Autifony Therapeutics Phase II Study for AUT00063, for the Treatment of Hearing Loss and Tinnitus
- Thread starter attheedgeofscience
- Start date
MemberIt might be a case of covert communication difficulties like in the film 'Where Eagles Dare'
"Broadsword calling Danny Boy, Broadsword calling Danny Boy, come in please....."
Lloyd Carter
Member
What is the difference betwee Retigabine/Trobalt and Autifony? And if Retigabine/Trobalt hasn't worked with many TT members, why would Autifony be any different? NOT trying to be negative, just curious.
Yo
you are new here welcome
read Retigabine thread and autifony thread then you will know what is the difference
you are new here welcome
read Retigabine thread and autifony thread then you will know what is the difference
Lloyd Carter
Member
Thank you so much for the quick reply and welcome, preslys. I was just wondering if someone that knows a lot (@Danny Boy for instance) could shed some light in a few sentences and let me know why Autifony might hold much more promise for us.
Firstly Trobalt has worked for many people. At least it has reduced the sound permanently.
Secondly Trobalt works on KV7 and KV3 channels in the brain. Autifony works only on the KV3 channels. Hence less scatter gun approach and less side effects.
That is it in a nutshell and hope it helps....by the way Trobalt was developed by the same person who developed Autifony drug.......so he knows what he is doing!
Lloyd Carter
Member
@amandine thanks so much! Helps a ton. My only other question would be, for our friends that Trobalt has not worked for, is there still hope that Autifony will? Side effects aside, wondering whether the way each drug works on the KV3 channels is significantly different. If not, theoretically, couldn't anyone try Trobalt and have an idea of whether Autifony will work? Because that would tell them whether working on the KV3 channels can reduce their sound? Thanks again for the response!
I imagine it's a dosage thing. For those that Trobolt didn't work for it maybe might have if they could increase the dosage enough but the sideffects are so severe if you go up in dose that much. With a "cleaner" drug such as Autifony seems to be you could probably go up in dose with less sideffects and then you might get relief. This is just speculation from my part though.
Autifony is gonna be focused just on KV3, with more precise targeting of Kv3, and as Silvio Sabo said diference also in dosage where the full strength of dosage will focused on Kv3. So I suppose that no matter if trobalt was not doing the job, Autifony may do. But just my opinion.
Yes i guess anyone can take it to try it out - but the side effects are scary
This is why I couldn't get on the Autifony trial....
"I've asked the Consultant to double check the audiogram you had here on 14/10/2014 and unfortunately you still don't fulfil the criteria. Your hearing is actually very good and the biggest loss you have is 15dB."
"I've asked the Consultant to double check the audiogram you had here on 14/10/2014 and unfortunately you still don't fulfil the criteria. Your hearing is actually very good and the biggest loss you have is 15dB."
AUT00063, AM-101 and VNS are covered in this recent article:
http://www.the-scientist.com/?articles.view/articleNo/43843/title/The-Sounds-of-Silence/
"Meanwhile, other researchers are developing therapies that target the brain to treat patients whose tinnitus has progressed to the auditory cortex. One strategy currently under investigation is the manipulation of the potassium channels found throughout the auditory pathway. "[Using] potassium channel modulators, the activity in the central auditory pathway can be changed," Langguth says.
U.K.-based Autifony Therapeutics began in 2011 as an outgrowth of GlaxoSmithKline's investigation of potassium channels in the auditory system. Autifony CEO Charles Large and his colleague Giuseppe Alvaro are focusing on the development of the previously unexamined Kv3 potassium channels, which exist throughout the brain and in high abundance on the auditory nerve and cortex, allowing the neurons to signal rapidly. After exposure to loud noises, these channels can be damaged and fail to properly conduct ions, making them an ideal drug target for the treatment of tinnitus.
Working with academic collaborators, Autifony researchers developed a small-molecule drug that enhances the function of the Kv3 channels. In rodent models, the drug reduced the spontaneous neural activity in the midbrain auditory system associated with tinnitus. "We're dampening down a spurious activity that is believed to give rise to the phantom perception," says Large. "We have a lot of confidence from our preclinical work that we should see some interesting effects in people with tinnitus."
Autifony researchers are currently recruiting patients for Phase 2 trials in the U.K. In contrast to Auris Medical's target patient population, Autifony focuses on people whose tinnitus is established in the brain and who have had the disorder for at least six months (but no more than 18 months). The treatment is currently taken as a daily oral pill for 28 days, although the length of the treatment course is still under investigation.
"Autifony is really quite unique in having a drug treatment that's been rationally designed around the idea that we can dampen down the hyperexcitability that we see in the nervous system," Large says."
http://www.the-scientist.com/?articles.view/articleNo/43843/title/The-Sounds-of-Silence/
"Meanwhile, other researchers are developing therapies that target the brain to treat patients whose tinnitus has progressed to the auditory cortex. One strategy currently under investigation is the manipulation of the potassium channels found throughout the auditory pathway. "[Using] potassium channel modulators, the activity in the central auditory pathway can be changed," Langguth says.
U.K.-based Autifony Therapeutics began in 2011 as an outgrowth of GlaxoSmithKline's investigation of potassium channels in the auditory system. Autifony CEO Charles Large and his colleague Giuseppe Alvaro are focusing on the development of the previously unexamined Kv3 potassium channels, which exist throughout the brain and in high abundance on the auditory nerve and cortex, allowing the neurons to signal rapidly. After exposure to loud noises, these channels can be damaged and fail to properly conduct ions, making them an ideal drug target for the treatment of tinnitus.
