So apparently it will take about two weeks before the test results come in. I will order new isolate after I've discussed the results with my doctor. Shipping internationally takes about six to eight weeks, so it'll be a while before I can continue with my experiment.
I am quitting cannabidiol cold turkey tomorrow, and keep a small reserve supply in case I get withdrawal symptoms.
Interesting. Look forward to some elaboration on this observance.
Has there been any change in your tinnitus that you've noticed, since your last post?
Considering the effects on my hyperacusis, I think it provides temporary relief for my pain hyperacusis after ingesting the oil. I wasn't sure about this before, but I think a single dose of 12.5mg/kg has made this effect more noticeable. For instance, a couple of times I noticed that my own voice sounds loud but less painful and harsh after taking it. I also noticed that I was less bothered about cars rushing by. As someone who has suffered from pain hyperacusis for 3 years, I don't think this was coincidental. I also do not believe it to be a placebo effect. But it is still too soon to tell for sure whether these results can be consistently replicated.
Considering long term hyperacusis improvements, it is difficult to tell. For the last few weeks my own voice has been pretty painful, more so than usual, but it could be due to the fact that I have been putting way more stress on my ears as well these last couple of months. The sound of rushing cars seem to feel a bit less painful strangely enough. It is interesting to think about the role of potassium channel openers in pain hyperacusis. Do they only prevent pain neurons from firing, or do they have a broader role in treating hyperacusis? Does it even make sense to ingest cannabidiol at fixed times in a day, or is it better to just take a dosage whenever you need?
For tinnitus, I haven't really noticed any positive effect. Since last week my tinnitus has been acting up. I don't know if that is related to the cannabidiol or not. It is important to note that poorer sleep is a known side effect of Epidiolex. I have noticed that my sleep quality has been of a declined quality these last couple of weeks, which could be the cause of my louder tinnitus. I am curious to see whether quitting cannabidiol will improve my sleep.
Even though the results of my experiment weren't exactly what I had hoped, I have reasons to believe that there is hope on the horizon for those with long term pain hyperacusis. I am curious to see what prolonged usage of a dose of 25mg/kg/day does for my tinnitus & hyperacusis. Will the temporary effect become more pronounced the longer I use it? Will my tinnitus start to improve as well? Would it be safe to take a single dose higher than 12.5mg/kg/?
35 grams for $450 (this time)?
That depends on the results of the blood test.
The problem with Extract Labs is that they only sell quantities of 5/25/100/500 g. If my liver values are OK, as in, nothing unusual is noticed, I will order 100 gram (with 25% discount).
If my liver values are compromised, I might have to stop the continues administration of the drug, but maybe it would still be possible to take it occasionally, so I might order 25g.
I will definitely give an update on the results of the blood test.
P.S.: In this study they used a maximum of 50mg/kg/day for patients with tuberous sclerosis complex. I don't know yet where this number comes from and if it is only applicable to TSC patients, but the effects of using even higher single doses than 12.5mg/kg seems like a promising subject of investigation.
Long-term cannabidiol treatment for seizures in patients with tuberous sclerosis complex: An open-label extension trial
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