Just to add some clarification, the FX-322 phase 1 was showing early positive results in live humans. Agreed that we want to see more that with this ongoing Phase 2 trial.
Frequency Therapeutics — Hearing Loss Regeneration
- Thread starter RB2014
- Start date
Member
After a few of us hounded them for nearly 2 weeks, Degiro have finally added Frequency Therapeutics to their trading platform, ASIN US35803L1089. If anyone (in Europe) is looking for a cheap way to purchase them.
That's true, I stand corrected. But it's also a fact that it's a lot easier to get enough of a drug in a donated cochlea than in real life patients. We don't know if human supporting cells are too refractory to respond to FX-322 in the concentration you can get into the inner ear intratympanically.
That is indeed the question. Hopefully multiple doses can do the job. If all fails, I read somewhere on this forum that they are developing a needle that can worm its way into the round window, which seems like a neat trick if they can pull it off.
Do you mean the microneedle that's being developed at Columbia University? BTW, does anybody know when they're going to test it in a clinical trial? Is there a schedule?
https://news.columbia.edu/news/surgeon-tries-reach-behind-eardrum-treat-hearing-disorders
Don't know when they will do a trial. I think they're finishing their research first soon. Then I suppose a company has to put resources in it.
That's such a long way to go... We'd better cross our fingers and hope the FX-322 treatment works as it is
Coleoptere
Member
Does it need all the 1-2-3 phases? And again 1-2-3 once used together with FX-322?
Don't think so. Let's say in 10 years time there are 5 injectable drugs that are used to treat hearing loss or tinnitus. That would mean every new delivery method would have to go through trials for each of those individual drugs.
Needles and other delivery methods have their own approval process for 'medical devices'. Once it's approved, it can be used with any drug so as long that drug's also approved.
Remember: Frequency is using a hydrogel right now. Hydrogels have never been approved specifically for FX-322. They were probably just approved a long time ago as a medical device to deliver drugs into the inner ear. And now FX-322 benefits.
Keep your chin up. Your audiogram is fine up until 8000 Hz so it's no wonder. Should they find out after Phase 2a the drug restores ultra-high frequencies you can still benefit in a Phase 2b. Should they decide they don't want to market it for that purpose despite its efficacy (because of small patient population), you could still get it off-label from your ENT once it's released.I don't qualify. Gutted
By the way, I wouldn't be surprised if this drug became very popular off-label. Right now it's not being tested for age-related hearing loss (presbycusis), just for noise-related hearing loss and sudden idiopathic hearing loss. If this gets approved, a lot of ENTs will want to offer this to old people, particularly if they are at a higher risk for dementia.
One of the nurses also commented that they were surprised I couldn't listen to music at all or watch TV without captions with my audiogram. There is clearly more to my sudden hearing loss than just hair cell loss (though I definitely have that at higher frequencies, too). I think maybe I should try for a synatopathy drug trial, if I can get in one.
Hi everyone. Rick from Norway here.
I've got classic NIHL, attached is my audiogram. I am thinking that it is better to wait until they have done extensive research in order to get the most out of the treatment from Frequency Therapeutics. I should be a perfect test candidate though, since my audiogram has been steady for at least 14 months.
I've got classic NIHL, attached is my audiogram. I am thinking that it is better to wait until they have done extensive research in order to get the most out of the treatment from Frequency Therapeutics. I should be a perfect test candidate though, since my audiogram has been steady for at least 14 months.
Attachments
I feel sad, crushed. All music sounds muffled and distorted to me regardless of the frequency. Some parts of every song sound far away and other parts are just missing. It definitely had a quality like a blown out speaker. Oddly, I can pick out most lyrics just fine but when watching TV if it has any background noise (i.e. anything but news), I need captions to understand about 30% of what is spoken.
This all happened suddenly Feb 1st, though I had tinnitus that started a month earlier.
So if any of you were to get approved for the phase 2 trial, would you not do it for some reason? For example, it potentially making things worse or the possibility of long term damage?
I guess I'm just curious if there are any risks with this procedure or drug they stick in your ear.
I guess I'm just curious if there are any risks with this procedure or drug they stick in your ear.
So strange... it's things like these that makes me angry that science hasn't got these diseases figured out yet. I originally wanted to be a neuroscientist, but I knew I didn't have the money to go for it so I did marketing instead...
If I get better (my tinnitus is pretty damn severe now and I am nowhere near close to habituating the way my sleep is going), I'm going to keep pursuing my dream of neuroscience. There's so much work that needs to be done, so many life-changing diseases people have to just live with. Chronic diseases without any treatment need to be a thing of the past.
FGG I'd like to offer you hope. I've read a success story on here where the person had similar "broken speaker" sounds and it went away after around 2 years.
Please look up my thread noise induced success stories that give you hope. The 4th one down I posted I think is the one where a broken speaker sound is mentioned.
I'd hug you now if I could. I'm in a similar situation, but I have pretty bad hearing loss (worse than you, in any case), and when there's (loud) background noise I can't hear much. I think what we need is both hair cell regeneration and synapse repair for the surviving hair cells (I see Otonomy has started its trial for OTO-413, link here https://clinicaltrials.gov/ct2/show/NCT04129775?term=otonomy&draw=3, maybe you can get in if it's in your state).
And I thought, maybe it's also the number of hair cells in each cochlear region that matters. Maybe you can have enough hair cells to detect the sound, so you respond well to pure-tones, but not enough to create a signal that makes sense to the brain...
Hey, I see you went to South Korea to that doctor, Minbo Shim.
If he offers that PRP + stem cells treatment anyway, can't he offer sustained-exposure BDNF treatments as well (the drug Otonomy is currently testing)?
Aleksa Uzunovic
Member
- Apr 2, 2019
- 43
- Tinnitus Since
- 2014
- Cause of Tinnitus
- Noise induced hearing loss
Ey guys, it's great that FX-322 got fast track status. Shouldn't we be optimistic now about it because it restored hearing in mice? That makes it a 99% chance that it will work in humans, right?
- Feb 6, 2018
- 1,169
- Tinnitus Since
- 11/2002; spike 2009; worse 2017-18
- Cause of Tinnitus
- Loud music - noise damage
LOL no.
Cancer, Alzheimer's, Parkinson's, MS, dental caries, everything has been cured in mice already.
Translating that to humans IS NOT straightforward. Most successful mice studies fail in humans.
It's just in mice! This scientist is calling out hype in science reporting
Twitter account: https://twitter.com/justsaysinmice
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