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Autifony Therapeutics Phase II Study for AUT00063, for the Treatment of Hearing Loss and Tinnitus

Funding from charity for new treatments to silence tinnitus
Posted by ap507 at Feb 04, 2015 09:54 AM | Permalink
University of Leicester involved in new project announced during Tinnitus Awareness Week
Issued by the University of Leicester Press Office on 4 February 2015

Today, to mark Tinnitus Awareness Week (2 – 8 February), UK charity Action on Hearing Loss (formerly RNID) announces a major investment to fund a new study at Newcastle University, and involving the University of Leicester, which aims to accelerate the development of future tinnitus treatments.

Six million people in the UK are affected by tinnitus every day – ranging from a light buzzing to a constant roar in the ears and head – with 600,000 seriously affected by the condition, which can have a detrimental effect on quality of life including bouts of anxiety, difficulties socialising and problems sleeping or being able to concentrate at work.

The three year, £300,000 project will be led by Dr Mark Cunningham at Newcastle University and will involve researchers at the University of Leicester and the biotechnology company Autifony Therapeutics Ltd, who are currently conducting a clinical trial of a drug for tinnitus.

The pioneering research aims to bridge the gap between promising laboratory research discoveries and testing new medicines in tinnitus patients.

Dr Martine Hamann is Lecturer in Neurosciencesat the University of LeicesterDepartment of Cell Physiology and Pharmacology. She said: "At the University Leicester, we will be performing tinnitus screening using reliable paradigms and novel therapeutic treatments will then be tested at University of Newcastle."

Lead researcher, Dr Mark Cunningham said: "The focus of this project is to see if we can use electrical waves in one of the hearing centres of the brain to measure tinnitus both to discover if the therapy developed by Autifony is working and how it is having its effect. The use of an animal model of tinnitus will allow us to investigate brain wave activity in the hearing centres and develop a biological measure which can be used on patients in the clinic as well as future research."

Dr Ralph Holme, Head of Biomedical Research at charity Action on Hearing Loss, said: "Tinnitus is a debilitating condition for which there is no cure, but real progress is being made towards understanding the mechanisms behind the condition, giving us hope that effective treatments can be found. Currently the search for new treatments is being slowed down because it is very hard to know if the effects of potential new treatments seen in animal studies are relevant to tinnitus in humans. Our new project has the potential to overcome this barrier, speeding up the development of urgently needed treatments."

Action on Hearing Loss runs the world's largest donor-supported hearing research programme, dedicated to funding research into better treatments and cures for hearing loss and tinnitus.
 
measure tinnitus both to discover if the therapy developed by Autifony is working and how it is having its effect.

This is good to hear, but as far as Autifony is concerned, somewhat premature when their new drug has only just started to be trialled.

I would have thought they would wait to see the results in July to see if they were on the right path than trying anything different.

Surely, the measure of whether the drug is working or not is the patient experiences a reduction in tinnitus or a cessation?
 
This is good to hear, but as far as Autifony is concerned, somewhat premature when their new drug has only just started to be trialled.

I would have thought they would wait to see the results in July to see if they were on the right path than trying anything different.

Surely, the measure of whether the drug is working or not is the patient experiences a reduction in tinnitus or a cessation?
If you can measure the results using a machine, you don't need to rely on the unreliable values people give. 1 person's 6 is another person's 10 etc.

If the signal went down 20% as measured by a machine you have reliable indicator of just how much effect you're having, and if you can objectively measure your results more people are likely to work on the problem.
 
It appears as though they are giving trialees EEG exams before and after to see the effect of the treatment on reducing hyperactive tinnitus causing brainwaves.
This is the same system that world class neurological centers like the hifu centre in Switzerland uses or deep brain stimulation procedures for tinnitus. They have observed that after invasive brain treatment, brainwaves begin to normalize and come down to normal levels, which in turn reduces the tinnitus loudness and annoyance. The thing is that sometimes even though the brainwaves have returned to normal, the patient still searches for the tinnitus and finds it, hence amplifying the perception. This is now called psychogenic tinnitus - brainwaves have more or less normalized, yet tinnitus can still be heard. In this case couneling and psychotherapy is needed.
Reading EEG scans will tell if the treatment is having a THERAPEUTIC effect on the brain in general - an effect which the patient might not immediately notice.
 
"Dr Ralph Holme, Head of Biomedical Research at charity Action on Hearing Loss, said: "Tinnitus is a debilitating condition for which there is no cure, but real progress is being made towards understanding the mechanisms behind the condition, giving us hope that effective treatments can be found."

Can anyone explain to me? What is the real progress...? So does anyone really know the "mechanisms behind the condition"? I mean, I am an IT troubleshooter. And as soon as we found the root cause, the solution is found quickly. Most of the time, 95% is finding and understanding the root cause, the rest is easy. Of course, human brains are not computers. I am just curious if there is really someone who understands where T is coming from.
 
"Dr Ralph Holme, Head of Biomedical Research at charity Action on Hearing Loss, said: "Tinnitus is a debilitating condition for which there is no cure, but real progress is being made towards understanding the mechanisms behind the condition, giving us hope that effective treatments can be found."

Can anyone explain to me? What is the real progress...? So does anyone really know the "mechanisms behind the condition"? I mean, I am an IT troubleshooter. And as soon as we found the root cause, the solution is found quickly. Most of the time, 95% is finding and understanding the root cause, the rest is easy. Of course, human brains are not computers. I am just curious if there is really someone who understands where T is coming from.

Hahaah sorry man but this made me laugh straight for some minutes and you are damn right.
 
