OTO-413 and OTO-313 have VASTLY different mechanisms of action. OTO-313 is a necessary drug to formulate, as it could be vital to those in the very acute phase to get their hands on an injection that clears the ear of the damaging glutamate flood. I'd be really happy to see a mixture of dexamethasone and OTO-313 for the treatment of acute tinnitus. OTO-413 is geared towards actual restoration than a damage control protocol.
I had one done at my local audiologist. He did up to 20 kHz. I asked him for it and he said sure no problem.
My audiogram was 3 months old - not 6 months - which disqualified me.Sorry, I didn't phrase this correctly. I was wondering if the supporting cells underwent extensive division before being turned into hair cells. From their presentation they said it was one supporting cell dividing one time but their paper implied that they were expanding a single supporting cell many times over. I might be confusing their culture expansions with their hair cell division though, which is why I was hoping someone smarter than me could clarify haha.
From an Audiologist at an Otologist's practice. The ENT didn't have it.
Agree. I can see OTO-313 being very useful acutely. But the question is, how acute is "acute" because it can maybe be problematic after a certain point.
Yes. They are in the business of growing hair cells only. However, every instance that I can recall of a lab claiming success in growing hair cells has included some kind of observation of possible new synaptic connections. It may be an in-built process. Furthermore, a few subjects in the last FX-322 trial achieved very modest improvements in their audiograms but substantial improvements in their word recognition. This suggests (to me, your quintessential layman) some kind of repair beyond increasing the population of stem cells.
Oh, sorry, I'm not that guy haha. Are you saying that the paper may have implied that the drug would act on a singular supporting cell that just performs this same process many times over? If so, I would doubt it. That road sounds like cancer implications. I would think that the drug covers a certain surface area of supporting cells by which all supporting cells in contact with the gel would begin the process of cellular division, though to what level I am unsure. No idea really.
I have much confidence in FX-322 being the real deal. Especially for people with little hearing loss who just need to "fill in the cracks" at the higher frequencies—where the truly nightmarish, high-pitched tinnitus I presume does reside. I'm 28 and the idea of living out the rest of my 20's in the shadow of my former self is so bleak that I'd spring for this treatment at essentially any cost. Safety data isn't the issue here as much as efficacy data is. Although the long-term is understandably unclear, as is with most pharmacological formulations.
That's not a bad place to be in two months following onset, honestly. I'm 27 months in, and I maaaybe got to that point at my sixth month. Even now there are times I feel that way. But it's usually following a spike, be it in noise or anxiety.
Yeah dude, as we saw with ChrisBoyMonkey here. I'm hoping he bounces back but don't wanna tag him and remind him. With so many companies with such unnecessary exclusion criteria, they really should've pulled the reigns on his trauma window IMO. I'd think you have like 1-3 weeks tops for OTO-313. Not exactly easy to recruit people who are still wishing it will go away or are currently being denied even the most basic of steroid therapies by their PCP's. Again, dissemination of information is a huge barrier here.
Check out Neuromod's Lenire. It's the first treatment to work and it's taking appointments. You can even see real life feedback on the User Experiences and Reviews thread.
What about the people that claim an improvement from @R. David Case's noises? What about people like myself that claim curcuminoids lower the volume? Are our experiences invalid because there isn't a company behind what we've done? A clinical trial?
There are also quite of few of us who seemed to get a benefit/reduction in volume from nicotinamide riboside, too.
Is that because you don't consider it to be working or because something got there first. The resuts have been underwhelming to say the least.
No, I think it is working for some just as I sincerely believe @R. David Case's noises work for some.
I suppose it's the first 'commercial' (semi)working treatment solely for tinnitus.
I guess I don't really need to worry about future treatment if it works and I take care. Although I'm more concerned about my ear/facial pain than tinnitus at this stage (which to be fair is quite early)... I wonder if fixing the nerves in the ear will impact comorbid symptoms? Time will tell.
One of the primary objectives of phase 1 was to assess pharmacokinetics. That was likely a big reason for the very low phase 1 dosing. They determined that not much made it systemically, percentage wise, which is why I'm sure they felt comfortable escalating dose.
You don't understand how Lenire works, do you?
Yes he doesn't have the clinical trial or more numbers to back it up. The science of it sounds more on par with Desyncra or Levo, which doesn't seem to work for most, as opposed to Lenire which is more on par with the Michigan device or Minnesota device.
Here is the flip for you, I have a Bachelor's in Marketing and graduated with Veteran Honors.
You don't understand how the English language works, do you?
Thank you for your suggestion, but regretfully Lenire is not available in China
I learned about curcumin from Tinnitus Talk and am ready to try it，but I don't know if it is effective for tinnitus caused by hearing loss.
It's not available in the United States yet but I'm flying over to Ireland for my first appointment very soon! It's just another option to look at if you can find the money for the flights and treatment costs.Thank you for your suggestion, but regretfully Lenire is not available in China
Thanks for the reply
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