Frequency Therapeutics — Hearing Loss Regeneration
- Thread starter RB2014
- Start date
MemberI even screenshoted that post because it has to be the most stupidest comment I have ever seen in these forums. More stupid than Michael Leigh's comments about TRT lol.
I can't believe someone pulled the "white privileged" on this forum. I don't know if it's hilarious or sad.
And you should know that Hazel is an oppressed woman. You could at least give her 25% of your pay every month to support her woman rights.
Joke apart, thank you so much @Hazel, @Markku and all the team for your amazing commitment over the years.
Even though I don't come often on this forum myself (anymore), I know that it has helped and continue helping so many members, and that it is a really valuable place to keep being up to date about what's going on.
Your dedication should be commended.
Regarding FX-322, we are far from end of phase 3, but we'll get there, and hopefully this will help tinnitus sufferer.
And you should know that Hazel is an oppressed woman. You could at least give her 25% of your pay every month to support her woman rights.
Joke apart, thank you so much @Hazel, @Markku and all the team for your amazing commitment over the years.
Even though I don't come often on this forum myself (anymore), I know that it has helped and continue helping so many members, and that it is a really valuable place to keep being up to date about what's going on.
Your dedication should be commended.
Regarding FX-322, we are far from end of phase 3, but we'll get there, and hopefully this will help tinnitus sufferer.
Yeah, that was a surprise.
I didn't expect a 2 dollar paywall to get content a week earlier would lead to such vitriol.
I didn't expect a 2 dollar paywall to get content a week earlier would lead to such vitriol.
Koz
Member
- Dec 15, 2013
- 153
- Tinnitus Since
- 2009
- Cause of Tinnitus
- Unilateral sensorineural hearing loss
@Enclave you should try and have done the interview yourself then. Stop being a moron please. Everyone and everything needs something for their efforts regardless of everything else.
Anyway, I hope this treatment comes out sooner rather than later and that it works. I miss being normal with much lower levels of suffering so much! Starting to really hate having to "live and accept this".
Anyway, I hope this treatment comes out sooner rather than later and that it works. I miss being normal with much lower levels of suffering so much! Starting to really hate having to "live and accept this".
@Enclave, it gets released to everyone for free a short time later. She made a point of saying that from the onset. They aren't trying to gate keep tinnitus information and I think the anger is misdirected. You just have to wait a week or as @Hazel pointed out, message her for early access.
If you actually watched the whole video you would have seen that. @Hazel also specifically made a point of saying that if anyone couldn't afford it, message her.
I agree with @d'Wooluf, I lean left but that's a ridiculous assertion to the point where it almost comes off like you might be trolling.
She's not getting rich off this (it would be wrong to exploit sufferers but that's not what is going on here), just trying to cover the cost of equipment and studio time.
If you actually watched the whole video you would have seen that. @Hazel also specifically made a point of saying that if anyone couldn't afford it, message her.
I agree with @d'Wooluf, I lean left but that's a ridiculous assertion to the point where it almost comes off like you might be trolling.
She's not getting rich off this (it would be wrong to exploit sufferers but that's not what is going on here), just trying to cover the cost of equipment and studio time.
Back to Frequency: New insider buying (worth about a million):
http://insiderbuyingselling.com/?t=FREQ
Don't think it's very relevant (just like much of the selling) but usually only the selling gets anxiety posted here.
http://insiderbuyingselling.com/?t=FREQ
Don't think it's very relevant (just like much of the selling) but usually only the selling gets anxiety posted here.
- Feb 14, 2020
- 1,630
- Tinnitus Since
- 1-2019
- Cause of Tinnitus
- 20+ Years of Live Music, Motorcycles, and Power Tools
I believe executive stockholders are back in a lock-out period due to the private placement, so they won't be able to dispose of their vested options for a certain period of time. Take a look at the 8-K submission related to the private placement.
Also, Joel Marcus's purchase was part of the private placement. Since he is already a director at the firm and acquiring additional positions, a Form-4 submission was required. Some might argue that it is good news when venture capital investors return to invest money in a second round at firm. It is a sign that they believe the outlook is positive.
I'd like to add that despite a private placement of roughly 2.3M shares at $18. Common stock did not really drop this week despite the dilution. Lots of private investors holding on to their shares.
- Aug 5, 2019
- 1,852
- Tinnitus Since
- 05/2019
- Cause of Tinnitus
- Autoimmune hyperacusis from Sjogren's Syndrome
I'm sorry if this comes off sycophantic, but Tinnitus Talk is possibly the best medical forum I've come across. And it's essentially carried by a handful of stars.
I'm going to assume that @Enclave's post was trolling. It's unthinkable that someone would think that was an example of white privilege.
I'm going to assume that @Enclave's post was trolling. It's unthinkable that someone would think that was an example of white privilege.
- Apr 15, 2017
- 1,419
- Tinnitus Since
- 2008
- Cause of Tinnitus
- Noise
@Diesel
I have been buying and selling FREQ stock the last 2 months. I'm planning to eventually hold it for the long term though but I'm quite limited on money. Anyway, I've made over a thousand pounds so far, I buy under $20 or thereabouts and sell around $23 to $24. I reinvest all the initial cash so I can hold more stocks in the company.
I do plan to hold them before the results of the trial though. I guess then it'll shoot up or down depending how it goes?
Obviously my main hope this works goes beyond financial profit, thanks for the info on the insider trading - you beat me to it to update the forum.
