Frequency Therapeutics — Hearing Loss Regeneration

[GregCA]

He does make it sound simple. I hope it materializes.

 

[JohnAdams]

Frequency Therapeutics. Tell us something PLEASE.

 

[Fabrikat]

Frequency Therapeutics. Tell us something PLEASE.

David Lucchino is such a big cochlear tease!

 

[Mr Mister]

Isn't this clip from 2017? He sounds like the cure is just around the corner and makes wonder what have they really achieved since? Did they ever publish formally the phase I results with details? I thought it was due early this year.

 

[Enclave]

I think it's important to point out that there are still no results posted from the Phase I they did in Australia well over a year ago, so everyone expecting something to be posted from the Phase 1.5 should adjust their expectations accordingly.

Both were "safety" studies.

 

[tarmaced]

I think it's important to point out that there are still no results posted from the Phase I they did in Australia well over a year ago, so everyone expecting something to be posted from the Phase 1.5 should adjust their expectations accordingly.

Both were "safety" studies.

An honest question: do they not have to post data following the trial to move past the phase 1 trial and into phase 2?

If not... why would any company do this, as some clearly do in the online portal?

 

[PDodge]

Isn't this clip from 2017? He sounds like the cure is just around the corner and makes wonder what have they really achieved since? Did they ever publish formally the phase I results with details? I thought it was due early this year.

Ya someone posted an article in the chat a few days ago that said the treatment would be 12-18 months away, I was like I f'n wish. There was no date on the article either.

 

[Mr Mister]

Ya someone posted an article in the chat a few days ago that said the treatment would be 12-18 months away, I was like I f'n wish. There was no date on the article either.

That clip can be found on YouTube and has a date August 23rd, 2017 so it's not new.

 

[Amv]

There is one new video on their webpage of a TV report about them. Things keep on going well. Cross your fingers guys, but it seems nothing is stopping them from continuing their work! Amazing company that has decided to go this way and they must have all of our support and best wishes! Hugs to all!

 

[PDodge]

That clip can be found on YouTube and has a date August 23rd, 2017 so it's not new.

I thought so. This drug is so insane, if it works as promised haha.

 

[JohnAdams]

I thought so. This drug is so insane, if it works as promised haha.

Nothing has been promised.

 

[PDodge]

Nothing has been promised.

Ok, as intended.

 

[Deathtotinni]

Assuming this drug has some type of efficacy, I can't believe no one who got it hasn't posted in this forum. I guess I'm also assuming they know about the forum.

I also can't believe there is zero news from the company.

Eventually I will learn the reality of my position and move on.

The news clip on the company now seems like clickbait.

Non-disclosure agreement and likely will get them kicked out of the next study.

 

[Street Novelist]

So, we're waiting for the summer? Is that the word? Is that when they publish the results or when they begin the next trial?

 

[ageoflove]

...our biggest hope to get FX-322 on the market soon is that the regeneration of OHC's and IHC's really works (in a functional way and on the right spots) and on the other hand that our brains' neuroplasticity takes place fast enough and in the right way.

I'm pretty sure the regeneration of hair cells in the human cochlea is not too far away.

What still seems to be very unknown is if the damaged synapses (hidden hearing loss) can grow (or rewire) in the right way...

...on top of that we have to see if our brains' (auditory cortex) are able to detect and interpret those new (or old...) signals in a (the) way which nature had determined.

In the best case:
- We hear better (child like)
- Tinnitus disappears
- No unwanted side effects (physical and neurological)

However maybe or at least I hope we can learn more about our little noisy friends. I wonder if it's really only the known noise, TMJ, TMD, head/neck, muscle, blood vessel stuff which causes tinnitus. Maybe we are already living in the "age of neurological diseases", with unknown viruses, inflammations, and stuff are responsible for the higher and higher number of tinnitus sufferers.

 

[Coleoptere]

So, we're waiting for the summer? Is that the word? Is that when they publish the results or when they begin the next trial?

They will start the next trial. It is dependent on the progress with the FDA impediment.

 

[TeslaGuy]

Hi to all fellow tinnitus sufferers! I am new here and I am glad that this condition is making awareness and there are companies trying to fix hearing loss and tinnitus for good. I got tinnitus when I was almost 13 in 2008. I was so young and I thought my days are over. Managed this for years but last year it really got to me.

Then I discovered this forum and Frequency Therapeutics. I truly believe that we all have hope and we get to hear some results soon enough

 

[Piney]

They said news was to be out in December I believe. Well let's hope it's delayed for a good reason.

 

[JohnAdams]

I'm pretty sure the regeneration of hair cells in the human cochlea is not too far away.

I think I have already experienced this to some degree.

 

[JohnAdams]

Who else here checks the Frequency Therapeutics website and the FDA site daily?

 

[tarmaced]

Who else here checks the Frequency Therapeutics website and the FDA site daily?

I'll be honest, I just check this thread, I know you have got this one!

 

[Aleksa Uzunovic]

Hey folks,

I've been following this forum for a while now, and I'm always checking whether some of these companies are close to putting a product on the market to end our inconvenience with hearing loss/tinnitus.