Working with academic collaborators, Autifony researchers developed a small-molecule drug that enhances the function of the Kv3 channels. In rodent models, the drug reduced the spontaneous neural activity in the midbrain auditory system associated with tinnitus. "We're dampening down a spurious activity that is believed to give rise to the phantom perception," says Large. "We have a lot of confidence from our preclinical work that we should see some interesting effects in people with tinnitus."
Autifony researchers are currently recruiting patients for Phase 2 trials in the U.K. In contrast to Auris Medical's target patient population, Autifony focuses on people whose tinnitus is established in the brain and who have had the disorder for at least six months (but no more than 18 months). The treatment is currently taken as a daily oral pill for 28 days, although the length of the treatment course is still under investigation.
"Autifony is really quite unique in having a drug treatment that's been rationally designed around the idea that we can dampen down the hyperexcitability that we see in the nervous system," Large says."
G
Guest57247683
Guest
Stated in the text in the link: For patients with chronic tinnitus beyond the 18-month window being targeted by Autifony, a third potential treatment is making its way through clinical trials. MicroTransponder's therapy is a riff on a decades-old treatment for epilepsy and depression called vagus-nerve stimulation.
- If Autifony AUT00063 drug is meant only for people within 18 months tinnitus?? So this is not for longer sufferers (more chronic?) Only then VNS for them?? This is then very sad. Or is the 6-18 months just perhaps for the trial criteria and the AUT could work also for longer sufferers?
What do you think?
- If Autifony AUT00063 drug is meant only for people within 18 months tinnitus?? So this is not for longer sufferers (more chronic?) Only then VNS for them?? This is then very sad. Or is the 6-18 months just perhaps for the trial criteria and the AUT could work also for longer sufferers?
What do you think?
I interpret it as they are only talking about the criterias for the clinical trials since Autifony themselves states that their compound is for chronic T. If autifony only targeted acute T, they wouldnt have the 6-18 months criteria in my opinion. They would've went with 0-3 or 0-6 months for best results. However, no one knows if it will work or not and no one knows when exactly T becomes chronic.
True...It'll be like AM-101 when it first started 3 months only. That's acute, then again...We have no clue how long the acute stages are.
Since Autifony's drug targets the brain, which is the final stage, and not the ear, which is the starting point, it should work just as well for people that have had it for 18 months as for those that have had it for 18 years. At least in theory.
- Jan 3, 2015
- 635
- Tinnitus Since
- 04/21/2014
- Cause of Tinnitus
- Sensorineural hearing loss right ear.
- Jan 3, 2015
- 635
- Tinnitus Since
- 04/21/2014
- Cause of Tinnitus
- Sensorineural hearing loss right ear.
Only asked, because some people here, may not be able to afford it, if it's at "designer drug" prices.
For me, I'd rather be homeless, if I could hear silence again!
For me, I'd rather be homeless, if I could hear silence again!
Any severe suffere would!hence your question was moot
By the way if thats your swimming pool, i think u will be fine lol
- Jan 3, 2015
- 635
- Tinnitus Since
- 04/21/2014
- Cause of Tinnitus
- Sensorineural hearing loss right ear.
Actually the question was about how much it would cost, if it works? Not moot at all. If some people can't afford it, they will not benefit from it. If it doesn't work, no one will.
Yes, my pool. Never use it now. I use to do 100 laps everyday and then chill and snooze on a float. There's just no way I can relax anymore, so it's used by my family only.
Yes, my pool. Never use it now. I use to do 100 laps everyday and then chill and snooze on a float. There's just no way I can relax anymore, so it's used by my family only.
Dubbyaman
Member
Ugh. This autumn?? The medical field just takes their sweet time don't they? I felt this way before T as well. I was listening to a guy on the radio one time and he was explaining how much better the world would be if we just took the millions and millions we spend on entertainment. The big football games, WWE, iphones, gaming etc etc and shifted it towards medicine.
What? The VNS study took place quite recently and this autumn is like now/soonish. I think that's pretty fast. Anyway, the VNS study has it's own thread. We're off topic.
Dubbyaman
Member
Oh wow. I stand corrected lol. For some reason I thought autumn was spring. But yeah, back on topic. I hope this drug works and hopefully we can see more success stories of those on trial between now and next year.
I thing talking about price if drug works is not needed, off topic, useless...But for sure in some parts of the world it would be to expensive for most of domestic population. As well, it is the same with other drugs that are new on the market and first for some condition.
Price will depend of length of treatment. If it will be a magic pill that cures in one month it will be for sure expensive month. But if there is need to take for a months for results, it will be more affordable (I mean on monthly base).
What I think if that would be very expensive, and if it really works WORKS, we should make some kind of found for severe suffers in undeveloped countries....but firstly, hopes that aut is gonna for for most of us
Price will depend of length of treatment. If it will be a magic pill that cures in one month it will be for sure expensive month. But if there is need to take for a months for results, it will be more affordable (I mean on monthly base).
What I think if that would be very expensive, and if it really works WORKS, we should make some kind of found for severe suffers in undeveloped countries....but firstly, hopes that aut is gonna for for most of us
In most European countries it will probably be covered by the health care system, if not the whole amount then at least a part of it. And even though it's not the best or loyal thing to say but the patent will expire at some point (I think it's 10-15 years or something like that) and then you will probably see companies producing the pills for pennys.
The Patent on Viagra expired not long ago and Viagra isn't that old. I think it came out in 1998.
noisebox
Member
- Jul 4, 2015
- 319
- Tinnitus Since
- 04/2012
- Cause of Tinnitus
- West End show. Came back 2015 vitamin D overdose prescribed
Can I add again, my reply said results end of this year. And the prof neuro otologist in Sheffield leading the study with Autiphony said if it works, market in 2 years. He said this to a tinnitus patient.
Log in or register to get the full forum benefits!
Similar threads