Anyway, lots of momentum on the forums for traders on this stock.
I have been buying and selling FREQ stock the last 2 months. I'm planning to eventually hold it for the long term though but I'm quite limited on money. Anyway, I've made over a thousand pounds so far, I buy under $20 or thereabouts and sell around $23 to $24. I reinvest all the initial cash so I can hold more stocks in the company.
I do plan to hold them before the results of the trial though. I guess then it'll shoot up or down depending how it goes?
Obviously my main hope this works goes beyond financial profit, thanks for the info on the insider trading - you beat me to it to update the forum.
Anyway, lots of momentum on the forums for traders on this stock.
- Feb 14, 2020
- 1,630
- Tinnitus Since
- 1-2019
- Cause of Tinnitus
- 20+ Years of Live Music, Motorcycles, and Power Tools
Yeah mid/small cap volatility has probably been your friend this first half of 2020. FREQ is not immune from radical swings in this space.
If the firm continues to be active (press releases, investment activity) leading up to the end of the Phase 2A, volume trades should drive the stock up. This run-up in price will happen prior to the announcement of the Phase 2A readout, as FOMO sets in, and investors get anxious.
The first readout could have a few outcomes. If investor speculation is met/exceeded, it will probably skyrocket in the short term. However, if there's a lot of FOMO hype, and positive results don't meet investor speculation (primary outcomes don't improve much beyond Phase 1/2 readout), it may stay flat or even decrease from the pre-announcement highs. Obviously if the Phase 2A doesn't have acceptable outcomes, it will tank in the short term.
The other thing investors will be looking for the is the Breakthrough Therapy status. This may end up causing a greater buying spree than the Phase 2A results. So, even if you buy/hold through the Phase 2A, BT status may provide additional gains.
UHPTS
Member
- Jan 28, 2020
- 196
- Tinnitus Since
- 10/2019
- Cause of Tinnitus
- Taking drugs on penile fracture
I also bought FREQ stocks and plan to buy more and keep them. My idea is that I support them for the good cause. If they succeed many people will benefit and I can use the money for my own treatment. If they don't I still get to feel good for supporting their honorable quest. There is actually nothing to lose when buying their or other new pharma stock.
To be fair to @Enclave, his point about minority groups typically having less disposable income than whites and therefore being disadvantaged by paid content would be somewhat valid if the content was only available at a cost indefinitely. However, as it is available for free next week, the point is moot. Maybe @Enclave missed that part in the video.
Also, it's a private site run by volunteers. There is no obligation to provide any content for free and in fact it would presumably be unsustainable to do so. Therefore, donations are essential in order that @Enclave and myself can enjoy content for free.
Final point: I notice the deliberate use of the word 'person', rather than 'woman'. As has already been pointed out, women typically earn significantly less than men, therefore the accusation that a woman is financially privileged needs to be very specifically targeted, otherwise it would be safer to assume that the opposite is true.
Oto
Member
- May 17, 2020
- 11
- Tinnitus Since
- 4/4/2020
- Cause of Tinnitus
- Unknown / High frequencies pre-presbycusis?
I have just read that paper.
@FGG, I'd like to thank you for all information you bring to this community.
Just 4 out of 15 patients with 10 dB Improvement at 8000 Hz among those who received FX-322 is something (considering that there is nothing so far), but it is not an impressive result (considering this is an optimistic headline from the company).
Maybe, I'm pessimistic by nature.
- Feb 14, 2020
- 1,630
- Tinnitus Since
- 1-2019
- Cause of Tinnitus
- 20+ Years of Live Music, Motorcycles, and Power Tools
It would have been helpful to show whether the 4/15 were part of the Mild or Moderate-Severe hearing loss patient group. Considering the ceiling effect encountered with the mild hearing loss patients... I suspect the 4 that saw the 10 dB improvement are the same 4 that they've continued to focus on throughout their presentation. So really, it's probably 4/6 with Moderate-Severe hearing loss saw a 10 dB improvement.
Doubling word scores, however, is a monumental achievement. They are measuring up to 16000 Hz in this trial and I would be extremely surprised if they didn't get dramatic UHF audiogram results considering how unheard of the word score results are.
I know not everyone has listened to the Tinnitus Talk Podcast yet but he talks about multiple dosing as in the phase 2A trial as having a possible additive effect increasing penetrance and they want to monitor what that range is.
I think it could be the opposite, the less severely effected probably didn't "use up" the drug in terms of binding substrate further towards the base of the cochlea. But agree, that would be really useful information! Though that should become apparent with phase 2A results.
Also of importance is that of the 15 people who were treated, 8 got a low dose of FX-322, and 7 got a high dose (which is the regular dose for the Phase 2a trials). I've never seen it explicitly stated by Frequency, but many on this forum speculate that the 4 responders were in the group of 7 that got the high dose. Other important bits:
* Everyone saw word score improvements, it's just that only 4 met the threshold for statistically significant.
* People were continuing to improve, even at day 90 when the study ended (see slides 21 and 22).
Since the current study is measuring out to 210 days, it's possible we could see everyone who gets a single dose show statistical improvements.
For the word scores, yes. The question was weather the ones who improved audiometrically at 8k were the same 4.
- Sep 21, 2016
- 1,051
- Tinnitus Since
- 2011 - T, 2016- H, relapsed 2019
- Cause of Tinnitus
- noise-induced
Something that intrigues me is what the timeframe is for this drug to take effect and how long patients could expect to see improvements for.
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