WARNING: I AM NO SCIENTIST OR DOCTOR. PLEASE DO NOT CONSIDER THE FOLLOWING TO BE ALL TRUE. I AM IGNORANT IN MANY WAYS ON HOW THE BRAIN WORKS. I AM JUST PUTTING THIS OUT THERE AND HOPEFULLY WILL GET SOME FEEDBACK. IT COULD BE WAY OFF BASE. NEVER TAKE MEDICINE WITHOUT A DOCTOR'S PERMISSION.
As has been mentioned before, some people say that a "glutamate storm" (excitotoxicity) that can come from benzo withdrawal can cause tinnitus. According to Wikipedia:
Interestingly enough it says hearing loss through noise overexposure or otoxicity can cause excitotoxicity as well. According to Wikipedia:
So after doing a little research I found a video of a man explaining how glutamate works:
What I wonder and this could be completely ignorant is that if some of these nerve cells are damaged by a "glutamate storm" they might not uptake glutamate and leave the cell overexcited. Also, another idea of mine is that after glutamate reuptake, perhaps some of that glutamate could be converted to GABA during the glutamate decarboxylase process which then could later be used to inhibit neurons. (Not sure if that is the way it works because I am not a scientist, but just putting it out there)
After doing some research I found a drug called Riluzole that stimulates glutamate reuptake:
Interestingly enough it also says:
This is an off label use, as the main use is to treat ALS. Another disease that may be involved with excitotoxicity - please see third paragraph from the top. I do not know the long term consequences of someone taking this drug. I highly doubt this would get rid of tinnitus but wonder if it would lower it some or if it would help some people with depression and anxiety (or possibly obsessive thoughts?) about tinnitus.
I don't think I have read anywhere of people trying this drug out for tinnitus but I didn't really look that much. Also, this drug is very expensive (at least for me it is) but there is now a generic available. What do you guys think? Is this a stupid idea? Is this idea ignorant? Is it worth a try?
As has been mentioned before, some people say that a "glutamate storm" (excitotoxicity) that can come from benzo withdrawal can cause tinnitus. According to Wikipedia:
Excitotoxicity may be involved in spinal cord injury, stroke, traumatic brain injury, hearing loss (through noise overexposure or ototoxicity), and in neurodegenerative diseases of the central nervous system (CNS) such as multiple sclerosis, Alzheimer's disease, amyotrophic lateral sclerosis (ALS), Parkinson's disease, alcoholism or alcohol withdrawal and especially over-rapid benzodiazepine withdrawal, and also Huntington's disease.
Source:
https://en.wikipedia.org/wiki/Excitotoxicity
Source:
https://en.wikipedia.org/wiki/Excitotoxicity
Interestingly enough it says hearing loss through noise overexposure or otoxicity can cause excitotoxicity as well. According to Wikipedia:
Excitotoxicity is the pathological process by which nerve cells are damaged or killed by excessive stimulation by neurotransmitters such as glutamate and similar substances. This occurs when receptors for the excitatory neurotransmitter glutamate (glutamate receptors) such as the NMDA receptor and AMPA receptor are overactivated by glutamatergic storm.
So after doing a little research I found a video of a man explaining how glutamate works:
What I wonder and this could be completely ignorant is that if some of these nerve cells are damaged by a "glutamate storm" they might not uptake glutamate and leave the cell overexcited. Also, another idea of mine is that after glutamate reuptake, perhaps some of that glutamate could be converted to GABA during the glutamate decarboxylase process which then could later be used to inhibit neurons. (Not sure if that is the way it works because I am not a scientist, but just putting it out there)
After doing some research I found a drug called Riluzole that stimulates glutamate reuptake:
However, the action of riluzole on glutamate receptors has been controversial, as no binding of the drug to any known sites has been shown for them. In addition, as its antiglutamatergic action is still detectable in the presence of sodium channel blockers, it is also uncertain whether or not it acts via this way. Rather, its ability to stimulate glutamate uptake seems to mediate many of its effects.
Riluzole — Mechanism of Action:
https://en.wikipedia.org/wiki/Riluzole#Mechanism_of_Action
Riluzole — Mechanism of Action:
https://en.wikipedia.org/wiki/Riluzole#Mechanism_of_Action
Interestingly enough it also says:
A number of recent case studies have indicated that riluzole may have clinical use in mood and anxiety disorders. It has been shown to have antidepressant properties in the treatment of refractory depression and act as an anxiolytic in obsessive-compulsive disorder and in GAD.
This is an off label use, as the main use is to treat ALS. Another disease that may be involved with excitotoxicity - please see third paragraph from the top. I do not know the long term consequences of someone taking this drug. I highly doubt this would get rid of tinnitus but wonder if it would lower it some or if it would help some people with depression and anxiety (or possibly obsessive thoughts?) about tinnitus.
I don't think I have read anywhere of people trying this drug out for tinnitus but I didn't really look that much. Also, this drug is very expensive (at least for me it is) but there is now a generic available. What do you guys think? Is this a stupid idea? Is this idea ignorant? Is it worth a try?
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