Frequency Therapeutics — Hearing Loss Regeneration

[Born To Slay]

What I'm worried about is health care providers not prescribing/recommending the treatment for those with tinnitus, but whose hearing tests come back fine. We all know that they don't tell us everything...

But that's a worry for the future.

Aren't they checking for tinnitus in phase 2a? If so, maybe it'll be approved also for tinnitus.

Side note: I feel mean for saying this but I can't wait for audiologists to all go out of business xD

 

[Lucifer]

Aren't they checking for tinnitus in phase 2a? If so, maybe it'll be approved also for tinnitus.

Side note: I feel mean for saying this but I can't wait for audiologists to all go out of business xD

Yes well it was bound to happen. I just hope more audiologists are wanting regenerating hearing medicine to come out than those who are bitching about losing profits since hearing aids will become obsolete.

 

[Born To Slay]

Yes well it was bound to happen. I just hope more audiologists are wanting regenerating hearing medicine to come out than those who are bitching about losing profits since hearing aids will become obsolete.

It's honestly barely even a real profession. They don't know shit about hyperacusis or tinnitus and give actively dangerous advice.

 

[Lucifer]

It's honestly barely even a real profession. They don't know shit about hyperacusis or tinnitus and give actively dangerous advice.

Once hearing regeneration medicine comes out Audiologists and ENTs better be more informed about tinnitus and hyperacusis.

 

[Born To Slay]

Once hearing regeneration medicine comes out Audiologists and ENTs better be more informed about tinnitus and hyperacusis.

I meant they'll kind of have to be, I'm sure it'll be front page news when tinnitus is cured. Like right now we are the only ones that follow this but I'm sure when this trial is done and they announce the results that they just cured fucking hearing loss and tinnitus, one of the greatest medical breakthroughs in history, I'm sure it'll be all over.

 

[tommyd87]

Yes well it was bound to happen. I just hope more audiologists are wanting regenerating hearing medicine to come out than those who are bitching about losing profits since hearing aids will become obsolete.

Audiologists and the hearing aid companies will bitch like the taxi companies did here when Uber made them almost obsolete. I am almost certain they will try to disrupt and delay this as much as they can.

 

[Born To Slay]

Audiologists and the hearing aid companies will bitch like the taxi companies did here when Uber made them almost obsolete. I am almost certain they will try to disrupt and delay this as much as they can.

I'm sure they will but ultimately they don't have a lobby and I'm sure the government can't wait for this to come out with all the hearing damage sustained in the military and all the people on disability as a result.

 

[Born To Slay]

Hey guys, so I'm reading that FX-322 didn't improve audiogram results. Is this true and if so, how can it be a cure for hearing loss?

 

[ASilverLight]

Audiologists and the hearing aid companies will bitch like the taxi companies did here when Uber made them almost obsolete. I am almost certain they will try to disrupt and delay this as much as they can.

I doubt they would have much to stand on, honestly. This would be a major medical breakthrough.

Like @Born To Slay says, everyone would be dying for this to come out because in the long run it will save any government a lot of money otherwise spent on this specific care.

 

[xyz]

So I think there's 3 things going on here.

1.) COVID-19 has slowed things down in general

2.) Frequency is looking for a very specific level of hearing loss where FX-322 will shine

3.) The older you are, the more likely you have hearing issues. Older people are more at risk with covid so this would make it even more difficult to find willing patients...

Also, and this just my opinion, but I think Frequency has every incentive to get this drug approved as quickly as possible. They are part of the market, and as such, they have competition and also accountability to shareholders.

The same cannot be said for the FDA.

I don't think Frequency has a lot of competition. It would be better if there were more labs working on this inner ear regeneration thing. Otonomy has something in preclinical phase for hair cell regeneration. Audion, we really don't know what they are actually doing. I have a feeling Frequency could start playing PlayStation for the next 3+ years and would still be ahead in this business.

 

[FGG]

Hey guys, so I'm reading that FX-322 didn't improve audiogram results. Is this true and if so, how can it be a cure for hearing loss?

They improved at 8kHz. Since they are testing extended frequencies in this trial, they should see improvements up to the tested UHF frequencies.

 

[Lola808]

Is there any way to convince Frequency Therapeutics to test for hyperacusis in their next trial? I know tinnitus is on the rating list to see how it's affected. I would like to know more about hyperacusis too. As many/many of us have both.

