Benadryl helped me with tinnitus, but also cause RLS (Restless Legs Syndrome)
The link below will take you to an article that gives a pretty in-depth, scientific explanation of how acetylcholine affects muscle contraction, and could provide you with some insights into how it caused your RLS --
@JohnAdams. Anticholinergic drugs essentially block acetylcholine receptors in the body, which is why they work as they do, and can negatively affect normal muscle contraction. Unfortunately, for some people, the side effects can be disastrous.
In my case, the anticholinergic drug I took tightened and constricted literally all my muscles, especially in the weaker areas of my body. A slightly problematic knee was pulled completely out of its normal alignment, and still has not recovered. Same thing happened in my lower back, neck and shoulder areas, mostly on my right side. I'm currently doing extensive physical therapy to try to correct some of these drug-induced misalignments; including TMJ realignment.
This abnormal muscle contraction may be the primary reason I developed significant tinnitus. There are acetylcholine receptors in all parts of the body, but--
of note to people with tinnitus and/or hyperacusis--I discovered they're also located in the inner ear. So if an anticholinergic drug is negatively affecting the muscles in the body in an unusual way, it's easy to imagine how it could cause some pretty serious inner ear and/or eustacian tube dysfunction, including Tonic tensor tympani syndrome (TTTS). I have symptoms of all of these things.
I have concerns there's an under-appreciation of how many of the drugs that are often discussed on this forum are anticholinergic, and how they have the potential to exacerbate the very ear problems we're trying to heal from. -- Check out
THIS POST for a fairly comprehensive list of anticholinergic drugs.
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The Effect of Acetylcholine on Muscle
Acetylcholine is a chemical messenger, a neurotransmitter, released by nerve cells in many parts of the peripheral nervous system. It controls the contraction of all skeletal or voluntary muscles, for instance.