,
I have had a screaming case of pusatile tinnitus since 1984 when it came on me in a moment of time in the most peaceful of settings...while wading the Alllegheny River fishing for bass.
I saw my first "Neurotologist" at the University Hospital of North Carolina at Chapel Hill in the Fall of 1992. The doctors name was Pillsbury and he was the most compasionate and understanding doctor that I had ever met up until that time.
It is really difficult me for me to express how tormenting my tinnitus was at the time, but, even though I am a retired minister, it pains me to say that there was not a day that went by that I didn't contemplate putting a gun to by head and ending it all. This was the state of mind that Dr. Pillsbury found me in on my first visit to him.
After taking all the necessary tests, he gave me a 5cc injection of 2 percent lidocaine directly into a major vein in my right arm. As he was slowly depressing the plunger on the syringe, it was like a rheostat was slowing deminishing the roaring of my "T" and then absolute silence for the first time in 8 years. I began to weep and my wife, who was with me and saw the look of peace on my face, began to weep with me. It was like a miracle took place in my life. Silence, absolute silence.
Doctor Pillsbury was quick to tell me that it may not last long and unfortunately, it did not. By the time that I got back to my car the siren in my head had begun to scream at full volume once again. However, that one shot of lidocaine gave me an idea that I discussed with other doctors and the bottom line is that: what I was able to accomplish on my own got me through some of the toughest days of my life.
I just wish that there was a doctor Pillsbury here in Florida where I live now.
Sincerely yours,
Ron Harner
There was a poster on the other forum who brought up an old post from 2002.
It was a post by Ron Harner. An American church minister who was featured in the tinnitus movie - The Devil's Symphony - its on Youtube I think.
Anyways here is the post- I bolded an important fact.
Re: Neurotologist (aka otoneurologist )
09/03/02 4:57 PM
May God's Grace and Peace be with each reader of this post.
Hi Sonny,
I have had a screaming case of pusatile tinnitus since 1984 when it came on me in a moment of time in the most peaceful of settings...while wading the Alllegheny River fishing for bass.
I saw my first "Neurotologist" at the University Hospital of North Carolina at Chapel Hill in the Fall of 1992. The doctors name was Pillsbury and he was the most compasionate and understanding doctor that I had ever met up until that time.
It is really difficult me for me to express how tormenting my tinnitus was at the time, but, even though I am a retired minister, it pains me to say that there was not a day that went by that I didn't contemplate putting a gun to by head and ending it all. This was the state of mind that Dr. Pillsbury found me in on my first visit to him.
After taking all the necessary tests, he gave me a 5cc injection of 2 percent lidocaine directly into a major vein in my right arm. As he was slowly depressing the plunger on the syringe, it was like a rheostat was slowing deminishing the roaring of my "T" and then absolute silence for the first time in 8 years. I began to weep and my wife, who was with me and saw the look of peace on my face, began to weep with me. It was like a miracle took place in my life. Silence, absolute silence.
Doctor Pillsbury was quick to tell me that it may not last long and unfortunately, it did not. By the time that I got back to my car the siren in my head had begun to scream at full volume once again. However, that one shot of lidocaine gave me an idea that I discussed with other doctors and the bottom line is that: what I was able to accomplish on my own got me through some of the toughest days of my life.
I just wish that there was a doctor Pillsbury here in Florida where I live now.
Sincerely yours,
Ron Harner
And isn't pulsatile T different to noise T as pulsatile is more to do with blood flow??
On the Autifony PowerPoint presentation they say that it is the Kv3 ion channels that are not working properly in T sufferers, That would explain why not everyone with hearing loss perceives T when working properly it stops the bad signals on returning to the brain in the form of T, if I may put it in layman's terms! lol
That seems to be the theory they are working on anyways and by the looks, it is a theory that all the evidence seems to suggest!
All the evidence suggests that the memory thing is just BS!
Rich
On the Autifony PowerPoint presentation they say that it is the Kv3 ion channels that are not working properly in T sufferers, That would explain why not everyone with hearing loss perceives T when working properly it stops the bad signals on returning to the brain in the form of T, if I may put it in layman's terms! lol
That seems to be the theory they are working on anyways and by the looks, it is a theory that all the evidence seems to suggest!
All the evidence suggests that the memory thing is just BS!
Rich
Yes its true, but again Kv7 channels aren't auditory as far as I know.
Lidocaine may indirectly modulate kv3 channels, hence working in some and not others.
I hope Autifony will be much more effective.
Ron's tinnitus wasn't blood flow because lidocaine would have no effect if it were.
