Frequency Therapeutics — Hearing Loss Regeneration

#3,781
FGG said:
Would this drug navigate the round window properly and, if so, would you suppose hydrops would interfere with effectiveness?
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Well, these are questions I don't know the absolute answer to, but my immediate thought is that yes, cochlear hydrops would in fact interfere with this drug's effectiveness.
 
#3,782
JohnAdams said:
Well, these are questions I don't know the absolute answer to, but my immediate thought is that yes, cochlear hydrops would in fact interfere with this drug's effectiveness.
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I wonder if it would it depend on if you were having an episode though as Meniere's tends to be episodic doesn't it? So if you were able to get the treatment at a time when fluid retention was at a minimum I suppose the drug could do its thing still.
 
#3,784
To be optimistic it's nice to see that both projects seems to have the same results.

Frequency Therapeutics wants to present their results at a big conference if I understood their latest update correctly. Does anyone here know which conference that is?
 
#3,785
Remjii79 said:
I wonder if it would it depend on if you were having an episode though as Meniere's tends to be episodic doesn't it? So if you were able to get the treatment at a time when fluid retention was at a minimum I suppose the drug could do its thing still.
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This is my hope.
 
#3,787
"Frequency plans to present the Phase 1/2 results at a major otolaryngology meeting in 2019 and to submit the results for publication. The company believes the results of this study support the advancement of FX-322 into a multiple dose Phase 2a study, which it plans to initiate later this year."


From their press release... Does anyone know when that "major otolaryngology meeting" is supposed to be held? I bet we will have to wait for August/early September for the next trial to start.
 
#3,795
Jazzer said:
John - does this imply that you have no faith in bimodal stimulation then John?
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No. I just think it's incredibly inferior. But I guess time will tell. Those testimonials Neuromod put out looked like a heap of crap though to be honest.

I liken it to fixing a problem vs fixing a symptom of a problem.
 
#3,797
reeseth said:
Mine as well! My Plan-B is CI, but wanna save that last card as long as possible.
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A wise choice.

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#3,798
jeff W said:
A wise choice.

View attachment 29363
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Yes, I agree a CI should be a last resort. I'm holding out as well to see what happens with FX-322. From what I understand there is no going back from a CI procedure. The results also seem mixed from what I have read. I'll hold out until I go completely deaf before going that route.

Clint: It is still a possibility that we restore hearing and tinnitus still remains. There are theories that once it is embedded in the brain it won't go away. I am a firm believer that if you restore hearing then tinnitus will go away if your tinnitus is due to hearing loss. I also believe that you have to get your hearing pretty close to baseline before the tinnitus will completely go away and that is still not certain with FX-322. If the multiple dose approach works then we have a chance.
 
#3,799
JohnAdams said:
It can only help hearing loss via ear drum injections because the cochlea has a permeable membrane called the round window. Will McLean stated somewhere that the drug actually does a better job regrowing vestibular haircells in vitro but how would you administer it to the vestibule?
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#3,800
WickedCarnival said:
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Yeah I've seen this. There's no need. A needle is fast and easy. Hurts a little but who cares? You can't be a wimp and have tinnitus. Besides, you'd have to mix, therefore diluting, any drug, with ferrous (metals that interact with a magnetic field) nano particle and hope that it isn't ototoxic. Do you want ferrous nano particles floating around in your cochlea? I'll answer that for you. "Hell no".

I really don't see this being feasible in any way. It's a dream.

The best way is to use IT injections and then just lay there with your head tilted for an hour or so while the substance diffuses into the round window.

Also concerning Otomagnetics, think about it. The middle ear is a hollow cavity. You won't be able to use this technology to introduce a large enough amount of substance quickly enough to fill up the middle ear to the point were it is resting on the round window, it will only diffuse through the eardrum very very slowly. It would take hours and hours to permeate the eardrum with the same amount of substance that you could just inject in 5 seconds. Also, how can the magnet be on the same side as your head as the ear your treating? Magnets attract. You would have to position the magnet on the opposite side of the head as the ear that you are treating. A forward facing magnet cannot suspend ferrous material at a set distance, that's called levitation and can only be achieved with materials that are supercooled cryogenically.

Like I said, this is a dream. There's nothing wrong with an IT injection with a needle, so long as the physician is competent.
 
#3,801
Hello all. My name is Adam, age 19, from Florida. I found out I have tinnitus roughly a year ago, from the silliest things. I believe I got it from playing music too loud in my car and listening to music with the volume too high in my headphones. Stupid I know, but what can I say, I love music and I like to get amped when I listen to it. Take that as a note for those of you who may be reading this but don't have tinnitus. If you listen to music too loud now, stop before it's too late. There have been days where I haven't wanted to wake up because of my ringing. No medication or LipoFlavonoid helps. And to make things worse, I'm a weed smoker, and whenever I smoke the ringing is amplified. Somehow I've gotten used to that. Somehow I've gotten used to all of this. There have been days I've woken up and immediately heard the ringing and have had thoughts of killing myself. Ending it all. But I won't do that. I'm still here. And that's because it's against my religion to kill myself, but more importantly, because this page gave me hope.


