Frequency Therapeutics — Hearing Loss Regeneration
- Thread starter RB2014
- Start date
Member
- May 7, 2015
- 1,051
- Tinnitus Since
- 29.09/2014
- Cause of Tinnitus
- Acoustic trauma using headphones
Andrei90
Member
- Dec 12, 2017
- 154
- 34
- Tinnitus Since
- 12/2017
- Cause of Tinnitus
- Exposure to loud music (earphones)
Is there an explanation for why hearing aids sometimes work? The theory behind it makes sense and does work for some people but why not others? Is there something else at play here?
Well, some forums members here wrote about this theory. Is this supported by professionals or do they reject the opinion that frequency's approach could help with tinnitus? Every doctor here say's it's in the brain. Of course we all hope that it's an easy fix. If tinnitus is generated in the brain and the cause is the ear, then it's all good, because fixing the brain is not understood and frequency could help, but how do people with more insight think about fixing tinnitus by regenerating hearing? Does anybody have read papers about that theory or is it just a tinnitustalk thing, people coming together, sharing hope? I hope I'm not shattering dreams here, being too negative -- I'm betting on them too, that's all I can do.
A phase 1 trial focuses on safety. In most cases efficiency is not monitored.
Patients from the clinical trial had cochlear implant surgery just after the procedure, so efficiency couldn't be measured anyway. We have to wait for phase 1b/2 for this.
- Nov 6, 2017
- 177
- Tinnitus Since
- 26-9-2017
- Cause of Tinnitus
- Unknow possibly noise trauma
I don't think we Can expect efficacy from people with such severe hearing loss. I'm glad it's safe. Those people are my heroes for sure. Take an injection in the ear whit knowing for sure it will do nothing for your hearing, maybe destroy your cochlea completely So CI won't work. Much much respect.
- Apr 15, 2017
- 1,419
- Tinnitus Since
- 2008
- Cause of Tinnitus
- Noise
There are only theories to why hearing aids work to reduce tinnitus (the actual sound). i read an interesting article to why this is, something like if the frequency lost is between a certain kHz then there's a chance a hearing aid might help tinnitus but in other frequencies it won't help reduce the actual tinnitus.
I wish I had the link to show you as to be more precise.
@HomeoHebbian I don't think is too convinced hair cell regeneration will work, while other researchers are more confident.
Tinnitus is still very much a phenomenon, we need to remember that. We can't see it, nobody else can hear it and we are not even sure where exactly it comes from.
One thing for sure though is that if hair cell regenerations does not work for tinnitus we have other promising avenues (signal timing, xen 11-01 and somebody recently spoke about a new antidepressant drug that is being developed that targets the hippocampus that may help tinnitus (another theory that tinnitus is generated in there)
"the high unmet need and high prevalence of tinnitus is only going to drive the development of new treatments"
I think that the origin of tinnitus, in the vast majority of cases, is in some ear dysfunction, along with other circumstances to be known. That change of signal input through the ear, generates changes in brain neurons, due to its plasticity, causing tinnitus. the return to the previous situation in the ear, how can be a hearing aids or the restoration of the lost signal, it is possible that it returns to the neurons to its initial state. that is why many times hearing aids improve tinnitus. and that is why the restoration of the hearing will most likely improve or eliminate the tinnitus in many cases. I do not have the slightest doubt. and once the tinnitus diminishes very possibly the very easy habituation, and the part of the hippocampus and amygdala will do the rest of the work, forgetting about the tinnitus .opino que el origen del tinnitus, en la inmensa mayoría de los casos, se encuentra en disfunción del oído, junto a otras circunstancias por conocer. Ese cambio de entrada a través del oído, cambios en las neuronas cerebrales, debido a su plasticidad, provocando el tinnitus. la vuelta a la condición previa en el oído, cómo puede ser audible o la restauración de la pérdida de la señal, es posible que retorne a las neuronas a su estado inicial. es por eso que muchas veces los audifonos mejoran el acúfeno. y es por ello que la restauración de la audición es muy probable que mejore o elimine los riesgos en muchos casos. a mí no me cabe la menor duda. y una vez que disminuyó el tinnitus muy posiblemente la habituación muy fácil, y la parte del hipocampo y amígdala fue el resto del trabajo, olvidándose del tinnitus
While Frequency trial is just phase 1 with primary objective to assess safety I wonder why assumption is that hearing cannot improve for those who undergo CI(and assuming the drug is effective). CI electrode will certainly damage remining hair cells, but to my understanding not all, because it doesn't reach very end of cochlea and assuming that drug reach this part in theory we should observe improvement in low-pitched sounds.
