It takes 2-4 weeks for gluten toxins to entirely flush out of your body. The gluten free diet also only works if you don't smoke and drink alcohol in terms of energy levels.I'm about 2 weeks into gluten free. I haven't noticed an impact on my hiss, I still get it at about the same frequency and intensity. I'm not detecting any change in my energy level, but I didn't consume a lot of gluten to begin with, as I've come to learn while learning which foods to avoid. I'm happy to continue doing gluten free though, perhaps I'll see an effect later.