Can we write them or petition? Just thinking out loud.

 

[serendipity1996]

Is there any way to convince Frequency Therapeutics to test for hyperacusis in their next trial? I know tinnitus is on the rating list to see how it's affected. I would like to know more about hyperacusis too. As many/many of us have both.

Can we write them or petition? Just thinking out loud.

I wonder if Hyperacusis Research would know anything about this and whether they're aware of any clinical trials that will also be taking hyperacusis into account.

 

[Born To Slay]

They improved at 8kHz. Since they are testing extended frequencies in this trial, they should see improvements up to the tested UHF frequencies.

Ah okay, awesome. I was pretty depressed for a second there lol. Thanks for answering shit for me btw, I'm kinda late to the party here because I didn't think that I had hearing loss so I didn't think it'd help but it turns out I do.

 

[AtlasFainted]

I don't think Frequency has a lot of competition. It would be better if there were more labs working on this inner ear regeneration thing. Otonomy has something in preclinical phase for hair cell regeneration. Audion, we really don't know what they are actually doing. I have a feeling Frequency could start playing PlayStation for the next 3+ years and would still be ahead in this business.

3 years of profits is a massive amount of money, I doubt they'd leave that on the table.

Frequency does have competition, there are other biotech labs that aren't far behind.

Even things like hearing aids (we use these to speculate on what the cost of FX-322 will be) and upcoming synaptopathy drugs will be cutting into their market.

They have every reason to get their product out quickly, and continue to improve it in order to stay ahead.

 

[tommyd87]

I doubt they would have much to stand on, honestly. This would be a major medical breakthrough.

Like @Born To Slay says, everyone would be dying for this to come out because in the long run it will save any government a lot of money otherwise spent on this specific care.

Not at al. I am almost certain that there will still be whinging which will happen essentially anytime an actual change in a business happens. Hell this won't be any different but basically it is still going to happen. I will just really roll my eyes.

 

[serendipity1996]

Is there any way to convince Frequency Therapeutics to test for hyperacusis in their next trial? I know tinnitus is on the rating list to see how it's affected. I would like to know more about hyperacusis too. As many/many of us have both.

Can we write them or petition? Just thinking out loud.

Hope you don't mind me double-quoting you but I was reading about a proposed bill in the US, the Promising Pathways Act which aims to accelerate drug approval and to enable pharmaceutical companies to petition the FDA for provisional approval if the drug has proven safety in early-stage clinical trials. It's an initiative that has evolved as a response to ALS advocacy groups but this legislation is targeted at terminal and critical conditions and those that are severely debilitating. This feels encouraging to me - we all know how severely tinnitus and hyperacusis can impact quality of life at their worst and even hearing-loss in itself is a risk factor for cognitive decline and dementia.

https://www.braun.senate.gov/senato...way-act-patients-serious-and-life-threatening

 

[Lucifer]

Is there any way to convince Frequency Therapeutics to test for hyperacusis in their next trial? I know tinnitus is on the rating list to see how it's affected. I would like to know more about hyperacusis too. As many/many of us have both.

Can we write them or petition? Just thinking out loud.

If they do test for hyperacusis they have to be more specific. They need to test patients with both pain and loudness hyperacusis.

I still believe that FX-322 can do the same thing as what Audion did to improve the musician's hyperacusis. I still have no clue which hyperacusis he had though.

 

[ASilverLight]

The majority with tinnitus probably has HF hearing loss (considering so many have clean hearing tests) or hearing loss at frequencies not even tested in extended audiograms. I do have hopes for this medication.

 

[patorjk]

Looking at the charts in eTrade, it looks someone (or some company) made a trade of 139.5k shares after hours, and there have been a number of big trades this week. In fact, it looks like this week represents the biggest week as far as trade volume is concerned. Anyone have any insight into what is going on? Maybe hedge funds are buying shares?

 

[Diesel]

I wonder if Hyperacusis Research would know anything about this and whether they're aware of any clinical trials that will also be taking hyperacusis into account.

I think the outcomes of the two hearing assessments; The Hearing Handicap Inventory for Adults and Hearing Screening Inventory will give us an indication if hyperacusis symptoms improved. Many of the questions directly relate to the experiences/lifestyle changes people with hyperacusis experience.

