Frequency Therapeutics — Hearing Loss Regeneration

[Paulmanlike]

There isn't a biological cure for ANY hearing loss at present.

 

[Iliasp]

Thank you for your reply, which one of them is?

There are many articles online, but still nothing yet available

 

[grate_biff]

Please get a move on Frequency. I´m dying here

 

[acufenero]

Please get a move on Frequency. I´m dying here

The world kinda stops in summer, so I wouldn't expect any news until September at least. Anyway, what are you expecting from them? I don't think they will share any detail of the trial anytime soon since it's still one year away from now. Their next big thing is their second paper that's scheduled for later this year.

 

[JRchief]

Anyway, what are you expecting from them?

my guess...i think we are all simply hoping they make it through clinical trials with some level of success in restoring hearing. if your T is related to hearing loss, then restoring hearing on some level may help with your T. it won't help everyone but it may help some of us.

my summer relief is listening to the cicadas chirp at night getting lost in the sound.

 

[Reinier]

Please get a move on Frequency. I´m dying here

I think it is more difficult to be patient when things seems to be moving.
That things (research) are moving is my impression at least. But I am relatively new to these hearing issues. ("only" two years).

 

[grate_biff]

I think it is more difficult to be patient when things seems to be moving.
That things (research) are moving is my impression at least. But I am relatively new to these hearing issues. ("only" two years).

You are quite right!
When you are suffering as much as we do. The awareness of something, to maybe ease the pain, is "brewing" makes it hard to be patient.
The drug is already there. I want it. And I want it now.
Even if it does not work, I´ve tried!

 

[grate_biff]

So what drug would you like to try, If you had the opportunity

FX-322!!!!

 

[Reinier]

Even if it does not work, I´ve tried!

Just don't underestimate what can go wrong.

When drugs change the inner ear this could be something that is irreversible.
Perhaps even likely. That then is a dead end.

I am glad that researchers are very cautious when it relates to clinical trials.
Despite the predicament I am in, I would not be keen to subject my ears to a drug that is still in clinical trials.
When I was in the early stages of my hearing problems "journey" I was more perceptible for desperate measures.

 

[cornelius]

Just don't underestimate what can go wrong.

When drugs change the inner ear this could be something that is irreversible.
Perhaps even likely. That then is a dead end.

I am glad that researchers are very cautious when it relates to clinical trials.
Despite the predicament I am in, I would not be keen to subject my ears to a drug that is still in clinical trials.
When I was in the early stages of my hearing problems "journey" I was more perceptible for desperate measures.

Ok but never underestimate the lying ability that is widespread among drug makers and physicians. Even hidden defect that were found during trials can be hidden once the drug is sold on the market. I had horrific side effects without any improvement when an ent prescribed me vasodilator pills and with his sardonic smile he told that side effects don't exist. It was 15 years ago and now I can't wait for the second round, with two new allies : the fact that reviews are now widespread on the internet, and that the upcoming paradigma is slowly admitting that pills will never fix anything

 

[Reinier]

the fact that reviews are now widespread on the internet

I hope the same will be the case for clinical trials. I realise that initially people that are subjected to these trials are not allowed to comment in order to not disrupt these trials. But eventually information will end up on the internet.
(Also plenty (or even more) speculation and disinformation ).

and that the upcoming paradigma is slowly admitting that pills will never fix anything

Do you think that hair cell regeneration research/trials relates to this paradigm, or do you mean something else with pills?

 

[cornelius]

I hope the same will be the case for clinical trials. I realise that initially people that are subjected to these trials are not allowed to comment in order to not disrupt these trials. But eventually information will end up on the internet.
(Also plenty (or even more) speculation and disinformation ).

Do you think that hair cell regeneration research/trials relates to this paradigm, or do you mean something else with pills?

From what I remember on old tinnitus-hearing loss- hyperacusis forums and testimonies fifteen years ago, apart from corticoids injections which could be very effective in the case of acute inner ear noise traumatism if taken immediately, many tinnitus, hearing loss and hyperacusis sufferers were prescribed :
- Vastarel, now still on market but no more allowed for tinnitus treatment if I am not mistaken
- Rivotril, still on market, but now known as as addictive as heroin and alcool with painful, sometimes deadly taper, I have read horrific testimonies from severe tinnitus and hyperacusis sufferers becoming zombies at the same time as keeping severe tinnitus and hyperacusis, and doctor continuing prescribing it like candies
- Piracetam, ending of reimbursement due to side effects and relative inefficiency and weak profitability as well
- along with similar vasodilators and benzodiazepines
And I haven't seen anybody objectively satisfied yet

Moreover, some clown doctors called Tinnitus Experts swaggered tinnitus is not a fatality and rarely overtakes 5 decibels and that the bright future is in behavioural therapies ! 2017 is still tough but nevertheless more serious than 2002

 

[jer]

http://www.medindia.net/news/drug-c...ir-cells-can-combat-hearing-loss-168074-1.htm

 

[missingsilence]

Is this targeting inner ear hair cells, the auditory nerve or the synapses?

