My tinnitus fluctuates quite a bit. When my tinnitus is active I notice an increase in hyperacusis. My tinnitus has slowly improved since it started 20 months ago. As my tinnitus has improved the fullness in my more damaged ear has dissipated with a decrease in hyperacusis. If FX-322 can cure or lessen tinnitus it should take care of hyperacusis, at least in my case.
This is what I'm hoping as well. If you look at the Pipeline presentation the amount of synaptic regeneration was highly dependent on dose. Frequency could very well find that the 4 dose cohort show exceptional gains.
That's an interesting question that I've thought about myself. Some deafness at birth is the result of genetics, though I haven't looked into the specific mechanisms. I would guess that if a person simply doesn't have progenitor cells in their cochlea then FX-322 won't do anything for them. If the deafness has some other cause not related to genetics then maybe it could work.
It would work for sensorineural hearing loss, but there are other companies which are developing treatments for genetic hearing loss, if that's the cause.
I'm hoping it will be based on the current theory driving the underlying pathology of both pain and loudness hyperacusis.
I do not think this will work for cases of genetic deafness because that usually isn't due to just an absence of hair cell with progenitors in place.
Hm, well not really. The good news is that OTO-313 has nothing to do with hearing regeneration of any kind. It is an analog of an NMDA antagonist they had been trialed in the past for tinnitus and either was ineffective or in some cases, was shown to have deleterious effects.
In addition to the work being carried out by Hough and Pipeline there is the efforts of Rinri Therapeutics, a UK-based biotech firm founded last year by Professor Marcelo Rivolta! Their focus is also on researching and devising treatments to repair the auditory nerve. Looks promising! https://rinri-therapeutics.com/
Plenty of people here have been knocked back. If you're looking for a mole, I don't think it's going to happen. If I were accepted you wouldn't hear a peep out of me. You've got the NDA, and consider this: Frequency Therapeutics is now a publicly listed company. Any rumour about the current trial will shift the share price. Investors stand to gain or lose millions. I wouldn't want to be on the end of a multi-million dollar lawsuit. How about you?
Don't believe so, most likely maladaptive plasticity the brain trying to fill up the gap in lost hearing due to sudden damage to hair cells by turning up central input. Fix the cochlear damage, the hyperacusis should improve.
Since October when the study opened, I couldn't find anyone to say they were excluded, if that's what "knocked back" means to you.
What's the prevailing scientific consensus on hyperacusis, do you know? Is it said to be due to damage to the OHCs or the auditory nerve and cochlear synaptopathy? Or both? From the research I have done, it seems that a lot of progress has been made over the last decade in identifying the potential underlying mechanisms of hyperacusis and nose-induced pain (noxacusis) in particular.
Call me a heretic, but I think the entirety of tinnitus and hyperacusis originates at the ribbon synapse right at the cochlea in cases of noise damage.
If you're curious you can check out my comment above.
Ok fair enough... lol
Yep. It was me and the other user you mentioned tried to enter the trial and were both rejected due to our audiograms. I got the impression there was a minimum average pure tone loss (or distribution) they were looking for and neither of us qualified.
I've been on the fence about applying because I'd have to drive from Miami to Boca Raton many times. I really wish they had put it down here. I would have applied as soon as it started. I'm still thinking about it.
It was implied, yes. I have 55-60 dB loss at 12000 Hz and mild loss at 250 Hz and nothing in between. I was never tested above 12000 Hz. There seemed to be an average they were looking for. I got no more info than that.
They told me I wasn't a match. I still don't know why not. I mean it's not like I can go back and fake an audiogram to make myself a perfect candidate. I just wanted to know why as I have all the requirements they list they're looking for. But, that's life. I'm just hoping I can hang tough until these drugs come out, at which point mine will have either faded to zero or they will know a lot more.
Maybe it's the way you got it? They're looking for mild to moderate loss due to noise exposure or idiopathic causes. However I feel that many causes get classified under idiopathic for lack of a clearer understanding or lack of the doctor's willingness to find out what was the cause.
What's interesting is they didn't get to that part of the interview before i was disqualified. I might have been disqualified based on that but my audiogram disqualified me first.
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