Hearing in, tinnitus out. That´s the hypothesis.
Most people here have noise induced tinnitus.
Frequency Therapeutics — Hearing Loss Regeneration
- Thread starter RB2014
- Start date
Most people here have noise induced tinnitus.
Member
There are a lot of people who have tinnitus from hearing loss. In addition, phase 2b is looking at FX-322 for tinnitus on their experimental arm. They even mention tinnitus specifically at the end of their recent presentation.
There are many researchers who think most tinnitus is due to either hearing loss or hidden hearing loss.
If this particular thread doesn't interest you, you can always browse others.
- Jun 15, 2019
- 157
- Tinnitus Since
- May 2019
- Cause of Tinnitus
- Likely infection/ear stress after walking pneumonia
I've only been here since May, but I doubt you'll find much sympathy for restricting discussion that way. There is a very strong correlation between the onset of hearing loss followed by tinnitus--in fact, I didn't really notice I had hearing loss until tinnitus led me to an ENT who immediately set me up for a hearing test once I told him about the tinnitus (which until that week I didn't even know what to call it).
Many people losing hearing don't get tinnitus, and vice-versa, but the relationship is strong enough to attract discussion by folks like us and medical research since the association is firmly established. And as stated in the case of FX-322, they're looking into it as well.
HootOwl
Member
They are currently enrolling for 2a and tinnitus is an exclusion factor, so it would have to be for 2b.
Maybe it's silly, but the fact that they are calling it Phase 2a, implies there will probably be a Phase 2b. They're trying to establish dose dependency right now. That's probably also the reason they want to double it from 1 injection FX-322 (3 placebo), to 2 injections FX-322 (2 placebo) and ultimately 4 injections FX-322. They also want to follow patients for six months because in Phase 1/2 after the 3 month follow up some patients were still improving.
My guess they will take this data to a Phase 2b trial (like the maximum tested dose dependency) and maybe expand to new patient populations, like the elderly (presbyacusis - also mentioned in their IPO).
RingingBrother
Member
- Oct 27, 2019
- 96
- Tinnitus Since
- 2018
- Cause of Tinnitus
- Noise induced hearing loss
They used the term phase 1a but went to phase 2 next. I hope the FDA is cutting them some slack to get this out sooner.
RingingBrother
Member
- Oct 27, 2019
- 96
- Tinnitus Since
- 2018
- Cause of Tinnitus
- Noise induced hearing loss
I saw Karuna Therapeutics went up over 600% on the stock market after they passed phase 2 for a schizophrenia treatment. Does anyone think the same can happen with FREQ stock if they pass phase 2?
Not that I know. They had a Phase 1 study on patients inbound for a cochlear implant and then a Phase 1/2 study.
It usually takes a couple months for the FDA to approve the drug, I wouldn't be surprised if it takes >6 months.
By normal you mean 0-8000 Hz right? I think this drug will only have effect if there's some measurable sensorineural hearing loss. If a patient's audiogram is also normal from 0-16000 Hz, what hair cell damage is this drug supposed to fix? In those cases the cause of tinnitus is probably something other than hair cell damage.
HootOwl
Member
I picked up a few of shares because I believe in the company, however, there's a lot of risk involved when investing in these types of companies. You just have to look at the stock prices for Auris Medical (EARS) and Otonomy (OTIC) to see what happens when drugs don't pan out as expected. I wouldn't invest any money that you wouldn't mind losing. It's easy to make illogical decisions when you want the results to be positive.
I read an article that came out that said it was under valued at the current stock price. Even though it is risky I do see some upside potential as long as the market doesn't crash. It has been steadily going up as well as more people find out about it and invest. I think you'll make some money in the coming months... and I think you could probably sell at a profit and get out at that time.
Now the million dollar question is whether to ride it out till the end... I think that is a gamble, but it could pay off. I'd take the easy money that says get out while the getting is good.
I think it was mentioned that a fair valuation was at around 27.50 dollars per share and if these articles keep coming out supporting that, I think it will actually hit it.
https://finance.yahoo.com/news/3-strong-buy-biotech-stocks-164019585.html
Fabrikat
Member
- May 1, 2017
- 416
- Tinnitus Since
- 1973
- Cause of Tinnitus
- Otosclerosis then volume then viral infection
I know nothing about share trading in bio stocks, but I would suggest that Frequency Therapeutics isn't just about ears, it's about a specific type of technology called progenitor cell activation. It's a bio engineering tool that can be applied to a variety of the body's organs and nerves.
It may fall down when it comes to the ears. We don't know yet. But it may well be successful with say intestinal issues or perhaps with MS. It's got potential in other areas yet to unfold.
So Frequency Therapeutics is a long term prospect with much potential that goes well beyond success or failure in the hearing program. I imagine this is why it's attracted such sizeable financial input from investment houses that are prudent risk takers. If it's a gamble, it looks like a reasonably good one.
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