 

[EatMoTacos]

Is this targeting inner ear hair cells, the auditory nerve or the synapses?

I believe so. Not too sure. Maybe others can comment on this.

 

[missingsilence]

I believe so. Not too sure. Maybe others can comment on this.

I'm not entirely sure either, however from what I read it seems like it's hair cells only.

 

[Aaron123]

Is this targeting inner ear hair cells, the auditory nerve or the synapses?

Hair cells. The hope is that synapse will form for the new hair cells, but it will not repair damaged synapses or the AN.

 

[jer]

As far as i know, they are talking about targeting the inner ear hair cells here.

 

[jer]

Another very nice article that goes quite in depth. http://www.medindia.net/news/drug-c...ir-cells-can-combat-hearing-loss-168074-1.htm

 

[jcloth]

Not much in the way of new info but there's a new Bloomberg video segment at the bottom of this page http://www.frequencytx.com/community/community-resources.php

 

[Paulmanlike]

Not much in the way of new info but there's a new Bloomberg video segment at the bottom of this page http://www.frequencytx.com/community/community-resources.php

Grrr why didn't he ask him about tinnitus. If all this hope about curing hearing loss is all well and good and looks inevitable but we want to know if they predict it will fix tinnitus

 

[Telis]

Part of the problem (for myself, and many others) is that you can't hear properly over your tinnitus, if your hearing were new again you could, tinnitus would be a pretty minor issue at this point, just turn on a little background noise and use your newly refurbished ears to detect sounds over your tinnitus that you couldn't previously hear. Would be very easy to mask with good hearing.

Having said that, Im pretty sceptical about a hearing loss restoration drug ever even being possible, if we were even close, the dollars would follow. It's a very high risk, low probability venture, otherwise you would see billions of dollars backing new projects, not just a few small companies with minimal backing. Just my option, I hope to be wrong.

 

[Amiel]

Part of the problem (for myself, and many others) is that you can't hear properly over your tinnitus, if your hearing were new again you could, tinnitus would be a pretty minor issue at this point, just turn on a little background noise and use your newly refurbished ears to detect sounds over your tinnitus that you couldn't previously hear. Would be very easy to mask with good hearing.

Having said that, Im pretty sceptical about a hearing loss restoration drug ever even being possible, if we were even close, the dollars would follow. It's a very high risk, low probability venture, otherwise you would see billions of dollars backing new projects, not just a few small companies with minimal backing. Just my option, I hope to be wrong.

Buy hearing aids.

 

[Rubenslash]

Part of the problem (for myself, and many others) is that you can't hear properly over your tinnitus, if your hearing were new again you could, tinnitus would be a pretty minor issue at this point, just turn on a little background noise and use your newly refurbished ears to detect sounds over your tinnitus that you couldn't previously hear. Would be very easy to mask with good hearing.

Having said that, Im pretty sceptical about a hearing loss restoration drug ever even being possible, if we were even close, the dollars would follow. It's a very high risk, low probability venture, otherwise you would see billions of dollars backing new projects, not just a few small companies with minimal backing. Just my option, I hope to be wrong.

All companies are in a preclinical stage, of course it's not yet attracting billions. I am impressed by the amount of money Frequency FX has already raised from institutional investors.

 

[Joe J]

Once they have a proven model. The money will flow in like crazy. Especially from the government because tinnitus is expensive as fuck in terms of disability claims for veterans.

 

[Flamingo1]

This is a better link IMO

 

[VRZ78]

Don't know if anyone noticed but the end date of frequency tx trial has been pushed back from mid August to mid November due to delay in recruiting patients. They also added one participants to their target size.

 

[Paulmanlike]

How will we know if it works if they are receiving the injection just prior to cochlear implant? Sure it takes time for the molecules to activate PCA? Isn't this just to measure how much of the drug reaches the cochlear?

 

[Mentos]

Part of the problem (for myself, and many others) is that you can't hear properly over your tinnitus, if your hearing were new again you could, tinnitus would be a pretty minor issue at this point, just turn on a little background noise and use your newly refurbished ears to detect sounds over your tinnitus that you couldn't previously hear. Would be very easy to mask with good hearing.

Having said that, Im pretty sceptical about a hearing loss restoration drug ever even being possible, if we were even close, the dollars would follow. It's a very high risk, low probability venture, otherwise you would see billions of dollars backing new projects, not just a few small companies with minimal backing. Just my option, I hope to be wrong.

Well @Telis you probably saw that Google bought into Decibel Tx
http://www.businesswire.com/news/ho...s-Announces-Investment-GV-Expand-Capabilities

I know it would be awsome to have more big companies investing in this field but I can't agree that Google Ventures is a small company with minimal backing.

 

[VRZ78]

How will we know if it works if they are receiving the injection just prior to cochlear implant? Sure it takes time for the molecules to activate PCA? Isn't this just to measure how much of the drug reaches the cochlear?

Yes it's a phase 1 trial, the goal is only to know how much of the drug goes into the cochlea and into the blood stream.