if autifony will succeed in his second trial, many of hearing compagnies go out of business
stop making the walk crochs ? please
Autifony Therapeutics Phase II Study for AUT00063, for the Treatment of Hearing Loss and Tinnitus
- Thread starter attheedgeofscience
- Start date
if autifony will succeed in his second trial, many of hearing compagnies go out of business
stop making the walk crochs ? please
@tomm and @ChrisC I'm so glad to hear I'm not the only one plugging up down there religiously. This city really is louder than Australia - on my main street an ambulance/police car goes by about every 10 minutes so I've taken to plugging whenever I leave the house!
@James White thanks for clearing up the confusion - definitely a wombat. Sadly not mine.
I've been offered an initial appointment at the Birmingham clinic (still waiting on hearing back from the London clinic). It will not be til mid Feb and I would need to pass (well, fail : ) as per their requirements ) the hearing test. I'm pretty sure I'm a bit deaf from years of clubbing but I'm not sure I'll be deaf enough. Let's hope so. Of course I'll keep everyone updated.
@preslys I am an Australian but I'm on a student visa and with NHS - as long as you're on NHS and you're here for long enough you're ok I think
@James White thanks for clearing up the confusion - definitely a wombat. Sadly not mine.
I've been offered an initial appointment at the Birmingham clinic (still waiting on hearing back from the London clinic). It will not be til mid Feb and I would need to pass (well, fail : ) as per their requirements ) the hearing test. I'm pretty sure I'm a bit deaf from years of clubbing but I'm not sure I'll be deaf enough. Let's hope so. Of course I'll keep everyone updated.
@preslys I am an Australian but I'm on a student visa and with NHS - as long as you're on NHS and you're here for long enough you're ok I think
I believe my T is caused due high temperature water entering my left ear. Therefore my inner middle ear may have physical damage, though I don't know. Should I assume that since the damage to my ear is possibly physical that drug treatments like AUT00063 would be ineffective since they target the brain?
Member- Jul 21, 2013
- 842
- Tinnitus Since
- 01/2013
- Cause of Tinnitus
- Acoustic trauma from headphones
- Oct 22, 2014
- 240
- 40
- Tinnitus Since
- 10/2014
- Cause of Tinnitus
- Acoustic trauma (club drumming)
UCL came back to me.
UK people can call Nottingham for a telephone pre-screening, prior to a GP referral and proper screening.
As far as I can tell, Nottingham can screen you for all UK sites and then tell you who to contact closest to you.
Call 0115 823 2600
between 1000 and 1500.
Ask to register for a telephone screening for the QUIET-1 trial.
UK people can call Nottingham for a telephone pre-screening, prior to a GP referral and proper screening.
As far as I can tell, Nottingham can screen you for all UK sites and then tell you who to contact closest to you.
Call 0115 823 2600
between 1000 and 1500.
Ask to register for a telephone screening for the QUIET-1 trial.
- Oct 22, 2014
- 240
- 40
- Tinnitus Since
- 10/2014
- Cause of Tinnitus
- Acoustic trauma (club drumming)
Confirmation of the hearing loss requirement.
"The trial requires a participant to have an average hearing loss of 20-60db across the frequencies between 250Hz and 4000Hz."
If your audiogram is perfect at those low frequencies, you'll have to hold on.
"The trial requires a participant to have an average hearing loss of 20-60db across the frequencies between 250Hz and 4000Hz."
If your audiogram is perfect at those low frequencies, you'll have to hold on.
well that rules me out then for autifony cos mine only shows a hearing loss at 8Hz...and that is if it is accurate cos i have had two hearing tests with different results
i thought this was an average though. so as long as you have losses in the higher frequencies high enough to average it to 20dB, you are good.
also wanted to point out that it is possible to game your audiogram
Awesome! I hope nothing but the best for you. From the Phase I trial, it sounds like the side effects were pretty mild, so hopefully it will be an easy process. Please update us when you can as we will all be looking forward to hearing about it!
I've now got my initial screening appointment confirmed for Monday 12th January. I don't think it is likely that I will meet the hearing loss requirement even though I have some hearing loss in the higher frequencies. My hearing in mid-range frequencies is about normal for my age and I'm pretty sure that I don't have have an average hearing loss of 20-60db between 250Hz and 4000Hz. Therefore, I'm thinking that I probably won't get on to the trial but it's still worth a try.
Great news! I think I speak for everyone here when I say we hope you find relief. Please update us if you can.
Before tinnitus, I thought my wife and daughter had really good hearing and I was normal. My hearing went down a bit with the event that gave me tinnitus, but not that much, and it turns out I would qualify with flying colors. Hearing, like silence, is relative, so you never know without testing.
@Shaun Yay!
This article was posted in another thread but it mentions Autifony:
http://www.nytimes.com/2015/01/10/b...ted-attract-drug-makers-attention-.html?&_r=1
"Autifony Therapeutics is conducting early trials of a daily pill aimed not at hair cells but at helping the brain better interpret signals from the auditory nerve."
Now they mention "daily pill". How can we interpret this? Does this indicate that drug will be something you would have to take everyday for a lifetime?
http://www.nytimes.com/2015/01/10/b...ted-attract-drug-makers-attention-.html?&_r=1
"Autifony Therapeutics is conducting early trials of a daily pill aimed not at hair cells but at helping the brain better interpret signals from the auditory nerve."
Now they mention "daily pill". How can we interpret this? Does this indicate that drug will be something you would have to take everyday for a lifetime?
@Shaun and @PhilB great news. hope you both get the active treatment.
in case it is of interest to anyone i've attached the participant info sheet i got sent from autifony. hopefully you can read it. i'm eligible to come in for a screening appointment, here's hoping my hearing is worse than i thought : )
i didn't realise that half of participants get placebo - so just a head's up for anyone who didn't realise that either. if you get the placebo, you don't get active treatment afterwards
in case it is of interest to anyone i've attached the participant info sheet i got sent from autifony. hopefully you can read it. i'm eligible to come in for a screening appointment, here's hoping my hearing is worse than i thought : )
i didn't realise that half of participants get placebo - so just a head's up for anyone who didn't realise that either. if you get the placebo, you don't get active treatment afterwards
Attachments
@2131e
Take that Wombat of yours and see if you can get on the trial then. I think you qualify as long as you are a resident there? I'm not sure though.
I wouldn't take too much notice of that, usually article writers have a habit of not reporting word for word and sometimes inserting their own interpretation of it.
Autofony have stated that they believe it will be a course and not a lifetime dose!
What information exactly are you referring?
Autofony's website and reading all the research that has been undertaken by them, remember this research has been years in the making!
Because they tested the mice months after administering the initial treatment and Tinnitus had not returned!
I don't recall reading this, Rich, can you point it out?
To anybody who has not had experience with this: taking a pill everyday is no big deal. I took Propecia for a decade to hold on to my hair (which, after 10 months off Propecia, has not gone anywhere...go figure) and the biggest hassle was swinging by the pharmacy once a month. Which was no hassle at all. Now! I realize the main question on everybody's minds is, will health insurance cover it? I don't see why not. Propecia was on me, since hair is not a medical necessity, but a tinnitus treatment/cure? It would be criminal - by which I mean we should bring a class action lawsuit - if companies denied that benefit. This from the guy who got health insurance coverage for Potiga. I love my health insurance.
Oh mate, I'm going to have to look for it, I was just going by memory of reading about the research they did.
I will try and find it, it was like 8 month's or so ago when I read it!
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