Maybe we should see if we can make a FAQ that explains what medications in the most popular research threads do (e.g. FX-322 regrows OHC and IHC, this is found as a hearing loss on an audiogram etc.)? Then it could be pinned on the main research board whichould reduce redundant comments plus increase scientific understanding among patients.
I don't think damage to the stria vascularis will affect the efficacy of FX-322 in any way, but damage to the stria vascularis will continue to affect your hearing after hair cell regeneration and resynapsing though.
Wouldn't Frequency Therapeutics be capable of making a supporting cell "multiplicator" rather easily? If they can divide supporting cells into a supporting cell that transdifferentiates into a hair cell and leaves a copy behind, surely they're capable of making a solution that just divides supporting cells into multiple supporting cells? It would seem that this is one of the easiest problems to solve?
.
You're absolutely right and even then it is still an inadequate test. In my opinion all hearing tests are archaic and insufficient. By the time something shows up on an audiogram there is probably already extensive damage. It's kinda sad to see people say they have perfect hearing, because their ENT said so. Wavering their audiogram around with 10 measuring points or 18 if they were smart enough to do an extended audiogram (which is still only 0,0009% of the spectrum).
This is depressing as fuck to me. I could handle the intrusive tinnitus, the loss of my career, the dissolution of my marriage and the visual snow if I could just get music back. I *constantly* grieve for its loss. And as it stands now all music sounds muffled and distorted. If this is the result of severe stria damage (which Azithromycin in particular is known to do), I don't even know what to hope for anymore.
Sorry to hear this. Really would have been awesome to have an insider.
All you had to do was miss at least 15% of the words to get the magic candy. How hard can that be? 
If the tinnitus is generated due to basic cochlear damage resulting in some form of maladaptive neuroplasticity, then it's very plausible in my opinion that this neuroplasticity will be reversed when the damaged frequencies are restored. Nobody is sure however until we get there.Thank you for your answers.
@FGG If I understand correctly, restoring hearing will reduce or eliminate tinnitus, is that for sure?
An ORL in France told me that once the acute period ended, the tinnitus was ingrained in the brain. There was nothing to do except to get used to it.
By restoring the OHCs and IHCs, the FX-322 will reduce or eliminate tinnitus. Therefore, to have the cochlea repaired, we combine the FX-322 with another treatment that repairs the synapses as you said and at that time, we should no longer have tinnitus, is that right? You just have to wait 10 years
We actually have that here, but it's not a sticky. Nor is it up to date.
There's no doubt for a certain amount—I'd even argue for a majority of sufferers, that this will be the case. We see it with people that have damaged frequencies in the hearing aid range - they pop them in, boom, instant tinnitus relief.
This is really informative and perhaps ties in with hyperacusis given that one of the key symptoms is a collapsed dynamic range.
I can attest to the fact that losing music can be absolutely devastating to your psyche, because for the first two months post-accident my hyperacusis was so bad I could not listen to anything. There are still bands/songs I cannot listen to, but this is only due to pain resulting from the signal relay and not due to the distortion of the sound itself. I cannot fully empathize with you, but I have felt this in the past.
FGG
I wish there was something I could do for you.
Then is it safe to assume that if music is not distorted after acquiring tinnitus from ototoxin that the stria vascularis has not been damaged?
I believe tinnitus can arise anywhere along the auditory pathway where there is abnormal neuronal activity that is interpreted by the brain as an auditory signal. Best example is neck injuries causing tinnitus. It's because of physical pressure on the intermediary nuclei in the auditory pathway. It simply proves that tinnitus doesn't have to start or arise in the cochlea. Obviously in that particular case we're speaking of somatic tinnitus which can normally be relieved or alleviated by physiotherapy.
I can only speculate on what the exact impact is of damage to the stria vascularis. I know it is an essential supporting function required to make hair cells function. Hair cells can be perfectly intact, but will do nothing if the stria vascularis doesn't work. They will simply not generate the action potential and therefore not send any signal to the spiral ganglion cells.
I feel for you, pretty much everything in my life for the past 20 years has revolved around music or sound in some manner.
See I thought this too about pain hyperacusis - that it's triggered by damage to OHCs which in turn activates the nerve fibers thus solving the problem = fixing OHCs but I'm not so sure. I did some digging and a few years ago someone got in touch with one of the researchers from Northwestern, Jaime Garcia-Anoveros, who produced the study into the pain receptors in the cochlea, asking about this. He said that:
I disagree. That actually is not what I mean to suggest. That list is too jargon heavy for most people to understand. To be fair, FAQ is definitely the wrong term. I think a very simple and plain description of what the drug will fix and how to best tell if that is your problem is much more useful than knowing how the drug is administered, what the chemical is called, what the mechanism is, etc.
I'm worried too that this won't work for pain hyperacusis. I really hope that FX-322 works for us with pain hyperacusis but also loudness hyperacusis.
We talked about this a few pages back but never saw the exact classification termed "Breakthrough Therapy." Very cool, thank you for the source. Possibly something to amend in the letter to Dr. Woodcock, @FGG?
Do you have any sources on the stria and how it affects music? All I am finding so far is that, in addition to ototoxicity, stria damage and atrophy seems related to age-related hearing loss and the loss of endocochlear potential seems to not only cause hair cell damage over time, it apparently seems to produce audiogram changes as well.
Member