I saw a couple of months ago that halfway through this year we would receive news regarding Frequency Therepeautics trials and whether or not their product would work on humans. I read that we would know by May most likely, so I am here to ask if there are any updates.

Has the stem cell regenerating drug that you inject in your ear been created? And was it a success? If not, are there other drugs being developed and if so please explain them to me.

I'm going to read through what has been recently added but if it's possible could someone please break down for me the results of the trial if we have them and let me know if the drug was a success? Please let me know ASAP! Thank you.

Tinnitus strong! Stay determined everyone! We will all get through this.
 
#3,802
I am really optimistic in the clinical trials by Frequency Therapeutics and the REGAIN-project. Both published early positive results/press releases after the phase 1/2 trial. I want to restore my hearing! And I hope that the tinnitus will reduce once the hearing is restored. I hope that the drug candidates they have now used will work!

Does anyone have anything new in regards to updates?

Best regards from Germany!
 
#3,803
In a nutshell: The most recent (phase 1b) trial completed with no serious negative effects of FX-322 on the participants. That was its main endpoint. However, they also stated that 'multiple' participants had shown improvement in their audiograms and word recognition scores. They gave no numbers or elaboration, but said they will present their findings at a major conference. They also said that they are on track for a phase 2a study later in the year. They were no more specific than that.

Prior to that they received another round of funding, leading us to surmise that they had managed to convince investors that their program was on track. Put those together and it seems very positive.

All we know from the REGAIN project is that phase 1 achieved its safety endpoints and that phase 2 is now underway. No indication on whether any participants in phase 1 showed any measurable improvements in hearing.
 
#3,804
OK. Thank you for the nutshell! So do you think that Frequency Therapeutics is a step forward to hearing loss restoration? It sounds like that... Or is it just our hope that makes us so optimistic?
 
#3,805
JohnAdams said:
Yeah I've seen this. There's no need. A needle is fast and easy. Hurts a little but who cares? You can't be a wimp and have tinnitus. Besides, you'd have to mix, therefore diluting, any drug, with ferrous (metals that interact with a magnetic field) nano particle and hope that it isn't ototoxic. Do you want ferrous nano particles floating around in your cochlea? I'll answer that for you. "Hell no".

I really don't see this being feasible in any way. It's a dream.

The best way is to use IT injections and then just lay there with your head tilted for an hour or so while the substance diffuses into the round window.

Also concerning Otomagnetics, think about it. The middle ear is a hollow cavity. You won't be able to use this technology to introduce a large enough amount of substance quickly enough to fill up the middle ear to the point were it is resting on the round window, it will only diffuse through the eardrum very very slowly. It would take hours and hours to permeate the eardrum with the same amount of substance that you could just inject in 5 seconds. Also, how can the magnet be on the same side as your head as the ear your treating? Magnets attract. You would have to position the magnet on the opposite side of the head as the ear that you are treating. A forward facing magnet cannot suspend ferrous material at a set distance, that's called levitation and can only be achieved with materials that are supercooled cryogenically.

Like I said, this is a dream. There's nothing wrong with an IT injection with a needle, so long as the physician is competent.
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Sounds like toxic negativity on your part. I have bad tinnitus as well, but that has no effect on the good scientific work Otomagnetics is doing. They've already received research grants and present at conferences, so it will be a reality in the future.
 
#3,806
#3,807
I agree with John. The intratympanic injection has been in use for years and it works fine. Why should they use something with magnetism when the diffusion through the round window is a tested and effective method? And... I don't want to have something "magnetic" in my ear...
 
#3,808
@Shelly75

Hearing aids do not cover the range of hidden hearing loss. Those children could be suffering from hidden hearing loss, or their tinnitus can come from a 5 db dip that is still in the normal range of hearing. Maybe the hair cells aren't damaged enough so they can be salvaged with resting your ears, or nerve repair. Maybe your brain gets use to your new range of hearing, which is why some people's tinnitus fades or goes into remission. Those people who woke up with tinnitus probably broke the camel's back - and will not know, because hidden hearing loss is not tested for.

Or even smaller cases - TMJ/TMD/ETD/NECK ISSUES etc<-- all other lesser causes that induce tinnitus.
 
#3,809
JoNo78 said:
OK. Thank you for the nutshell! So do you think that Frequency Therapeutics is a step forward to hearing loss restoration? It sounds like that... Or is it just our hope that makes us so optimistic?
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Their treatment improved functional hearing for at two people with sudden sensorineural hearing loss. I don't think that's ever been done before. Sounds like a step forward to me.
 
#3,810
JoNo78 said:
The intratympanic injection has been in use for years and it works fine.
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I've brought this up before and didn't get any responses. What happens if all our dreams come true and FX-322 is proved to be a successful treatment for hearing loss? How many people are going to be seeking treatment? Well, millions if it's really that good. How many people are qualified to administer intratympanic injections right now? How much time can they spare from their current duties? What kind of waiting lists would you expect?

I'm thinking a backup method of treatment that you could train nurses or techs to do might be nice to have.
 

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