In the video The Devil's symphony he describes his tinnitus as continuous, so it may have changed over the years.
@Erlend @dan
Yes its true, but again Kv7 channels aren't auditory as far as I know.
Lidocaine may indirectly modulate kv3 channels, hence working in some and not others.
I hope Autifony will be much more effective.
Ron's tinnitus wasn't blood flow because lidocaine would have no effect if it were.
In the video The Devil's symphony he describes his tinnitus as continuous, so it may have changed over the years.
Yes its true, but again Kv7 channels aren't auditory as far as I know.
Lidocaine may indirectly modulate kv3 channels, hence working in some and not others.
I hope Autifony will be much more effective.
Ron's tinnitus wasn't blood flow because lidocaine would have no effect if it were.
In the video The Devil's symphony he describes his tinnitus as continuous, so it may have changed over the years.
by the way lidocaine is a Kv7 potassium channel modulator - do the math....
...Kv7 channels aren't auditory as far as I know.
Lidocaine may indirectly modulate kv3 channels (Autifony's target), hence working in some and not others
Now you're catching on folks
wow Dan, you get a Nobel prize for bringing this connection to our attention.
Lidocaine isn't just another tinnitus treatment. Its the closest we've come to the holy grail.
No matter how transient, it has hit the OFF-SWITCH in 60% of tinnitus patients.
Remember how Ron Harner wept.
It's the closest we've come to a sorcerer's stone, that alchemical substance which transmutes lead into gold, or in our case, neuronal symphonies of tinnitus into Elysian silence.
Lidocaine has been administered by intravenous infusion, so debate has raged as to where lidocaine may be working its temporary magic. Is it the cochlea, cochlear nerve, or deeper within the central auditory pathways
where Autifony struts its stuff?
In 2005, a useful study decided to treat tinnitus patients who had undergone translabyrinthine excision of a vestibular schwannoma (benign growth, often known as acoustic neuroma)
Here it is: http://www.ncbi.nlm.nih.gov/pubmed/15793400
The inhibitory effect of intravenous lidocaine infusion on tinnitus after translabyrinthine removal of vestibular schwannoma: a double-blind, placebo-controlled, crossover study.
The study concluded "The site of action of lidocaine in this instance must be in the central auditory pathway, as the cochlear and vestibular nerves are sectioned (destroyed) during surgery, and this finding has important implications for the task of identifying other agents that will have a similar tinnitus-inhibiting effect."
Ladies and gentlemen, I give you Autifony.
And what i like about Autifony (well, AUT00063 to be precise) is that it truly aims to target
CHRONIC tinnitus. It's objective is to correct and cure, unlike many suggested drugs
(eg furosemide) which only aim to be preventative during a brief early-window acute stage.
Damn autifony really might have something real good.. I would totally flip out and like go nuts if once there trials done that they say like 90 % of people got full or more then half reductions. And since this is a pill you take everyday maybe it will build in our systems and the longer your on it, the longer it works! Deff have hope on this tho, i just want people with severe T that affects them like crazy to get bigass reductions!!!!------ and is it also true that they hope it provides some kind of protection against hearing damage also? How awsome would it be to take a pill for T and it also protects your hearing along.
"Deff have hope on this tho, i just want people with severe T that affects them like crazy to get bigass reductions!!!!"
How noble and thoughtful of you to say this- Thank you.
How noble and thoughtful of you to say this- Thank you.
"Here it is: http://www.ncbi.nlm.nih.gov/pubmed/15793400
The inhibitory effect of intravenous lidocaine infusion on tinnitus after translabyrinthine removal of vestibular schwannoma: a double-blind, placebo-controlled, crossover study.
The study concluded "The site of action of lidocaine in this instance must be in the central auditory pathway, as the cochlear and vestibular nerves are sectioned (destroyed) during surgery, and this finding has important implications for the task of identifying other agents that will have a similar tinnitus-inhibiting effect."
Ladies and gentlemen, I give you Autifony."
Winner!!!
Well done my friend and co-Nobel Prize recipient.
The inhibitory effect of intravenous lidocaine infusion on tinnitus after translabyrinthine removal of vestibular schwannoma: a double-blind, placebo-controlled, crossover study.
The study concluded "The site of action of lidocaine in this instance must be in the central auditory pathway, as the cochlear and vestibular nerves are sectioned (destroyed) during surgery, and this finding has important implications for the task of identifying other agents that will have a similar tinnitus-inhibiting effect."
Ladies and gentlemen, I give you Autifony."
Winner!!!
Well done my friend and co-Nobel Prize recipient.
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