Otherwise, they're doing the Loudness Discomfort Level... I'm not sure they'll want to test LDLs in patients with fresh new hair cells... or maybe they would?

 

[AtlasFainted]

Hope you don't mind me double-quoting you but I was reading about a proposed bill in the US, the Promising Pathways Act which aims to accelerate drug approval and to enable pharmaceutical companies to petition the FDA for provisional approval if the drug has proven safety in early-stage clinical trials. It's an initiative that has evolved as a response to ALS advocacy groups but this legislation is targeted at terminal and critical conditions and those that are severely debilitating. This feels encouraging to me - we all know how severely tinnitus and hyperacusis can impact quality of life at their worst and even hearing-loss in itself is a risk factor for cognitive decline and dementia.

https://www.braun.senate.gov/senato...way-act-patients-serious-and-life-threatening

Really exciting. This is what we need to see more of.

 

[Lucifer]

I think the outcomes of the two hearing assessments; The Hearing Handicap Inventory for Adults and Hearing Screening Inventory will give us an indication if hyperacusis symptoms improved. Many of the questions directly relate to the experiences/lifestyle changes people with hyperacusis experience.

Otherwise, they're doing the Loudness Discomfort Level... I'm not sure they'll want to test LDLs in patients with fresh new hair cells... or maybe they would?

I don't think they necessarily have to do a loudness discomfort test. The patient should know if they feel like their hyperacusis is improving then you know the treatment works. What we don't know is how many doses we need until the hyperacusis goes away and which type of hyperacusis does it treat. I hope it helps with pain hyperacusis.

They should only do a LDL test if a patient has basically no sensitivity at all and can go on and do their daily thing without having to worry about everyday sounds unless it's too loud.

Another way they could test for hyperacusis is asking the patient which everyday sounds they can handle and which everyday sounds they can't handle so the patient is not subjected to a LDL test which could make them worse.

 

[Emgee]

For ototoxic cases: does anyone know of any research pertaining to the vestibulo-cochlear nerve linking the inner ear to the brain? If FX-322 regenerates hair cells, how would the vestibulo-cochlear nerve be repaired?

 

[tommyd87]

Looking at the charts in eTrade, it looks someone (or some company) made a trade of 139.5k shares after hours, and there have been a number of big trades this week. In fact, it looks like this week represents the biggest week as far as trade volume is concerned. Anyone have any insight into what is going on? Maybe hedge funds are buying shares?

It is incredibly probable that firms from the outside are seeing some super beneficial promise in FX-322 and are actually increasingly confident it will work. It will be a safe investment if it does due to the fact it will be a premium pharmacy product and actually will work out to be a very clever investment. Australia company Cochlear was the same so shares set out at $3 and is now netting $190. Very very similar situations by the look of both.

 

[FGG]

For ototoxic cases: does anyone know of any research pertaining to the vestibulo-cochlear nerve linking the inner ear to the brain? If FX-322 regenerates hair cells, how would the vestibulo-cochlear nerve be repaired?

View attachment 39601

Often this is referring to synaptic nerve damage (aka hiding hearing loss). I'm not aware of any ototoxin that directly affects the nerve.

 

[Emgee]

Often this is referring to synaptic nerve damage (aka hiding hearing loss). I'm not aware of any ototoxin that directly affects the nerve.

I hope both Frequency and Otonomy turn out to be successful because I don't know what kind of damage I have.

 

[Lucifer]

I hope both Frequency and Otonomy turn out to be successful because I don't know what kind of damage I have.

I just hope we all get the most benefit with FX-322. We will be waiting a lot longer for OTO-413 to come out unless we can get compassionate use.

Since we know how many IHCs and OHCs we have, do we know how much synapses a person has?

 

[FGG]

I hope both Frequency and Otonomy turn out to be successful because I don't know what kind of damage I have.

This has been said a million times but, at some point, diagnostics will have to catch up to treatments.

 

[jordan chis]

Is there any way to convince Frequency Therapeutics to test for hyperacusis in their next trial? I know tinnitus is on the rating list to see how it's affected. I would like to know more about hyperacusis too. As many/many of us have both.

Can we write them or petition? Just thinking out loud.

Do you think it's possible that a few of the 96 participants have hyperacusis? Or even just one person? I really do hope that this can treat hyperacusis.