Frequency Therapeutics — Hearing Loss Regeneration

#3,601
Have any of the researchers for Frequency Therapeutics or REGAIN ever stated that hearing regeneration would solve tinnitus or hypercausis?

Anyway, good news that everything seems to be going to plan. This could be the 1/10 drug that actually goes to the market.

Perhaps in 5 years' time, hearing restoration could take off a bit like laser eye surgery.

Anyway this is going to be if it's not already a worldwide crisis with a noisy world, just get hearing regeneration and I'm like a zebra fish, happy days.
 
#3,602
See, I told you guys that they would know about efficacy and this was more than a safety study.
It would be completely ridiculous for them to not have tested efficacy.
:p

Now we know it works in humans and I've been saying it would all along as did @Deathtotinni. Now the question is how well did it work and how many doses per amount of hearing loss will it take to iron out our good friend tinnitus.
 
#3,603
JohnAdams said:
All of this shows that mankind is on the edge of a massive breakthrough in regenerating all kinds of damage to the human body, not just in our ears. I believe strongly that this type of technology will advance exponentially.
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The ears seem to be among the most complicated though? You can't even get a good picture (internally). Plus, the interaction within the brain. I hope all the optimism is justified and each one (or at least one) of the researchers make a contribution towards restoring hearing loss and eliminating both tinnitus and hyperacusis.
 
#3,604
It was stated in 2012 hair cells can reach out and regrow synapses and nerve fibers. Don't rain on my parade, not today. Give me something to hold steady.
 
#3,605
Contrast said:
I hate to burst the bubble but it seems widescale synaptopathic (synapse and nerve related) hearing loss, and noise induced pain hyperacusis still have to wait for Otonomy and Decibel Therapeutics if they can address it.
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I disagree as I recall Frequency Therapeutics stating that hair cell growth can trigger new synaptic connections.
 
#3,606
upload_2019-4-9_13-19-24.png
 
#3,607
What is the criteria to move on to the next stage? Is there a certain percentage effectiveness rate? What degree of hearing restoration would be required? Just that on an audiogram or can hidden hearing loss be restored/included?
 
#3,609
Flamingo1 said:
I disagree as I recall Frequency Therapeutics stating that hair cell growth can trigger new synaptic connections.
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If this is the case obviously, which I'm not disagreeing with of course, but if it is, does anyone know why Otonomy is working on one that specifically targets hidden hearing loss then? Is that for the moderate to severe there - where cell growth can't trigger anything, because they're just dead? Or...
 
#3,610
TeslaGuy said:
That is true. They said also that in song birds they not only regrow hair cells but they also connect all the way to the brain. That proves it.
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A few years ago (the last time I scanned around for the state of tinnitus research before joining this forum) I read articles talking about how the difference between bird and mammal genes comes down to one little snippet. The idea was to use gene therapy to turn back ON hair-cell regeneration and then this would just happen on its own. This is different from the Frequency Therapeutics approach which is some sort of chemical stimulant to force regeneration.
 
#3,611
GlennS said:
A few years ago (the last time I scanned around for the state of tinnitus research before joining this forum) I read articles talking about how the difference between bird and mammal genes comes down to one little snippet. The idea was to use gene therapy to turn back ON hair-cell regeneration and then this would just happen on its own. This is different from the Frequency Therapeutics approach which is some sort of chemical stimulant to force regeneration.
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That would be the ultimate one. Gene therapy to hit that switch and awaken it within humans, so people would be able to regrow their hair cells as well. Though that leads to an amass of other things - possibly dangerous territories - if it's not measured and such.
 
#3,613
GSC said:
That would be the ultimate one. Gene therapy to hit that switch and awaken it within humans, so people would be able to regrow their hair cells as well. Though that leads to an amass of other things - possibly dangerous territories - if it's not measured and such.
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I read the article what he's talking about. Humans already have the switch. It just doesn't turn on for some reason. For the other animals, it turns on to heal the damage.
 
#3,614
I have anosmia. Guess what it's from, SSHL and passing out and hitting the back of my head. Call it localization issues 3 months in. So yeah, I'm all over Frequency Therapeutics like white in rice.
 
#3,615
Piney said:
I have anosmia. Guess what it's from, SSHL and passing out and hitting the back of my head. Call it localization issues 3 months in. So yeah, I'm all over Frequency Therapeutics like white in rice.
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Is it head trauma or cochlear damage?
 
#3,616
Any thoughts how much this treatment would cost if it becomes available? After all it seems to be very simple procedure of injecting small molecules but it would still cost a lot. Wonder if this ever becomes available in local health centers rather than special clinics.
 
#3,617
This is great but I don't understand why their next step is multiple doses unless the improvements seen were only minimal. I guess we'll have to wait and see about this, maybe the improvements were actually decent but they are aiming for a lot more.
 
#3,618
Mr Mister said:
While this is very positive news I get a feeling that Frequency Therapeutics is falling behind in schedule compared to REGAIN. They stated this a couple of months ago: "We can share that we have successfully completed the Phase I safety study and will start the Phase II efficacy study within the next few weeks. The results of the phase I and II REGAIN studies will be published after the completion and data analysis of both studies; we are aiming for early 2020."
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That could still be in Frequency Therapeutics's favor. From what I understand, they are being REALLY CAREFUL not only with their trials but also their information, their press coverage, interpreting data, etc... Regain might be going faster but sometimes faster isn't better. Sometimes faster means that you make mistakes or you don't fully think things through.
 
#3,622
Mr Mister said:
Just let us know how much improvement :)
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They may in time. For me, any measurable improvement in even just one subject is huge. It demonstrates that treatment for sudden sensorineural hearing loss is a tangible possibility. And it demonstrates it not in a dish or in a mouse but in an actual person. I think people might start believing it now and things will move forward from here.
 
#3,623
#3,625
derpytia said:
Regain might be going faster but sometimes faster isn't better.
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My understanding is that Regain set the timeline right from the start. The phase 1 study was always going to take a year. The phase 2 study (it it happened) was always going to take a year. That doesn't sound that fast to me.
 
#3,627
d'Wooluf said:
That's one question. Another is how many people are qualified to do it and how much time can they spare over and above their current workloads.
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That and the state of healthcare systems across the globe. I am no expert on healthcare in other countries besides my own but I can tell you that healthcare in the USA is walking a tightrope right now due to political divisions and such. If Frequency Therapeutics's treatment makes the market, it will be years from now and who knows what the state of US healthcare will be then.
 
#3,630
Aleksa Uzunovic said:
Why wait later this year??? WHY NOT START PHASE 2 IMMEDIATELY?! Just don't be a bunch of procrastinating dimwits will ya!
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Trust me, they would like to figure out the dosage and get to market as soon as possible. This is going to be a huge money maker and they want money. They have to work within the framework of the FDA and that is going to be the primary bottleneck getting to market. Something like the FDA is totally necessary but for this I'd think they should grant special attention to it considering all the vets and the other drugs that they've approved that actually caused tinnitus. Overall the FDA has our best interests in mind. We can't just have companies selling products that specifically claim to treat tinnitus that don't work.

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