I, myself have a noise induced hearing loss from loud music at 22 and would take 20 injections in a heartbeat to get my hearing to better level. Tinnitus on my left ear is quite strong but most of the time I've trained myself not to pay attention to it.

JohnAdams seems to be some of the most knowledgeable folks here and it's good reading your conclusions of potential treatments and positive words, you are one of those people that keep the world moving bud! Additionally, these companies in the United States really seem to be slow with moving things forward, even though they would be making ludicrous amounts of Benjamins if they placed their product on the market.

Anyway JohnAdams I've read your comments on IGF-1 and that that might regenerate cells safely, looking forward to see that thing working out, and if it does I would be more than willing to take a few shots in the ear to cure myself and not wait for these companies and FDA to move their asses.

Greetings from Dubai

 

[JohnAdams]

Additionally, these companies in the United States really seem to be slow with moving things forward, even though they would be making ludicrous amounts of Benjamins if they placed their product on the market.

They would go as fast as possible if they could. It's the FDA. While very important in theory, they work incredibly slowly and even waste lots of time. I think that the system is broken because they approve things that hurt and kill people and also slow down things that could save lives, which is exactly the opposite of what they exist for.

 

[Carlos1]

@JohnAdams
I've reached out to Frequency Therqpeutics and asked to participate in any clinical trials they may have in the future.

There reply was for me to refer to:
www.clinicaltrials.gov

I live in the area so I'd love to participate... we'll see what happens.

Carlos

 

[GSC]

Personally, I watch this thread more than the MuteButton one. This is our holy grail.

 

[JohnAdams]

Personally, I watch this thread more than the MuteButton one. This is our holy grail.

Maybe so. What we really need is the government to sue 3M and use the money to create a special division at the FDA to focus specifically on this drug. That would probably take as long as getting it approved as is.

 

[ageoflove]

I gotta say I'm, at least a bit, a fan of Liberman's Hidden Hearing Loss Theory which is pointing out that loss of synapses causes hearing loss which could only be measured under distinct conditions (worse speech, especially speech in noise understanding ability...). Liberman also points out that it may be synaptic "trouble", which influences the hearing nerve and all of the following brain periphery afterwards, and ultimately may be the cause of tinnitus (or the noise induced types).

Most elderly people suffer from this (speech in noise trouble), with ENT doctors explaining this by high frequency hearing loss in their standard audiograms.

Synaptic damage is not really measurable right now, because if you measure ABR waves and stuff like that, you already are going to measure the hyperactive tinnitus signal. This hyperactivity seems to be generated by our bodies (brains) to keep the rarely/or unused nerve structures busy/alive.

Liberman's Theory would also explain why more than half (excuse me if I cannot give you exact numbers) of the people with significant hearing deficits/damage don't experience "loud" tinnitus.

I also read some studies that the mixture of hair cell & synaptic damage could be compared to the compression of audio files (like compare 320 kbps mp3 to 128 kbps mp3 files. Hearing aids just boost the gain (at least in certain frequencies) but if you listen to a bad source, gain only will not not make the sound quality (speech in noise recognition) better. Think of people looking at "funny" smartphone recorded viral videos which often have so bad audio quality that they have to crank up the volume to the max so you can barely understand the voices but the distortion nearly blows up your eardrums (sarcasm!)

To me another reason is that a lot of elder people with hearing aids claim those don't help them, and audiologists claiming that their brain structures "have reduced" because they got no input for a long time...

Fix hair cells and synapses and hope that neuroplastic (input) changes in brains (reorganisation of the auditory cortex) are not permanent and we get rid of this shit. I'm pretty sure!

 

[d'Wooluf]

They said news was to be out in December I believe. Well let's hope it's delayed for a good reason.

The status of the study is Active - Not recruiting, which means...

"The study is ongoing, and participants are receiving an intervention or being examined, but potential participants are not currently being recruited or enrolled."

So, the reason there's no news is that the study hasn't finished. The reason it hasn't finished is... ?

 

[TeslaGuy]

Liberman's Theory would also explain why more
To me another reason is that a lot of elder people with hearing aids claim those don't help them, and audiologists claiming that their brain structures "have reduced" because they got no input for a long time...

Fix hair cells and synapses and hope that neuroplastic (input) changes in brains (reorganisation of the auditory cortex) are not permanent and we get rid of this shit. I'm pretty sure!

I truly hope that the neuroplastic changes are not permanent and why should it be? If the brain has the ability to adapt to hearing loss why it could not adapt to regaining hearing. I think it is little bit different scenario when hair cells and synapses are restored and functional than using the remaining ones with amplification. Only time will tell how it is.

 

[tomytl]

The status of the study is Active - Not recruiting, which means...

"The study is ongoing, and participants are receiving an intervention or being examined, but potential participants are not currently being recruited or enrolled."

So, the reason there's no news is that the study hasn't finished. The reason it hasn't finished is... ?

Probably they had no effect or very different effects? Would it be much faster if all participants got perfect hearing?

It's very exciting to know.

But in a phase 1 trial, wouldn't they see if there was some positive effect?