Another tricyclic antidepressant, amitriptyline, was tested by Podoshin
et al. [
38]. One group was given 10mg of amitriptyline hydrochloride for 10 weeks, while a second group used a biofeedback device; each group had an associated placebo group. Amitriptyline decreased tinnitus in 27.5% of subjects at rest and in 15.8% of subjects during activity [
38]. However, a greater percentage of biofeedback users (43.5%) saw improvement during rest. Amitriptyline showed no significant advantage over placebo treatment. Side effects from amitriptyline (
e.g., sedation) were minimized by administering a low dosage. Nonetheless, seven patients discontinued treatment. Later, another study with 20 subjective tinnitus patients and 17 placebo subjects was conducted – neither group suffered from depression [
39]. Test subjects received 50mg of amitriptyline per day the first week and 100 mg per day the following five weeks. Only minor side effects of sedation and dryness of mouth were reported. Tinnitus severity was reported to decrease following treatment in 95% of the test group and only 12% in the placebo group.