It may have been looked at in the 70s but the results appear to be positive AND I am fairly certain that they did not have the semiconductor technology in the 70s to produce the chips needed for small implantable devices to be used in this treatment. I personally believe this electrical stimulation of the cochlea is going to alleviate a lot of suffering and be the most impactful treatment of the next decade.
There was no placebo control group in this study, so this is worthless data. Plus, @Mentos, who took part in one of the trials was strongly encouraged to state that the treatment helped him, despite the fact that it did not. I have one more friend who used this method, and she was not happy either.
The lack of placebo control does not mean that the data is worthless. Dr. Djajilian and Mayo have both shown its effectiveness, which makes sense given the success that cochlear implants sometimes have.
Ooh, I am in California. Looks like Irvine is 6 hours and 17 minutes from me. I also believe I meet all of the qualifications, although I am on Amitriptyline for sleep as of right now.
If this was in the UK "I WOULD BE THERE LIKE A SHOT."
It is either non-invasive (ear canal) or minimally invasive (through the eardrum into the middle ear). I would absolutely love to be involved in a trial like this. Results from pilot studies have been very promising and Dr. Djalilian is a high profile ENT. It looks about as invasive as having a simple intratympanic injection, only this will use a small probe to electrically stimulate the cochlear and hopefully 'switch off' your tinnitus.
It could be they were not recruiting at the time. I noticed this was updated a few weeks ago to recruiting. It's great they are looking to recruit a decent sized cohort too.
Same. It looks like a well-balanced study technique and I'm all for this technology.
As I understand it, they will not be using implantable devices of any kind in the study? It's electrical stimulation using some sort of a probe, but on a larger scale to see the response rates in a larger cohort. We know smaller samples had good results. It seems they want to see if it works well in patients with cochlear implants too.
When I went back to the clinical trials website I saw:
Definitely. And as mentioned before, even if they're not considering CI for delivery during this phase, we know we already have a related CI safety/control group of sorts due to the studies done on CI patients' natural hearing >5 years post implant.
I wasn't aware of the visual disturbances, let's hope he can get that finely tuned.
I know this is something Kelly Assouly has been trying to do, getting big players involved in device manufacturing for tinnitus.MED-EL said:
I think you shared this a few weeks back.
I've looked at this again. It seems they want to find out what types/frequencies of electrical stimulation are needed to suppress a large cohort of tinnitus patients. For instance, square waves, narrow waves, sine waves etc.
Nicole said:
This is interesting. I remember seeing this a few years back when my tinnitus began and I totally forgot about it. It's like noise-cancelling for your brain! Hopefully the study results are positive.
I'm still really intrigued by this line of research for a number of reasons; the channels (potassium) and gating being the central ones though because of their equivalent in electronics. I need to do a proper post on it at some point - still trying to remember a load of stuff from way back when in college.
What were you expecting to hear? That sounds pretty good to me. They have all the people enrolled and they will complete the trial. If the results are good, they may not have to do another trial.
On ClinicalTrials.gov it states the the estimated study completion was December 2023, as in 2 months away. So I was just bummed to hear that the information wasn't up to date and that it won't be completed until a year from now.
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