Autifony Therapeutics Phase II Study for AUT00063, for the Treatment of Hearing Loss and Tinnitus

[Danny Boy]

There's such a lot of drugs on the market that are prescribed off label, if AUT turns out to have a positive effect on T as well as the primary indication I would hope a doctor would prescribe it off label.
Yes, I think we will all be watching SF0034 very closely now Danny Boy ! If only the process didn't take so goddamn long but if shows good results as it goes through the stages of trials at least we will have some hope again and that will make the wait more bearable. Fingers crossed for SF0034 now.

I think we will be able to get it 0ff- label, if not there's always Spain. Gotta love Spain. Spanish eyes? More like Spanish drugs.

 

[dan]

I still have hope for QUIET-2.

 

[Blackbird26]

I think we will be able to get it 0ff- label, if not there's always Spain. Gotta love Spain. Spanish eyes? More like Spanish drugs.

Don't you mean Spanish fly?

 

[Danny Boy]

I still have hope for QUIET-2.

Well, we can hope they can make some changes... Heck, make a KV7 modulator.

 

[RaZaH]

@Mikey Cliff
Dont know how to break this to you but you were not alone fighting the world war.
But yeah ...of course you are "the leaders of the free world" freedohm and all that crap. USA USA !

 

[Dubbyaman]

Lets all jump back in time and FU##ING GOOGLE TINNITUS!!!!!!!!

 

[OnceUponaTime]

Dont know how to break this to you but you were not alone fighting the world war.

Buff history here. Lets not go there. We all know how many thousands of American soldiers (my uncle included) died at the front lines on the beaches or Normandy. (Utah, Omaha, Juno, Gold and Sword.) to name some.. Yes Great Britain and Canada and USA fought together. At the time Great Britain lost France and was under-siege .. ugly battle for all involved. .... ANYWAYS........Lets get back to the subject... as it pertains.

 

[RaZaH]

And Russians and you could argue that they are the ones that really held back the Nazis.

 

[OnceUponaTime]

On "their end" they did, they fought tremendously to defend themselves... They did nothing for France. And that's the end of my comments on this subject unless you want to talk it on PM's ...as I said, I do enjoy history tremendously especially WWI and WWII... (You should see my bookshelves! ) But that's conversation for a history forum... although discussing it makes me forget about T!!!! So I guess that is good. Picking my brain!

 

[RaZaH]

Im a WWI and WWII buff as well , I guess I do have a different perspective then a lot of "popular" history.
But yeah..back on topic.

 

[Sailboardman]

Forget about WW1 and WW2, where's everybody stand on WW3? You know, the next "Big One!" };-)

 

[Danny Boy]

Thats a bold statement to not back up with any facts.

More like Russia...

 

[Danny Boy]

Forget about WW1 and WW2, where's everybody stand on WW3? You know, the next "Big One!" };-)

I'm in WW3; it's called tinnitus lol

 

[Sailboardman]

I'm in WW3; it's called tinnitus lol

Thought you were cured with Trobalt & Keppra?

 

[Danny Boy]

Thought you were cured with Trobalt & Keppra?

Well, not so, it came back...But I took some more trobalt and it vanished. So god knows?

 

[Sailboardman]

Well, not so, it came back...But I took some more trobalt and it vanished. So god knows?

Guess you have to stay on Trobalt then? Considering there aren't many more choices left.

 

[Danny Boy]

Guess you have to stay on Trobalt then? Considering there aren't many more choices left.

I know...It's a sad life, very sad...But we must sail onward to SF! Shipshape and Bristol fashion ^_^

 

[Joan A.]

Hi all and forgive my ignorance;

i have received an email by this forum few days ago and even on the main page there is a comunication about the failure of this drug. My question would be; how is possible to establish that a drug, so new and in developement, have already failed?
how do scientists to have this certainty after such a short time ? thx

 

[erik]

Hi all and forgive my ignorance;

i have received an email by this forum few days ago and even on the main page there is a comunication about the failure of this drug. My question would be; how is possible to establish that a drug, so new and in developement, have already failed?
how do scientists to have this certainty after such a short time ? thx

Basically it came down to people testing and found that it didn't work on people

 

[Joan A.]

Thank You @erik . I don't have the possibility to connect and watch more news. I remained at the point that they were enrolling suffers because it was promising. It is a punch in the stomach for me because even if it was not imminent but it sound more better than the prescription of cipralex that i got in those days by my ent.

p.s. I'm doing the trt retraining therapy by more than 2 years and now... ironically i have developed another tinnitus on the right side! really really disappointed

thank you

 

[Hotspur]

Hi guys,just thought id let you know i find out which pill i got in March 2016

 

[Jay_Dee63]

Hi guys,just thought id let you know i find out which pill i got in March 2016

They won't tell you until another 5 months?

 

[jeannie]

I still think this pill would have helped at least some of us on here...we didn't stand a fighting chance ...alot of talk before about hidden hearing loss...so if the trial for that isn't cancelled and goes to market ,wonder if we will have to be 60 to get the pill,?maybe once the loss is better the tinnitus will get better!!!!!