I am not a Neuroscientist, but I am confident any healing of the hearing mechanism will help reduce the perception of T. I have a few reasons for believing this.
1. Hearing aids help diminish the perception of T due to the amplification of lost frequencies.
2. The brain, although maybe stuck in a "loop" state, is STILL searching for the missing input, hence the T.
3. How quickly did your brain adapt to your loss of hearing with the appearance of T? My guess is pretty quickly.
1. Hearing aids help diminish the perception of T due to the amplification of lost frequencies.
2. The brain, although maybe stuck in a "loop" state, is STILL searching for the missing input, hence the T.
3. How quickly did your brain adapt to your loss of hearing with the appearance of T? My guess is pretty quickly.
Approximately one month after loud event, my tinnitus and other issues like hyperacusis and distortion started.
I do not believe that is because of plasticity of the brain.
You don't think a month is quick?
I will take the intratympaic injection today if it takes a whole year for it to improve my T. I don't cRe how long it takes, provided it works.
Read up on it here.
"Short-term synaptic plasticity acts on a timescale of tens of milliseconds to a few minutes unlike long-term plasticity, which lasts from minutes to hours."
4. Aspirin at high doses, which causes temporary moderate hearing loss, also causes temporary tinnitus (and hyperacusis): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341117/
5. Most people experience tinnitus after spending a few minutes in a soundproofed room, presumably due to lack of acoustic input.
Since T. is connected to the brain, and possibly that the T. has created neuron connections which makes the current T. sound and is no longer connected to your damaged hair cells, but just isolated in your brain. How will new hair cells cure this?
I guess that's like asking how tinnitus goes away along with hearing loss associated with a high dose of aspirin, or how it goes away after emerging from a soundproofed booth. The brain is producing the sound but when input is restored the brain stops doing this. I'm sure that there are a few different mechanisms for chronic tinnitus but I think it's plausible that a significant one is an ongoing lack of input because of hair cell and synapse damage and that it is reversible if that damage can be repaired.
Your brain is CONSTANTLY monitoring input that you are not consciously aware of.
There is also the theory that what us T'ers are hearing is the firing of the damaged hair cells all the time. So if they are repaired, they dont fire unless directed to (resonating at the correct frequency in response to input) and T goes away.
This is all wishful thinking, but there is evidence there to be hopeful.
There is also the theory that what us T'ers are hearing is the firing of the damaged hair cells all the time. So if they are repaired, they dont fire unless directed to (resonating at the correct frequency in response to input) and T goes away.
This is all wishful thinking, but there is evidence there to be hopeful.
- Apr 23, 2015
- 418
- Tinnitus Since
- 01/21/2014
- Cause of Tinnitus
- High frequency hearing loss in left ear from head trauma (?)
As usual, acute T will have a better chance to be cured because fixing the hair cells might be enough. Chronic tinnitus has other complications like the hair cell associated neurons might be gone after a few months of T onset.
Isn't frequency therapeutics working for those that have chronic tinnitus and hearing loss not just acute ?
- Nov 6, 2017
- 177
- Tinnitus Since
- 26-9-2017
- Cause of Tinnitus
- Unknow possibly noise trauma
They are not working on tinnitus. It might be a side effect. Positive or negative. No one knows.
The problem is that the medicine will not cure the damaged HC but create new one.
I hope that whoever tooks this innovative medicine will post very soon the effect
Does anyone have any idea what happens with the damaged hair cells with frequency's approach? I understand they are using progenitor cells (whatever that means) but what about the ones that are actually damaged? Will they remain damaged and then will there be new hair cells next to them? How do we know that the damaged ones STILL won't be causing issues such as Tinnitus and Hyperacusis? Or is frequency's approach actually HEALING the current damaged cells? This has not be clarified anywhere at all and has been highly frustrating to get some proper answer to. It is probably one of the single most important questions in regards to this approach.
I literally asked one of the founders few days ago, go back few pages. He didn't disclose a lot of information tho.
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