Autifony Therapeutics Phase II Study for AUT00063, for the Treatment of Hearing Loss and Tinnitus
- Thread starter attheedgeofscience
- Start date
Member
Don't worry to much about it they statisically are aware about some Fake people participating.
All this talk about fake people is odd...They will all have tinnitus.
Well, hopefully phase 3 isn't so strict....Also, maybe they'd have a follow-up treatment like AM-101.
Well, hopefully phase 3 isn't so strict....Also, maybe they'd have a follow-up treatment like AM-101.
Autifony will not improve pure tone threshholds from my understanding. Only repair/regeneration of hair cells will do that.
The drug is aimed at improving auditory processing with background noise and eliminating T, but it works deep in the brain, not in the cochlea.
There is no regeneration of any part of the cochlea with Autifony so I can't answer your q. on hyperacusis. I think hyperacusis involves inflammation in the cochlea and usually subsides within a few months (mine did). Treating T definitely will improve or eliminate hyperacusis. But nothing beats the biological cure that is on it's way!
Btw, This article really has the answer about ribbon synapse damage with recent noise induced T.
(http://www.sciencedaily.com/releases/2014/10/141020212308.htm)
http://www.medicalnewstoday.com/articles/284159.php
The drug is aimed at improving auditory processing with background noise and eliminating T, but it works deep in the brain, not in the cochlea.
There is no regeneration of any part of the cochlea with Autifony so I can't answer your q. on hyperacusis. I think hyperacusis involves inflammation in the cochlea and usually subsides within a few months (mine did). Treating T definitely will improve or eliminate hyperacusis. But nothing beats the biological cure that is on it's way!
Btw, This article really has the answer about ribbon synapse damage with recent noise induced T.
(http://www.sciencedaily.com/releases/2014/10/141020212308.htm)
http://www.medicalnewstoday.com/articles/284159.php
Because everyone on here believes people with non-tinnitus really wants it lol!
Plus there's a drug in development which is made aimed at regenerating hair cells. In-fact ENT's from hospitals said that Autifony's new drug will work better for tinnitus than age related hearing loss...So all this talk about the hearing loss component is foolish, if people get in and are cured/helped then we should be glad they got in. Tinnitus is horrible and if someone is on the verge of killing themselves they should be given this treatment.
I didn't search yet as I'm on my mobile device, but which drug is this that you speak of?
Important is that least T can be alleviated in some way by a drug.
Ok interesting article. Does anyone know of this development also will contribute in lowering T?
Nobody knows if restoring heir cells will stop tinnitus, it could stop the signal but we don't know? All we know is potassium channel modulators are the true new treatment for tinnitus.
My thoughts are similar, this is why I asked the question: How can Aut00063 drug repair hearing loss?
If tinnitus is interconnected with hearing loss (they occur at the same time) it would only be logical that an audiogram will be better if no tinnitus is present, hence the hearing loss tab to Autifony's label. However, it is also logical to assume that whatever positive results this Autifony drug may have for tinnitus and hearing loss (still think they are bound together) will only be temporary as no real repair to the damage will take place. Now this is only an assumption on my part, I will welcome a different opinion if there is any. (Perhaps Autifony helps with ribbon synapses?)
An interesting follow up was already mentioned here: https://www.tinnitustalk.com/threads/cochlear-implant-gene-therapy-regrowth-of-auditory-nerve.4476/
However they have removed the interesting link in which a discussion about the plus and cons of every treatment was discussed. I don't know if the cure is on its way. They just take too long. I am afraid there are parameters that may hinder such a development, although to slow down something so big you should provide with other alternatives, which just seems so difficult to accomplish. A hearing aid can hardly qualify if you get my meaning... The same goes for cochlear implants which destroys the cochlea beyond repair.
How long was it before your hyperacusis was gone? Mine is still there after 6 months and doesn't
seem to be going anywhere...
SteveToHeal
Member
More info from one of the centers:
We shall not know efficacy from ph II until year end.
Phase III work can then start to be planned - so not before next year, i'm afraid, and that depends upon results + securing funding.
We shall not know efficacy from ph II until year end.
Phase III work can then start to be planned - so not before next year, i'm afraid, and that depends upon results + securing funding.
undecided
Member
it must work. they may have tested it on humans before the trial. they must think it works to run a trial. trials are expensive...
Christian78
Member
- Dec 17, 2013
- 965
- Tinnitus Since
- (Sep 2013)
- Cause of Tinnitus
- progressive tinnitus, time of expiring in next 3-6 months
I have mainly been involved in highlighting research and new developments and also exposing dodgy treatments.
However I see advocacy as being the key requirement, as this drives everything else, and is a major shortfall. And this is were the strength of numbers can help. having spoken to research organisations, and researchers, they would welcome increased advocacy for tinnitus,
So is there a team set up for advocacy and if sowho is the contact?
Nick J.
Member
This newspaper artikle was just sent to me on facebook today!
Anybody knows anything about this??
Anybody knows anything about this??
What ? Have not heard of this , Autifony and a pill ? In 4 weeks , a cure . This is either huge or a massive misundersatnding or something ...wow..must say I am curious now.
FounderI moved your post from the LLLT thread here where it belongs, our current main Autifony thread.
You may also want to read this thread:
https://www.tinnitustalk.com/threads/autifony-q-a.8331/
Nick J.
Member
Yaa im not sure what to think of it.
This specific British newspaper is from what i seems to remember, not a paper u cant trust.
The bring up a lot of sensational stuff just to draw in readers.
But hey...some stories might be true!
I just wanted to throw it out there and hear some respondses in here...
This specific British newspaper is from what i seems to remember, not a paper u cant trust.
The bring up a lot of sensational stuff just to draw in readers.
But hey...some stories might be true!
I just wanted to throw it out there and hear some respondses in here...
Nick J.
Member
Its ok!
Im not good at talking in multiple threads! Gets to complicated for me. So i have a tendency to post everything in the same thread hehe.
But i will take a look at your link! Thx
That paper is a rag - dont believe it.
Headline says 'drug to end tinnitus hell' then rehashes what is essentialy old news about the trial.
There are quite a few papers in the Uk to be avoided if you want real news
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