 

[swc5150]

Just venting out loud, but it sure would be nice if the powers that be would allow people in desperate need to try a medication before it's officially approved. We have states in the US that allow Dr. assisted suicide, so why not allow one try a med like Aut or SF, if one shows enough desperation? We have numerous people in our T community who either commit suicide, or seriously contemplate it, so what's the harm in letting some try an experimental med, as long as they indemnify the manufacturer? I'd risk trying Aut, at a higher dose than 800mg, and for a longer duration perhaps. Sure, it may not work, but the rats received a higher dose than the trial members. Too much litigation and gov oversight/control IMHO. In fairness, there are some terminal patients who get to receive experimental meds in the US, I just wish that program would be expanded for people like us.

 

[dan]

In fairness, there are some terminal patients who get to receive experimental meds in the US, I just wish that program would be expanded for people like us.

Because technically we arent immediately dying from tinnitus...and they dont give a @#$% about complications from tinnitus suffering, i.e. if a person ideates suicide on a daily basis for 10 years, what do you think is happening to his insides?

 

[jeannie]

If they approve it for hearing loss,then wouldn't some people on here be able to get it at there doctor if they have loss?
If the hearing loss is made better with it then so would the tinnitus?!

 

[swc5150]

Because technically we arent immediately dying from tinnitus...and they dont give a @#$% about complications from tinnitus suffering, i.e. if a person ideates suicide on a daily basis for 10 years, what do you think is happening to his insides?

I agree with you 100%. Sucks

 

[jeff W]

Er, this is a pretty bold and controversial statement; do you have some evidence/research/whatever to back it up? Pharma profits are at an all time high, and it's pretty easy to come up with a list of 10 drugs from the last 10 years that have been wildly profitable. Safety and efficiency is a different story, and there are perils here, but the idea that the pharma model is failing because of an inability to profit seems... dubious.

Again, this is a sweeping and pretty controversial statement; why do you feel this way? Any treatment that is
* patentable
* effective
* somewhat safe

is going to thrive in the current model.


There are lots of things in the future that might make existing technologies obsolete; however, as I have said repeatadly, drug development is really in its infancy, it's only been within the past few decades that we have understood to some extent how transmitter and transporter systems work, and had the ability to start to design novel agents that target specific physical structures. So, I think saying that the party is already over, would have been like calling the automotive industry a failure right as the Ford Model T was approaching scale production...



Yes, I am well aware of the tinfoil-hat paranoia around the hearing aid industry (whose total profits are less than the largest single drug companies). Why is this relevant here? Do you have some brand new evidence that there's a vast cabal of shadowy hearing aid salesmen who are working in collusion with Autifony to suppress their results?

Lol.

They have been promising effective treatments using the model you describe above for a long time. Again, the capitalist approach to drug discovery is a very good business model but not very good for the sufferer.
Excluding preventative measures, I think expecting a pill to reverse tinnitus is foolish.
A ceiling has already been reached in what can be done with chemical intervention as evidenced buy the enormous amount of money poured into trials (such as this) and the disturbingly poor yield, and that is why science is shifting to the study of the stem cell.

As for the tinfoil hat stuff, who do you think invests into these ventures? These people have inside information, is it that much of a jump to imagine they place their financial interests (often tied to long term portfolios) ahead of furthering the science? This is very similar to the SSRI situation, its not an exact science, and they are pissing away money on mickey mouse drug trials wasting time. I don't have any faith in pharma, I anxiously wait to stand corrected, although I might be standing for while. My worry is our generation will pause their suspicion into these drug companies and we will all suffer as a result.

Hopefully whoever was in charge of this trial gets the bullet. That at least would be progress.

 

[jeff W]

...Agreed, and which is what I wrote a couple of days ago:

Listen... the results were poor, and, furthermore the science from the pre-clinical studies was perhaps based on flawed assumptions:

• Wrongly simulated tinnitus in the animal models (i.e. method of induction of tinnitus is important)
• Startle reflex GAP detection model for screening of tinnitus
• Chronicity

I don't have insights of the trial itself, and so, the above is just speculation on my part, but I have been corresponding with background sources in the past 4 to 5 days...

In addition, the following journal (see attachment) states that (see underlined sections):

attheedgeofscience
15/OCT/2015.

Thanks for that second paper, I had not given that serious consideration. As the old expression goes a millions zero is still nothing.

 

[jeff W]

What dos the hearing aid industry have to do with securing a possible cure or relief of Tinnitus?
Hearing aids and their effect for tinnitus are rare. A huge percentage of those struck with T have hearing that is acceptable and or fine. I have a small dip at 8,000. If the Hearing aid industry is that ruthless may those who run the industry rot in hell. I firmly believe that there is greed involved regarding politics and industry.

Cellular repair of the ear will virtually eradicate the need for prosthetic devices. They are well aware of this.