FX-322 is a progenitor cell activator and stimulates supporting cells to form outer hair cells and (it seems) inner hair cells. If you have OHC cell issues, usually this would show up on an extended audiogram unless you have a "notch." IHC loss is hard to diagnose. FX-322 likely won't work on losses below 3500 Hz yet (a version 2.0 likely would). It also generally wouldn't treat issues in the synapse unless you happen to be missing an IHC there too.
I have zero doubt an updated later formula won't address those. They appear to be hiring formulations scientists.
Sorry to be nitpicking, but that sounds like a double negative. The meaning of which is ambiguous. It can only be either one of the following.
I mean I am confident and without doubt that a later formulation will address the issue. I'm in agreement with you.
Thank you for your insight. I'm new to hearing loss and greatly appreciate yourself and others breaking this cutting edge stuff down.
If your audiogram is still improving, you might not need regenerative medicine. Inflammation can take a long time (many months) to resolve.
About halfway into the concert that caused the trauma I had my jacket draped over my ears to help muffle the sound in lieu of no earplugs (shoulda left or brought ear plugs in the first place, believe me I know now). I believe the left ear just got firmer coverage than the right. It was an incredibly bass-heavy metal band in a small venue. Not sure if that explains the low frequency loss.
@patorjk told me that companies can actually release drugs out in the market in Phase 3. If Frequency Therapeutics go directly to Phase 3 after Phase 2a it could be possible for them to release it next year.
It is definitely not decades away. My guess is 2-5 years but if they can somehow skip phase 3, possibly sooner.
Oddly enough, noise induced hearing loss doesn't necessarily happen in the frequencies with the most amplitude. It has a lot to do with the mechanics of the ear and how the energy is transferred across mediums, but noise induced hearing loss usually shows up between 3 kHz and 6 kHz. 500 Hz is much lower than that and shouldn't cause a "lack of clarity" feeling. I'm down about 35 -40 dB everywhere below 1 kHz (1000 Hz) and the best way I can describe it is that everything I hear through that ear sounds like it's played through an iPhone speaker. It's clear, but it's "tinny" sounding.
Well whatever Frequency Therapeutics is cooking hopefully it helps us with hyperacusis.Okay, so I was curious about the implications of OHC regeneration and hyperacusis and did some further digging on this forum. A few years ago a user @Soren ) actually contacted one of the researchers who was involved in the study showing that the type 2 nerve fibers in the inner ear act as pain receptors (Jamie Garcia-Anoveros at Northwestern). They asked him whether repairing the OHCs would solve painful hyperacusis and it seems like it might not be the correct fix. This was the reply he got:
"The problem with pain hyperacusis is that it is not triggered by damage to OHCs. Type IIs respond to this damage normally, and this is appropriate. Pain hyperacusis sufferers feel the pain to non-harmful sound levels. The hypothesis is that the normal pain system of the type II afferents has been sensitized, so that they now become active in response to the vibrations caused by normal sounds. This is akin to what happens in some cases of neuropathic pain, when damaged pain fibers (elsewhere in the body) are active in response to light touch, so that this becomes painful (this is called allodynia). So, the solution would probably not be to replace the OHCs, but to silence the type II afferent neurons."
https://www.tinnitustalk.com/threads/frequency-therapeutics-—-hearing-loss-regeneration.18889/page-54#post-356547
Interesting although I guess at the moment everything is still sort of speculative. So I'm still hopeful that therapies like FX-322 could impart some sort of benefit for hyperacusis but I guess it's just so complicated.
Yeah, there was also the anecdote from the Regain guy who reported that his tinnitus and hyperacusis improved. I don't know. I mean tinnitus and hyperacusis arise most of all due to trauma and damage to the inner ear and it seems like FX-322 basically sets in motion a healing cascade so I'm going to remain hopeful.
I think it could definitely benefit loudness hyperacusis but I'm not sure how pain hyperacusis would be addressed by these therapies. I would think OHC repair could prevent further hyperexcitability to the nerve and maybe over time that could allow recovery.Okay, so I was curious about the implications of OHC regeneration and hyperacusis and did some further digging on this forum. A few years ago a user @Soren ) actually contacted one of the researchers who was involved in the study showing that the type 2 nerve fibers in the inner ear act as pain receptors (Jamie Garcia-Anoveros at Northwestern). They asked him whether repairing the OHCs would solve painful hyperacusis and it seems like it might not be the correct fix. This was the reply he got:
"The problem with pain hyperacusis is that it is not triggered by damage to OHCs. Type IIs respond to this damage normally, and this is appropriate. Pain hyperacusis sufferers feel the pain to non-harmful sound levels. The hypothesis is that the normal pain system of the type II afferents has been sensitized, so that they now become active in response to the vibrations caused by normal sounds. This is akin to what happens in some cases of neuropathic pain, when damaged pain fibers (elsewhere in the body) are active in response to light touch, so that this becomes painful (this is called allodynia). So, the solution would probably not be to replace the OHCs, but to silence the type II afferent neurons."
https://www.tinnitustalk.com/threads/frequency-therapeutics-—-hearing-loss-regeneration.18889/page-54#post-356547
Interesting although I guess at the moment everything is still sort of speculative. So I'm still hopeful that therapies like FX-322 could impart some sort of benefit for H but I guess it's just so complicated.
Yeah, one of the studies from 2016 into the type 2 pain receptors showed that using a potassium channel modulating drug, Retigabine, silenced the type 2 nerve fibers. So what Thanos Tzounopoulos is doing by reformulating it (into RL-81) could very well also prove beneficial for noxacusis. Hyperacusis Research appears to be primarily focused on noxacusis so progress is being made.
I can say with complete certainty and seriousness that this factor will play a major role in some tinnitus sufferers' fate of life or death.
Thank you, the info is greatly appreciated. The clarity issue seems to be very pronounced in hearing my own voice, although I definitly notice everything else is a touch fuzzier too. When I speak it's as if my left ear picks up more of my voice, and clearer than the right. It's extremely noticable with the letter S. It's almost like the left ear steals that letter away from the right. I seem to image more sound traveling to the left, if that makes sense. When I cover my right ear and speak, I hear my voice sharp and clear out of the left. When I cover my left ear and speak, my voice is muddier and overall less of it seems to go around my head and reach the right ear.
I had the crackling for months accompanied by a "rice crispies" feeling. No idea what it was. It just disappeared one day.
They asked an otologic surgeon, not a researcher. I wouldn't take that quote too seriously. My first otologist *literally* wrote the otology surgery textbook and hadn't even heard of Frequency Therapeutics (this was post phase 1 results even).
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