Yes. Unfortunately it is not funny, but simply sad.
I sometimes think that it is more about getting funding than knowing anything about this BS in our head.
Lads check out the Mutebutton Thread.

They emailed me today claiming on average a 42% reduction in Tinnitus loudness after 10 weeks of using the device for 30 Mins a day.

The Irish have done it!!

This is nothing new check my contributions to the mutebutton thread or Q to Doc Nagler

https://www.tinnitustalk.com/threads/am-101-aftermath-mutebutton-future.8091/

U can laugh at me 2 at the moment to counter this nasty spike stuffing myself with Goji Berries

PS: I will rate your post as funny though, seems to be trending tonight in this topic
 
"Dr Ralph Holme, Head of Biomedical Research at charity Action on Hearing Loss, said: "Tinnitus is a debilitating condition for which there is no cure, but real progress is being made towards understanding the mechanisms behind the condition, giving us hope that effective treatments can be found."

Can anyone explain to me? What is the real progress...? So does anyone really know the "mechanisms behind the condition"? I mean, I am an IT troubleshooter. And as soon as we found the root cause, the solution is found quickly. Most of the time, 95% is finding and understanding the root cause, the rest is easy. Of course, human brains are not computers. I am just curious if there is really someone who understands where T is coming from.

the difference is that an IT problem is `man-made` ... Tinnitus is `god-made` .. who knows what that dude has been up to when he invented us?!
 
the difference is that an IT problem is `man-made` ... Tinnitus is `god-made` .. who knows what that dude has been up to when he invented us?!

Hahha that rating u handed out at previous rcp1 post: creative

hahaah soooo goodd jeeh this thread keeps me laughing.. i suppose that mail which came from mutebutton was a newsletter or a direct mail with as purpose to sell it!
That device better works
 
"Dr Ralph Holme, Head of Biomedical Research at charity Action on Hearing Loss, said: "Tinnitus is a debilitating condition for which there is no cure, but real progress is being made towards understanding the mechanisms behind the condition, giving us hope that effective treatments can be found."

Can anyone explain to me? What is the real progress...? So does anyone really know the "mechanisms behind the condition"? I mean, I am an IT troubleshooter. And as soon as we found the root cause, the solution is found quickly. Most of the time, 95% is finding and understanding the root cause, the rest is easy. Of course, human brains are not computers. I am just curious if there is really someone who understands where T is coming from.
lol I know what you mean man, I'm a software engineer and if I'm not figuring out how to fix bugs and understand/build the system better I'm out of a job. Some of these researchers.. just what the hell do they do all day? Play videogames on their iPads? Sheesh.
 
Can anyone explain to me? What is the real progress...?
Maybe if you think about it like - since the Heller and Bergman experiment in the 1950's, zero progress has been made for around 50 years. Then around 2010 we have new research of Auris, Autifony, Genvec, RTG research, hifu, brain stimulation, tinnitus brain mapping, and so on. Scientists have also said (I belive somebody here mentioned it) that they found a way of stopping tinnitus completely in animals, but the drug is too toxic for humans at this point.
 
lol I know what you mean man, I'm a software engineer and if I'm not figuring out how to fix bugs and understand/build the system better I'm out of a job. Some of these researchers.. just what the hell do they do all day? Play videogames on their iPads? Sheesh.

You can't just do debug.print on tinnitus, sorry lol
 
lol I know what you mean man, I'm a software engineer and if I'm not figuring out how to fix bugs and understand/build the system better I'm out of a job. Some of these researchers.. just what the hell do they do all day? Play videogames on their iPads? Sheesh.

I think most of them really have a motivation into finding a treatment for tinnitus. Here in France, research is absolutely respected, it's a very challenging field. I work with researchers as i'm an IT admin at University and while they are not working on medical research, they are still working very hard ! :)
 
I think most of them really have a motivation into finding a treatment for tinnitus. Here in France, research is absolutely respected, it's a very challenging field. I work with researchers as i'm an IT admin at University and while they are not working on medical research, they are still working very hard ! :)


I agree! My father was also a medical research, he worked almost 7/7 for more than 10 hours every day to find
ways to fix some deadly diseases. If you don't have the "researcher" in you, you wouldn't do this job.
In most cases it's underpaid and yes, time consumpting... but very interesting.
I also know researchers in the inner ear field and believe me, they work hard and very very seriouse.
We should be thankful, that there is more and more research in this field.
Ofcourse, it's a lot of trial and error, but if it would be so easy, someone would have found a cure already.
 
So is this lady on Autifony?
If so it will be interesting to see if it helps her after having t for 14 years!
It is not clear from the article.
I guess if Autifony will help, we will see it here on the board very soon.
Unfortunately no one has yet reported that AUT00063 brought silence to him/her.
 
I guess if Autifony will help, we will see it here on the board very soon.
Unfortunately no one has yet reported that AUT00063 brought silence to him/her.

From all reports so far, it would seem, (hopefully), that the participants on this forum are receiving the placebo, I hope they are if there's no change in their T after the final dosing anyway!
 
found this scientific paper on the Kv3.1 channel modulation. It`s from 2003 and discusses the significance of these potassium channels for maintaining timing and firing frequency of the neurons in the auditory brainstem.

It seems like all the pieces of the puzzle come together in AUTooo63. Suzanne Shores theory, Tinnitus being a brain thing rather than an ear thing ... well, we don`t know much more to be honest ... now we just need proof!

here is the paper, enjoy!

http://www.jneurosci.org/content/23/4/1133.full.pdf

(side note; notice how tinnitus isn`t mentioned once in the whole paper!)

and just to up the trust I add again this one as a reminder :)

http://www.autifonytherapeutics.com/publications/Turneretal2013-TRI_final.pdf
 

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