Delix Therapeutics — Neuroplastogen for Hearing Loss

[Nick47]

Delix Therapeutics Awarded Grant from the U.S. Department of Defense to Advance Neuroplastogen for Hearing Loss

• Supports the development of a novel, non-hallucinogenic neuroplastogen to restore hearing by stimulating cochlear synaptic growth
  
  
• Reinforces the potential of Delix's proprietary neuroplasticity platform to identify neuroplastogens to treat a wide range of synapse-related disorders, beyond those associated with mental health conditions

 

[Muggumbo]

It seems that a lot of researchers are developing different kinds of goop to inject in our ears. Let's hope one of these works. I'd sign up for a tinnitus trial if they ever do one.

 

[rei]

Wow! This one is rather mind-blowing. I've just had conversations with two people about how microdosing Psilocybin for a month or two greatly helped their depression.

Paul Stamets claims that microdosing has more positive long-term effects than taking a larger dose.

I haven't touched the stuff in decades, but I'm now very intrigued.

 

[Alberte]

Does Delix Therapeutics' Neuroplastogen help tinnitus sufferers?

 

[tomytl]

This sounds really interesting.

Is there any more information available?

 

[Subjarna]

When can we expect progress in clinical trials for treatments of cochlear synaptopathy? Recent news suggests that scientists have found a way to repair synaptic connections, so what obstacles are still in the way?

 

[AverageJoe12]

When can we expect progress in clinical trials for treatments of cochlear synaptopathy? Recent news suggests that scientists have found a way to repair synaptic connections, so what obstacles are still in the way?

I believe synaptic repair has been limited to animals only so far, and it's possible that the therapeutic was only effective when administered within three days of acoustic trauma (per the interview below). I would take a closer look at it.

The discovery of cochlear synaptopathy dates back to '09, but science, medicine, and technology are slow to progress.

Though it's great to see an interview like this from 2023, pay close attention to Dr. Lieberman and his team at Mass Eye and Ear and Eaton-Peabody Laboratories. They may hold the key to the future of hearing health for those of us who suffer from 'hidden hearing loss' — tinnitus and hyperacusis but without any blatant hearing loss on an audiogram.

→ Interview with Charles Liberman, PhD 2022 La Fondation Pour l'Audition, Scientific Grand Prize Recipient